Protein Alignment B52 and Srsf1

DIOPT Version :10

• Sequence 1: NP_788671.2
• Gene: B52 / 41670
• FlyBaseID: FBgn0004587
• Length: 355
• Species: Drosophila melanogaster
• Sequence 2: NP_775550.2
• Gene: Srsf1 / 110809
• MGIID: 98283
• Length: 248
• Species: Mus musculus
• Alignment Length: 265
• Identity: 120/265 - (45%)
• Similarity: 147/265 - (55%)
• Gaps: 42/265 - (15%)

  Fly     5 RVYVGGLPYGVRERDLERFFKGYGRTRDILIKNGYG-----FVEFEDYRDADDAVYELNGKELLG 64
            |:|||.||..:|.:|:|..|..||..|||.:||..|     ||||||.|||:||||..:|.:..|
Mouse    17 RIYVGNLPPDIRTKDIEDVFYKYGAIRDIDLKNRRGGPPFAFVEFEDPRDAEDAVYGRDGYDYDG 81

  Fly    65 ERVVVEPARGTARGSNRDRYDDRYGGRRGGGGGRYNEKNKNSRSSSRYGPP-LRTEYRLIVENLS 128
            .|:.||..| :.||:.|       ||..|||||         ....||||| .|:|.|::|..|.
Mouse    82 YRLRVEFPR-SGRGTGR-------GGGGGGGGG---------APRGRYGPPSRRSENRVVVSGLP 129

  Fly   129 SRVSWQDLKDYMRQAGEVTYADAHKQRRNEGVVEFASLSDMKTAIEKLDDTEL---NGRRIHLVE 190
            ...|||||||:||:||:|.|||.:  |...|||||....||..|:.|||:|:.   .|...::..
Mouse   130 PSGSWQDLKDHMREAGDVCYADVY--RDGTGVVEFVRKEDMTYAVRKLDNTKFRSHEGETAYIRV 192

  Fly   191 DRRGGRSGGGGGSGRGRSRSSSSRSRSRSRRRSRSRRSSHSRSKSRSRSKSRGGRSKSKSPVKSR 255
            ...|.||            .|..|||||||.|||||..|:|||:|.|..:|||  |...||..||
Mouse   193 KVDGPRS------------PSYGRSRSRSRSRSRSRSRSNSRSRSYSPRRSRG--SPRYSPRHSR 243

  Fly   256 SRSRS 260
            ||||:
Mouse   244 SRSRT 248

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
B52	NP_788671.2	RRM1_SRSF4_like	5..74	CDD:409774	36/73 (49%)
		RRM2_SRSF4_like	120..191	CDD:410012	32/73 (44%)
Srsf1	NP_775550.2	RRM1_SRSF1	12..90	CDD:410010	36/72 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	88..134		21/62 (34%)
		RRM2_SRSF1	113..196	CDD:410160	37/84 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	191..248		33/70 (47%)
		Interaction with SAFB1. /evidence=ECO:0000250	198..247		31/62 (50%)