DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rbp4 and hnrnpa1a

DIOPT Version :9

Sequence 1:	NP_476935.1	Gene:	Rbp4 / 41668	FlyBaseID:	FBgn0010258	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	XP_021335234.1	Gene:	hnrnpa1a / 393467	ZFINID:	ZDB-GENE-040426-1546	Length:	445	Species:	Danio rerio

Alignment Length:	229	Identity:	74/229 - (32%)
Similarity:	115/229 - (50%)	Gaps:	46/229 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 TAIKEEGY-----EHLRKIFIGGLSTQTTVETLRGFFSQFGIVADAV------------------ 62
            ||:.:|..     |.|||:||||||.:||.|:||..|.|:|.:.|.|
Zfish    22 TAMSKEQQTPREPEQLRKLFIGGLSFETTDESLRAHFEQWGTLTDCVVSPSAAIHMLMYEREEHL 86

  Fly    63 ----------VLRDPVSNHSRGFGFVTYVDPKSVEIVQRARPHTIDNKIVETKHALPRQDFKRGG 117
                      |:|||.:..|||||||||.....|:....||||.:|.:.||.|.|:.|:|..:.|
Zfish    87 KVAGFLYCSQVMRDPNTKRSRGFGFVTYSSVGEVDAAMDARPHKVDGRAVEPKRAVSREDSSKPG 151

  Fly   118 GVGSVVGSFGCEAGFMNSKRIFLGGLKEYHDENIVREYFSQFGPVASVKLLMDRETGRQRAFGFL 182
            ...:|             |::|:||:||..||..:||||.|||.:..|.::.::.:.::|.|.|:
Zfish   152 AHSTV-------------KKMFVGGIKEDTDEEHLREYFGQFGKIDEVNIMTEKNSDKRRGFAFI 203

  Fly   183 EFVDPSSAEKALAPRKHWILQTLVEVKRSTQKAD 216
            .|.|..:.::.:..:.|.:.....||:::..:.:
Zfish   204 TFDDHDAVDRIVIQKYHTVNGHNCEVRKALSREE 237

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbp4	NP_476935.1	RRM_SF	33..110	CDD:302621	40/104 (38%)
Rbp4	NP_476935.1	RRM2_hnRNPA_like	137..209	CDD:240774	22/71 (31%)
hnrnpa1a	XP_021335234.1	RRM_SF	36..144	CDD:327398	42/107 (39%)
		RRM_SF	157..233	CDD:327398	24/75 (32%)
		HnRNPA1	376..>392	CDD:314495
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1202220at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920