DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment B52 and srsf4

DIOPT Version :9

Sequence 1:	NP_001014619.2	Gene:	B52 / 41670	FlyBaseID:	FBgn0004587	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_955868.1	Gene:	srsf4 / 321872	ZFINID:	ZDB-GENE-030131-591	Length:	366	Species:	Danio rerio

Alignment Length:	403	Identity:	205/403 - (50%)
Similarity:	241/403 - (59%)	Gaps:	108/403 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SRVYVGGLPYGVRERDLERFFKGYGRTRDILIKNGYGFVEFEDYRDADDAVYELNGKELLGERVV 68
            ||||||.|.|..||:|:||||||||:..::.:|||||||||:|.||||||||:||||:|.|:||:
Zfish     2 SRVYVGKLSYRAREKDVERFFKGYGKILEVDLKNGYGFVEFDDPRDADDAVYDLNGKDLCGKRVI 66

  Fly    69 VEPARGTAR-GSNRDRYDDRYGGRRGGGGGRYNEKNKNSRSSSRYGPPLRTEYRLIVENLSSRVS 132
            ||...|..| |.||....:|||  ||||||          ...|||||.||:|||||||||||.|
Zfish    67 VEHTIGQRRDGGNRSGRSNRYG--RGGGGG----------GGDRYGPPTRTDYRLIVENLSSRCS 119

  Fly   133 WQDLKDYMRQAGEVTYADAHKQRRNEGVVEFASLSDMKTAIEKLDDTELNGRRIHLVEDRRGGRS 197
            ||||||||||||||||||.:|.|:||||:||...||||.|:||||.||:|||:|.|:|||.|.|
Zfish   120 WQDLKDYMRQAGEVTYADTNKGRKNEGVIEFRQYSDMKRALEKLDGTEVNGRKIRLIEDRPGAR- 183

  Fly   198 GGGGGSGRGRSRS-SSSRSRSRSRRRSRSRRSSHSR---------SKSRSRS-----KSRGGR-- 245
                   |.||.| |:|||||||||..|||  ||||         |:|||||     |||..|
Zfish   184 -------RRRSYSRSASRSRSRSRRSRRSR--SHSRTSSRSGASGSRSRSRSTSKKAKSRSSRME 239

  Fly   246 ----------------SKSKSPVK-------------SRSRSRSRSNKSRDVSKS---------- 271
                            |.|:||..             |||||||:|...||:|:.
Zfish   240 ESSNGARKGGDSGRDNSLSRSPQNKKSKRENKRGRSDSRSRSRSKSRNDRDLSRESGSKSQEASK 304

  Fly   272 ----------KSKSHSRTRSRSP---KRERDSRSRSRSVSKRESRSRSRSKSIHRDSRSRDRSAS 323
                      :|::|||:||::|   .:.|:|||||||.||..|.|||:|.|
Zfish   305 SGDEGRAGTHRSRAHSRSRSQTPPNADQRRESRSRSRSRSKSRSHSRSQSYS------------- 356

  Fly   324 AENKSRSRSRSRS 336
               :|||||||||
Zfish   357 ---RSRSRSRSRS 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
B52	NP_001014619.2	RRM1_SRSF4_like	5..74	CDD:240783	46/68 (68%)
B52	NP_001014619.2	RRM2_SRSF4_like	120..191	CDD:241044	54/70 (77%)
srsf4	NP_955868.1	RRM1_SRSF4_like	3..72	CDD:240783	46/68 (68%)
srsf4	NP_955868.1	RRM2_SRSF4_like	107..178	CDD:241044	54/70 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595312
Domainoid	1	1.000	109	1.000	Domainoid score	I6288
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	359	1.000	Inparanoid score	I2173
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1315388at2759
OrthoFinder	1	1.000	-	-		FOG0000217
OrthoInspector	1	1.000	-	-		otm26204
orthoMCL	1	0.900	-	-		OOG6_101955
Panther	1	1.100	-	-	O	PTHR23147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X517
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.900