DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rbp4 and DAZ4

DIOPT Version :9

Sequence 1:	NP_476935.1	Gene:	Rbp4 / 41668	FlyBaseID:	FBgn0010258	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_001375413.1	Gene:	DAZ4 / 57135	HGNCID:	15966	Length:	723	Species:	Homo sapiens

Alignment Length:	355	Identity:	65/355 - (18%)
Similarity:	127/355 - (35%)	Gaps:	107/355 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 IFIGGLSTQTTVETLRGFFSQFGIVADAVVLRDPVSNHSRGFGFVTYVDPKSVEIVQRARPHTID 98
            :|:||:..:.....:...|.::|.|.:..::.:. :..|:|:|||::|:...|:.:..::.|...
Human    42 VFVGGIDARMDETEIGSCFGRYGSVKEVKIITNR-TGVSKGYGFVSFVNDVDVQKIVGSQIHFHG 105

  Fly    99 NKI----------VETKHALPR-----------------------------------QDFKRGGG 118
            .|:          :..:|..||                                   |..:....
Human   106 KKLKLGPAIRKQKLCARHVQPRPLVVNPPPPPQFQNVWRNPNTETYLQPQITPNPVTQHVQSAAN 170

  Fly   119 VGSVVGSFGCEAGFMNS-----------------KRIFLGGLKEYHDENIVREYFSQFGPVASVK 166
            ..:...:...||...:|                 ..:|:||:....||..:...|.::|.|..||
Human   171 PETPNSTISREASTQSSSAAASQGWVLPEGKIVPNTVFVGGIDARMDETEIGSCFGRYGSVKEVK 235

  Fly   167 LLMDRETGRQRAFGFLEFVDPSSAEKALAPRKHWILQTLVEVKRSTQKADRRFRFPIFSSVRAGY 231
            ::.:| ||..:.:||:.||:....:|.:..:.|:..:     |.....|.|:      ..:.|.:
Human   236 IITNR-TGVSKGYGFVSFVNDVDVQKIVGSQIHFHGK-----KLKLGPAIRK------QKLCARH 288

  Fly   232 IPPQPATADSYNYNNPNYNPYLAQSVLPPSAFTNGWAH-----YVIP-MAPKPTPGQNMAASLPS 290
            :.|:|...      ||.          ||..|.|.|.:     |:.| :.|.|.          :
Human   289 VQPRPLVV------NPP----------PPPQFQNVWRNPNTETYLQPQITPNPV----------T 327

  Fly   291 QQLAEHSLNGHGPDMWSSYPKTGIYSAQEW 320
            |.:..:|...|.|....:..:..:|:.||:
Human   328 QHVQAYSAYPHSPGQVITGCQLLVYNYQEY 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbp4	NP_476935.1	RRM_SF	33..110	CDD:302621	16/85 (19%)
Rbp4	NP_476935.1	RRM2_hnRNPA_like	137..209	CDD:240774	19/71 (27%)
DAZ4	NP_001375413.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		RRM_DAZL	35..116	CDD:410073	15/74 (20%)
		PABP-1234	42..412	CDD:130689	65/355 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..192		4/28 (14%)
		RRM_DAZL	200..281	CDD:410073	21/86 (24%)
		Daz	407..427	CDD:408642
		Daz	431..451	CDD:408642
		Daz	455..475	CDD:408642
		Daz	479..499	CDD:408642
		Daz	503..523	CDD:408642
		Daz	527..547	CDD:408642
		Daz	551..571	CDD:408642
		Daz	575..595	CDD:408642
		Daz	599..619	CDD:408642
		Daz	623..643	CDD:408642
		Daz	647..667	CDD:408642
		Daz	671..691	CDD:408642
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910