Protein Alignment Rbp4 and MSI1

DIOPT Version :10

• Sequence 1: NP_476935.1
• Gene: Rbp4 / 41668
• FlyBaseID: FBgn0010258
• Length: 428
• Species: Drosophila melanogaster
• Sequence 2: NP_002433.1
• Gene: MSI1 / 4440
• HGNCID: 7330
• Length: 362
• Species: Homo sapiens
• Alignment Length: 356
• Identity: 105/356 - (29%)
• Similarity: 140/356 - (39%)
• Gaps: 80/356 - (22%)

  Fly    33 KIFIGGLSTQTTVETLRGFFSQFGIVADAVVLRDPVSNHSRGFGFVTYVDPKSVEIVQRARPHTI 97
            |:||||||.|||.|.||.:|.|||.|.:.:|:|||::..||||||||::|...|:.|.....|.:
Human    21 KMFIGGLSWQTTQEGLREYFGQFGEVKECLVMRDPLTKRSRGFGFVTFMDQAGVDKVLAQSRHEL 85

  Fly    98 DNKIVETKHALPRQDFKRGGGVGSVVGSFGCEAGFMNSKRIFLGGLKEYHDENIVREYFSQFGPV 162
            |:|.::.|.|.||:...:               ....:|:||:|||........|::||.|||.|
Human    86 DSKTIDPKVAFPRRAQPK---------------MVTRTKKIFVGGLSVNTTVEDVKQYFEQFGKV 135

  Fly   163 ASVKLLMDRETGRQRAFGFLEFVDPSSAEKALAPRKHWILQTLVEVKRS--------TQKADRRF 219
            ....|:.|:.|.|.|.|||:.|......||......|.|...:||.|::        |..|..|.
Human   136 DDAMLMFDKTTNRHRGFGFVTFESEDIVEKVCEIHFHEINNKMVECKKAQPKEVMSPTGSARGRS 200

  Fly   220 R-FP------IFSSVRAGYIPPQPAT---------ADSYNYNNPNY----NPYLAQSVLP----- 259
            | .|      :......||...|..|         |..|.|..|.:    .|..:..|||
Human   201 RVMPYGMDAFMLGIGMLGYPGFQATTYASRSYTGLAPGYTYQFPEFRVERTPLPSAPVLPELTAI 265

  Fly   260 -------------PSAFTNGWAHYVIPMAPKPTPGQNMAASLPSQQLAEHSLNGHGPDMWSSYPK 311
                         .:|...|...:...|||.|       .|.||:       .|......|..|.
Human   266 PLTAYGPMAAAAAAAAVVRGTGSHPWTMAPPP-------GSTPSR-------TGGFLGTTSPGPM 316

  Fly   312 TGIYSAQEWTSS-----KVAEWGPKAGHKHA 337
            ..:|.|....|.     ..|...|..|..|:
Human   317 AELYGAANQDSGVSSYISAASPAPSTGFGHS 347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rbp4	NP_476935.1	RRM_SF	34..105	CDD:473069	35/70 (50%)
		RRM2_hnRNPA_like	137..209	CDD:409766	27/71 (38%)
MSI1	NP_002433.1	RRM1_MSI	21..96	CDD:409990	37/74 (50%)
		PABP-1234	<32..339	CDD:130689	93/335 (28%)
		RRM2_MSI	110..183	CDD:240769	27/72 (38%)