DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rbp4 and tia1

DIOPT Version :9

Sequence 1:	NP_476935.1	Gene:	Rbp4 / 41668	FlyBaseID:	FBgn0010258	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	XP_012814227.2	Gene:	tia1 / 394890	XenbaseID:	XB-GENE-1002876	Length:	389	Species:	Xenopus tropicalis

Alignment Length:	320	Identity:	62/320 - (19%)
Similarity:	118/320 - (36%)	Gaps:	103/320 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 TAIKEEGYEHLRKIFIGGLSTQTTVETLRGFFSQFGIVADAVVLRDPVSNHSRGFGFVTYVDPKS 85
            :.::.:.:.|   :|:|.||.:.|.:.::..|:.||.::||.|::|..:..|:|:|||::.:...
Frog    98 STLRSQDHFH---VFVGDLSPEITTDDIKAAFAPFGRISDARVVKDMTTGKSKGYGFVSFFNKWD 159

  Fly    86 VE-IVQRARPHTIDNKIVET-----KHALPRQDFKRGGGVGSVVGSFGCEAGFMNSKR------- 137
            .| .:.:.....:..:.:.|     |...|:..::                  .|:|:
Frog   160 AENAIAQMGGQWLGGRQIRTNWATRKPPAPKSTYE------------------SNTKQLTYEEVV 206

  Fly   138 ---------IFLGGLKEYHDENIVREYFSQFGPVASVKLLMDRETGRQRAFGFLEFVDPSSAEKA 193
                     ::.||:.....|.::|:.||.||.:..|::..|      :.:.|:.|....||..|
Frog   207 NQSSPSNCTVYCGGVTSGLTEQLMRQTFSPFGQIMEVRVFPD------KGYSFVRFSSHESAAHA 265

  Fly   194 LAP-----------RKHW------ILQTLVEVKRSTQKADRRFRFPIFSSVRAGYIPPQPATADS 241
            :..           :.:|      :|..:.:|..::|     ..||          ||.......
Frog   266 IVSVNGTTIEGHVVKCYWGKETPDMLNPVQQVSEASQ-----ISFP----------PPYGQWGQW 315

  Fly   242 Y------------NYNNPNYNPY------LAQSVLPPSAFTNGWAHYVIPMAPKPTPGQN 283
            |            .:..|.|..|      ...|..|.||.|....:|.:    :|.||||
Frog   316 YGGAQQIGQYVPNGWQMPAYGVYGQAWSQQGYSQTPSSAATWVGPNYGV----QPQPGQN 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbp4	NP_476935.1	RRM_SF	33..110	CDD:302621	20/82 (24%)
Rbp4	NP_476935.1	RRM2_hnRNPA_like	137..209	CDD:240774	17/104 (16%)
tia1	XP_012814227.2	RRM1_TIA1	8..81	CDD:410027
		RRM2_TIA1	104..181	CDD:410030	20/79 (25%)
		RRM3_TIAR	214..286	CDD:241064	16/77 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910