DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rbp4 and Hnrnpa2b1

DIOPT Version :9

Sequence 1:	NP_476935.1	Gene:	Rbp4 / 41668	FlyBaseID:	FBgn0010258	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_001361674.1	Gene:	Hnrnpa2b1 / 53379	MGIID:	104819	Length:	353	Species:	Mus musculus

Alignment Length:	409	Identity:	107/409 - (26%)
Similarity:	168/409 - (41%)	Gaps:	105/409 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 KEEGYEHLRKIFIGGLSTQTTVETLRGFFSQFGIVADAVVLRDPVSNHSRGFGFVTYVDPKSVEI 88
            |:...|..||:||||||.:||.|:||.::.|:|.:.|.||:|||.|..||||||||:.....|:.
Mouse    13 KKREKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDA 77

  Fly    89 VQRARPHTIDNKIVETKHALPRQDFKRGGGVGSVVGSFGCEAGFMNSKRIFLGGLKEYHDENIVR 153
            ...||||:||.::||.|.|:.|::..:.|...:|             |::|:||:||..:|:.:|
Mouse    78 AMAARPHSIDGRVVEPKRAVAREESGKPGAHVTV-------------KKLFVGGIKEDTEEHHLR 129

  Fly   154 EYFSQFGPVASVKLLMDRETGRQRAFGFLEFVDPSSAEKALAPRKHWI------------LQTLV 206
            :||.::|.:.:::::.||::|::|.|||:.|.|....:|.:..:.|.|            .|.:.
Mouse   130 DYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGHNAEVRKALSRQEMQ 194

  Fly   207 EVKRSTQKADRRFRFPIFSSVRAGYIPPQPAT-----ADSYNYNNPNYNPYLAQSVLPPSAFTNG 266
            ||:.|.......|.|. .|....|...|.|.:     :|.|....               .|.:|
Mouse   195 EVQSSRSGRGGNFGFG-DSRGGGGNFGPGPGSNFRGGSDGYGSGR---------------GFGDG 243

  Fly   267 WAHYVIPMAPKPTPGQNMAASLPSQQLAEHSLNGHGPDMWS--------------------SYPK 311
            :..|      ...||.......|..........|.||...:                    ||..
Mouse   244 YNGY------GGGPGGGNFGGSPGYGGGRGGYGGGGPGYGNQGGGYGGGYDNYGGGNYGSGSYND 302

  Fly   312 TGIYSAQEWTSSKVAEWGPKAGHKHAQTSTNDRAKIDLKELQAATFNNKLDFGARGDADRMSGAG 376
            .|.|:.|.      :.:||                     :::..|.     |:|.......|..
Mouse   303 FGNYNQQP------SNYGP---------------------MKSGNFG-----GSRNMGGPYGGGN 335

  Fly   377 LGLGLTGGAAVGVGAIKKW 395
            .|.|.:||:. |.|...::
Mouse   336 YGPGGSGGSG-GYGGRSRY 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbp4	NP_476935.1	RRM_SF	33..110	CDD:302621	40/76 (53%)
Rbp4	NP_476935.1	RRM2_hnRNPA_like	137..209	CDD:240774	24/83 (29%)
Hnrnpa2b1	NP_001361674.1	Nuclear localization signal. /evidence=ECO:0000255	9..15		1/1 (100%)
		RRM1_hnRNPA2B1	19..99	CDD:410155	41/79 (52%)
		RRM2_hnRNPA2B1	112..191	CDD:409995	23/78 (29%)
		Disordered. /evidence=ECO:0000250\|UniProtKB:P22626	193..353		37/214 (17%)
		HnRNPA1	302..326	CDD:402981	7/55 (13%)
		Nuclear targeting sequence. /evidence=ECO:0000250	308..347		11/71 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BA81
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1202220at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820