DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment B52 and Srsf4

DIOPT Version :9

Sequence 1:	NP_001014619.2	Gene:	B52 / 41670	FlyBaseID:	FBgn0004587	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_001102155.1	Gene:	Srsf4 / 362612	RGDID:	1561347	Length:	488	Species:	Rattus norvegicus

Alignment Length:	401	Identity:	214/401 - (53%)
Similarity:	253/401 - (63%)	Gaps:	75/401 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RVYVGGLPYGVRERDLERFFKGYGRTRDILIKNGYGFVEFEDYRDADDAVYELNGKELLGERVVV 69
            |||:|.|.|..||||:||||||||:..::.:|||||||||:|.|||||||||||||:|.||||:|
  Rat     3 RVYIGRLSYQARERDVERFFKGYGKILEVDLKNGYGFVEFDDLRDADDAVYELNGKDLCGERVIV 67

  Fly    70 EPARGTARGSNRDRYDDRYGGRRGGGGGRYNEKNKNSRSSSRYGPPLRTEYRLIVENLSSRVSWQ 134
            |.|||..|       |..||..|.|.|.|.:.::|       ||||.||||||||||||||.|||
  Rat    68 EHARGPRR-------DGSYGSGRSGYGYRRSGRDK-------YGPPTRTEYRLIVENLSSRCSWQ 118

  Fly   135 DLKDYMRQAGEVTYADAHKQRRNEGVVEFASLSDMKTAIEKLDDTELNGRRIHLVEDRRGGRSGG 199
            |||||||||||||||||||.|:||||:||.|.||||.|:||||.||:|||:|.||||:.|.|...
  Rat   119 DLKDYMRQAGEVTYADAHKGRKNEGVIEFVSYSDMKRALEKLDGTEVNGRKIRLVEDKPGSRRRR 183

  Fly   200 GGGSGRGRSRSSS-------SRSR------SRSRRRSRSRRSSHSRSKSRSR--SKSRGGRSKSK 249
            .....|..|||.|       ||||      |.|:.|||||..||||||||||  |:||..:.||:
  Rat   184 SYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSHSRSKSRSRSQSRSRSKKEKSR 248

  Fly   250 SPVK-SRSRSRSRSNKSRDVSKSKSKSHS-----------RTRSRSPKRERDSRSRSRSVSKR-- 300
            ||.| ::||||||   |.|.|:||||.|:           :.:|.||.| .||:|||||..:|
  Rat   249 SPSKDNKSRSRSR---SPDKSRSKSKDHAEDKLQNNDSAGKAKSHSPSR-HDSKSRSRSQERRAE 309

  Fly   301 ------------------ESRSRSRSKSIHRDSRSRDRSASAE-------NKSRSRSRSRSASPK 340
                              :||||||||.   .||||.||.|.:       ::..|||||||.|.:
  Rat   310 EERRSSTSRGHSQEKSLLKSRSRSRSKV---GSRSRSRSKSKDKRKGRKRSREESRSRSRSKSER 371

  Fly   341 NGNASPDRNNE 351
            :...|..|:::
  Rat   372 SRKHSSKRDSK 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
B52	NP_001014619.2	RRM1_SRSF4_like	5..74	CDD:240783	49/68 (72%)
B52	NP_001014619.2	RRM2_SRSF4_like	120..191	CDD:241044	58/70 (83%)
Srsf4	NP_001102155.1	RRM1_SRSF4_like	3..72	CDD:240783	49/68 (72%)
Srsf4	NP_001102155.1	RRM2_SRSF4_like	104..175	CDD:241044	58/70 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353224
Domainoid	1	1.000	113	1.000	Domainoid score	I5979
eggNOG	1	0.900	-	-		E1_COG0724
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	350	1.000	Inparanoid score	I2210
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1315388at2759
OrthoFinder	1	1.000	-	-		FOG0000217
OrthoInspector	1	1.000	-	-		otm46259
orthoMCL	1	0.900	-	-		OOG6_101955
Panther	1	1.100	-	-	O	PTHR23147
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X517
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.800