DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment B52 and srsf6a

DIOPT Version :9

Sequence 1:	NP_001014619.2	Gene:	B52 / 41670	FlyBaseID:	FBgn0004587	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	XP_005161979.1	Gene:	srsf6a / 406775	ZFINID:	ZDB-GENE-040426-2824	Length:	400	Species:	Danio rerio

Alignment Length:	386	Identity:	214/386 - (55%)
Similarity:	262/386 - (67%)	Gaps:	46/386 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RVYVGGLPYGVRERDLERFFKGYGRTRDILIKNGYGFVEFEDYRDADDAVYELNGKELLGERVVV 69
            |||:|.|.|.|||:|::|||.|||:..::.:|||||||||||.|||||||||||||||.||||:|
Zfish     3 RVYIGRLSYHVREKDIQRFFSGYGKLLEVDLKNGYGFVEFEDTRDADDAVYELNGKELCGERVMV 67

  Fly    70 EPARGTARGSNRDRY-------------DDRYGGRRGGGGG--------RYNEKNKNSRSSSRYG 113
            |.|||..|  :||.|             ...|||..|||||        .|:.:::..|  .:||
Zfish    68 EHARGPRR--DRDSYGGGGGGGGGGGGGGGYYGGGGGGGGGGGGGGGRSGYSSRSRTGR--DKYG 128

  Fly   114 PPLRTEYRLIVENLSSRVSWQDLKDYMRQAGEVTYADAHKQRRNEGVVEFASLSDMKTAIEKLDD 178
            ||:||||||||||||||.|||||||:||||||||||||||:|.||||:||.|.|||:.|:||||.
Zfish   129 PPVRTEYRLIVENLSSRCSWQDLKDFMRQAGEVTYADAHKERANEGVIEFRSYSDMRRALEKLDG 193

  Fly   179 TELNGRRIHLVEDRRGGRSGGGGGSGRGRSRSSSSRSRSRSRRRSRSRRSSHSRSKSRS---RSK 240
            |::|||:|.||||:...|....|...|.|||   .||||||||.||||.:|.|||:|||   ||:
Zfish   194 TDINGRKIRLVEDKPRRRRSYSGSRSRSRSR---RRSRSRSRRSSRSRSNSRSRSRSRSRRHRSR 255

  Fly   241 SRGG-RSKSKSPVKSRSR---SRSRSNKSRDVSKSKSKSH-SRTRSRSPK---RERDSRSRSRSV 297
            ||.| ||:|||..||||:   |:|||...:..|:|:|::| ||:||.|.|   |..|.:|||:|.
Zfish   256 SRSGRRSRSKSGHKSRSKSPSSKSRSRNRKSHSRSRSRTHKSRSRSTSRKSRSRSDDRKSRSKST 320

  Fly   298 SK-RESRSRSRSKSIHRDSRSRDRSASAEN--KSRSRSRSRSASPKNGNA---SPDRNNES 352
            || :..|.||:.||:.:.||||..| ..||  ..|.:|.|||.||:...:   ||||::.|
Zfish   321 SKVKSDRGRSKEKSVSKKSRSRSAS-PMENGDGERPKSASRSPSPQAEQSKYKSPDRHSRS 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
B52	NP_001014619.2	RRM1_SRSF4_like	5..74	CDD:240783	49/68 (72%)
B52	NP_001014619.2	RRM2_SRSF4_like	120..191	CDD:241044	55/70 (79%)
srsf6a	XP_005161979.1	RRM	<3..137	CDD:223796	73/137 (53%)
		RRM_SF	3..72	CDD:302621	49/68 (72%)
		RRM2_SRSF4_like	135..206	CDD:241044	55/70 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	109	1.000	Domainoid score	I6288
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	359	1.000	Inparanoid score	I2173
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1315388at2759
OrthoFinder	1	1.000	-	-		FOG0000217
OrthoInspector	1	1.000	-	-		otm26204
orthoMCL	1	0.900	-	-		OOG6_101955
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X517
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.830