DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment B52 and tiar-2

DIOPT Version :9

Sequence 1:	NP_001014619.2	Gene:	B52 / 41670	FlyBaseID:	FBgn0004587	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_496718.1	Gene:	tiar-2 / 174909	WormBaseID:	WBGene00012904	Length:	434	Species:	Caenorhabditis elegans

Alignment Length:	256	Identity:	62/256 - (24%)
Similarity:	101/256 - (39%)	Gaps:	60/256 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VYVGGLPYGVRERDLERFFKGYGRTRDILI--------KNGYGFVEFEDYRDADDAVYELNGKEL 62
            |:||.|...:....|...|..:|...:..|        ..|||||.:....||:.|:.|:|| ..
Worm   134 VFVGDLCSEIDSTKLREAFVKFGEVSEAKIIRDNNTNKGKGYGFVSYPRREDAERAIDEMNG-AW 197

  Fly    63 LGERVV------VEPARGTARGSNRDRYDDRYGGRRGGGGG---RYNEKNKNSRSSSRYGPPLRT 118
            ||.|.:      .:|.....||.:|       |.|||||||   ||:.:::.:.... :......
Worm   198 LGRRTIRTNWATRKPDEDGERGGDR-------GDRRGGGGGGRDRYHNQSEKTYDEI-FNQAAAD 254

  Fly   119 EYRLIVENLSSRVSWQDLKDYMRQA----GEVTYADAHKQRRNEGVVEFASLSDMKTAIEKLDDT 179
            ...:.|.|:::..     :|.:|:|    |.:......| .:....|:|.:......||.::::.
Worm   255 NTSVYVGNIANLG-----EDEIRRAFDRFGPINEVRTFK-IQGYAFVKFETKESAARAIVQMNNA 313

  Fly   180 ELNGRRIHLVEDRRG-----------------------GRSGGGGGS-GRGRSRSSSSRSR 216
            ::.|:.:.....:.|                       |.||||||| |.|.|:.|:...|
Worm   314 DIGGQIVRCSWGKSGDSGKPSERGSGGGGGSGNYGYGYGNSGGGGGSGGPGNSQFSNFNQR 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
B52	NP_001014619.2	RRM1_SRSF4_like	5..74	CDD:240783	23/81 (28%)
B52	NP_001014619.2	RRM2_SRSF4_like	120..191	CDD:241044	12/74 (16%)
tiar-2	NP_496718.1	RRM	36..321	CDD:223796	48/201 (24%)
		RRM_SF	42..113	CDD:302621
		RRM_SF	133..207	CDD:302621	22/73 (30%)
		RRM3_TIA1_like	256..326	CDD:240800	12/75 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0724
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810