DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rbp4 and CG3335

DIOPT Version :9

Sequence 1:	NP_476935.1	Gene:	Rbp4 / 41668	FlyBaseID:	FBgn0010258	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_648337.1	Gene:	CG3335 / 39119	FlyBaseID:	FBgn0036018	Length:	918	Species:	Drosophila melanogaster

Alignment Length:	396	Identity:	87/396 - (21%)
Similarity:	139/396 - (35%)	Gaps:	109/396 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDAGNCASSACLGDCKGDGKTAIKEEGYEHLRKIFIGGLSTQTTVETLRGFFSQFGIVADAVVLR 65
            :||||       ...|....:..||:......:||...|:..||.|.||..|.|||.|.:..:..
  Fly   340 VDAGN-------AKWKHQQDSLSKEDDISESGRIFFRNLAYTTTEEDLRKLFEQFGPVVEVNLPL 397

  Fly    66 DPVSNHSRGFGFVTYVDPKSVEIVQRARPHTIDNKIVETK--HALPRQDFKRGGGVGSVVGSFGC 128
            |.::...:|||.|||:.|   |...:|. :|:|......:  |.||.:|.::..
  Fly   398 DKLTRKIKGFGTVTYMMP---EHALKAF-NTLDGTDFHGRLLHLLPSKDIEKNP----------- 447

  Fly   129 EAGFMNSKRIFLGGLKEYHDENIVREYFSQ--------------------FGPVASVKLLMDR-E 172
                           ||..|||.....|.:                    .|..|..::|..: :
  Fly   448 ---------------KEDLDENDASLSFKEKKALKLKKNAQKPIGWNTLFLGANAVAEILAKQFK 497

  Fly   173 TGRQRAFGFLEFVD-PSSAEKALAPRKHWILQTLVEVKRSTQKADRR---FRFPIFSSVRAGYIP 233
            |.::|   .|:..| .|||...||..:   .|.::|:||..::...|   |..|.........:.
  Fly   498 TSKER---ILDTSDGGSSAAVRLALGE---TQVVIEMKRFLEEEGVRLDAFDEPAKKRSNTVILA 556

  Fly   234 PQPATADSYNYNNPNYNPY--LAQSVLPPSAFTNGWAHYVIPMAPKPTPGQNMAASLPSQQLAEH 296
            .....|...:...|.::.:  :.:.|||||..| ....|..|          :.|....::||
  Fly   557 KNLPAATEISEITPIFSRFGPIGRIVLPPSGVT-ALIEYCDP----------LEARQAFKKLA-- 608

  Fly   297 SLNGHGPDMWSSYPKTGIYSAQEWTSSKV-------------AEWGPKAGHKHAQTSTNDRAKID 348
                     :|.:....:|  .||...:|             :|..||...|..:....:.||.|
  Fly   609 ---------YSKFKNAPLY--LEWAPEQVFTKTLSGEPVIPKSEPKPKEEVKPEEKPIVNDAKPD 662

  Fly   349 LKELQA 354
            .::.:|
  Fly   663 EEDSRA 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbp4	NP_476935.1	RRM_SF	33..110	CDD:302621	27/78 (35%)
Rbp4	NP_476935.1	RRM2_hnRNPA_like	137..209	CDD:240774	20/93 (22%)
CG3335	NP_648337.1	RRM1_RBM19	2..77	CDD:241008
		RRM_SF	250..314	CDD:302621
		RRM3_RBM19	362..440	CDD:241011	27/81 (33%)
		RRM4_RBM19	552..623	CDD:241013	17/94 (18%)
		RRM	<638..845	CDD:223796	8/31 (26%)
		RRM5_RBM19_like	679..760	CDD:240764
		RRM6_RBM19	785..864	CDD:241015
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464025
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930