DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rbp4 and PUB1

DIOPT Version :9

Sequence 1:	NP_476935.1	Gene:	Rbp4 / 41668	FlyBaseID:	FBgn0010258	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_014382.1	Gene:	PUB1 / 855716	SGDID:	S000004961	Length:	453	Species:	Saccharomyces cerevisiae

Alignment Length:	305	Identity:	65/305 - (21%)
Similarity:	116/305 - (38%)	Gaps:	62/305 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 RKIFIGGLSTQTTVETLRGFFSQFGIVADAVVLRDPVSNHSRGFGFVTYVDPKSVEI-VQRARPH 95
            |.:::|.|....|.:.|:.:|...|.:|:..::.|. :|.:..:.||.|.......| :|.....
Yeast    75 RVLYVGNLDKAITEDILKQYFQVGGPIANIKIMIDK-NNKNVNYAFVEYHQSHDANIALQTLNGK 138

  Fly    96 TIDNKIVETKHALPRQDFKRGGGVGSVVGSFGCEAGFMNSKRIFLGGLKEYHDENIVREYFSQFG 160
            .|:|.||:...|...|                 ::...::..:|:|.|....|:..:|..|..|.
Yeast   139 QIENNIVKINWAFQSQ-----------------QSSSDDTFNLFVGDLNVNVDDETLRNAFKDFP 186

  Fly   161 PVASVKLLMDRETGRQRAFGFLEFVDPSSAEKALAP-----------RKHWILQTLVEVKRSTQK 214
            ...|..::.|.:||..|.:||:.|.....|:.|:..           |.:|      ..||....
Yeast   187 SYLSGHVMWDMQTGSSRGYGFVSFTSQDDAQNAMDSMQGQDLNGRPLRINW------AAKRDNNN 245

  Fly   215 ADR-RFRFPIFSSVRAGYIPPQPATADSYNYNNPNYNPYLAQSV-----------LPPSAFTNGW 267
            .:. :.|....::.|.|:        ..||.|| |.|..:..::           :|||:.  |.
Yeast   246 NNNYQQRRNYGNNNRGGF--------RQYNSNN-NNNMNMGMNMNMNMNMNNSRGMPPSSM--GM 299

  Fly   268 AHYVIPMAPKPTPGQNMAASLPSQ---QLAEHSLNGHGPDMWSSY 309
            ....:|:..:..|.|:....||.|   |..:|.:....|.:.::|
Yeast   300 PIGAMPLPSQGQPQQSQTIGLPPQVNPQAVDHIIRSAPPRVTTAY 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbp4	NP_476935.1	RRM_SF	33..110	CDD:302621	19/77 (25%)
Rbp4	NP_476935.1	RRM2_hnRNPA_like	137..209	CDD:240774	19/82 (23%)
PUB1	NP_014382.1	RRM1_PUB1	77..150	CDD:410026	18/73 (25%)
		RRM2_PUB1	161..240	CDD:410031	19/84 (23%)
		RRM3_PUB1	341..414	CDD:410033	1/4 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910