DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment B52 and Cstf2

DIOPT Version :9

Sequence 1:	NP_001014619.2	Gene:	B52 / 41670	FlyBaseID:	FBgn0004587	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_001345982.1	Gene:	Cstf2 / 108062	MGIID:	1343054	Length:	603	Species:	Mus musculus

Alignment Length:	185	Identity:	44/185 - (23%)
Similarity:	64/185 - (34%)	Gaps:	72/185 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VYVGGLPYGVRERDLERFFKGYGRT--------RDILIKNGYGFVEFEDYRDADDAVYELNGKEL 62
            |:||.:||...|..|:..|...|..        |:.....||||.|::|...|..|:..|||:|.
Mouse    18 VFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGREF 82

  Fly    63 LGERVVVEPARGTARGSNRDRYDDRYGGRRGGGGGRYNEKNKNSRSS---------SRYG----- 113
            .|..:.|:.|.                          :||||....|         |.||
Mouse    83 SGRALRVDNAA--------------------------SEKNKEELKSLGTGAPVIESPYGESISP 121

  Fly   114 --------------PP-----LRTEYRLIVENLSSRVSWQDLKDYMRQAGEVTYA 149
                          ||     |..:.:|.|:|     |.|:.::.:.|..::.||
Mouse   122 EDAPESISKAVASLPPEQMFELMKQMKLCVQN-----SPQEARNMLLQNPQLAYA 171

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
B52	NP_001014619.2	RRM1_SRSF4_like	5..74	CDD:240783	25/75 (33%)
B52	NP_001014619.2	RRM2_SRSF4_like	120..191	CDD:241044	8/30 (27%)
Cstf2	NP_001345982.1	RRM	<7..332	CDD:330708	44/185 (24%)
		RRM_CSTF2_CSTF2T	18..92	CDD:241115	24/73 (33%)
		CSTF2_hinge	113..191	CDD:316816	14/64 (22%)
		Rnc	<418..>475	CDD:330804
		CSTF_C	559..599	CDD:316795
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0724
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900