DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rbp4 and HNRNPA2B1

DIOPT Version :9

Sequence 1:	NP_476935.1	Gene:	Rbp4 / 41668	FlyBaseID:	FBgn0010258	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_112533.1	Gene:	HNRNPA2B1 / 3181	HGNCID:	5033	Length:	353	Species:	Homo sapiens

Alignment Length:	397	Identity:	107/397 - (26%)
Similarity:	169/397 - (42%)	Gaps:	81/397 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 KEEGYEHLRKIFIGGLSTQTTVETLRGFFSQFGIVADAVVLRDPVSNHSRGFGFVTYVDPKSVEI 88
            |:...|..||:||||||.:||.|:||.::.|:|.:.|.||:|||.|..||||||||:.....|:.
Human    13 KKREKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDA 77

  Fly    89 VQRARPHTIDNKIVETKHALPRQDFKRGGGVGSVVGSFGCEAGFMNSKRIFLGGLKEYHDENIVR 153
            ...||||:||.::||.|.|:.|::..:.|...:|             |::|:||:||..:|:.:|
Human    78 AMAARPHSIDGRVVEPKRAVAREESGKPGAHVTV-------------KKLFVGGIKEDTEEHHLR 129

  Fly   154 EYFSQFGPVASVKLLMDRETGRQRAFGFLEFVDPSSAEKALAPRKHWI------------LQTLV 206
            :||.::|.:.:::::.||::|::|.|||:.|.|....:|.:..:.|.|            .|.:.
Human   130 DYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGHNAEVRKALSRQEMQ 194

  Fly   207 EVKRSTQKADRRFRFPIFSSVRAGYIPPQPAT-----ADSYNYNNPNYNPYLAQSVLPPSAFTNG 266
            ||:.|.......|.|. .|....|...|.|.:     :|.|....               .|.:|
Human   195 EVQSSRSGRGGNFGFG-DSRGGGGNFGPGPGSNFRGGSDGYGSGR---------------GFGDG 243

  Fly   267 WAHYVIPMAPKPTPGQNMAASLPSQQLAEHSLNGHGPDMWSSYPKTG--------IYSAQEWTSS 323
            :..|      ...||.......|..........|.||    .|...|        .|....:.|.
Human   244 YNGY------GGGPGGGNFGGSPGYGGGRGGYGGGGP----GYGNQGGGYGGGYDNYGGGNYGSG 298

  Fly   324 KVAEWGPKAGHKHAQTSTNDRAKIDLKELQAATFNNKLDFGARGDADRMSGAGLGLGLTGGAAVG 388
            ...::|     .:.|..:|      ...:::..|.     |:|.......|...|.|.:||:. |
Human   299 NYNDFG-----NYNQQPSN------YGPMKSGNFG-----GSRNMGGPYGGGNYGPGGSGGSG-G 346

  Fly   389 VGAIKKW 395
            .|...::
Human   347 YGGRSRY 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbp4	NP_476935.1	RRM_SF	33..110	CDD:302621	40/76 (53%)
Rbp4	NP_476935.1	RRM2_hnRNPA_like	137..209	CDD:240774	24/83 (29%)
HNRNPA2B1	NP_112533.1	Nuclear localization signal. /evidence=ECO:0000255	9..15		1/1 (100%)
		RRM1_hnRNPA2B1	19..99	CDD:410155	41/79 (52%)
		RRM2_hnRNPA2B1	112..191	CDD:409995	23/78 (29%)
		Disordered. /evidence=ECO:0000269\|PubMed:26544936	193..353		37/202 (18%)
		HnRNPA1	302..326	CDD:402981	5/39 (13%)
		Nuclear targeting sequence. /evidence=ECO:0000250	308..347		10/50 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BA81
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1202220at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820