DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rbp4 and TARDBP

DIOPT Version :9

Sequence 1:	NP_476935.1	Gene:	Rbp4 / 41668	FlyBaseID:	FBgn0010258	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_031401.1	Gene:	TARDBP / 23435	HGNCID:	11571	Length:	414	Species:	Homo sapiens

Alignment Length:	407	Identity:	90/407 - (22%)
Similarity:	137/407 - (33%)	Gaps:	133/407 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 DGKTAIK-EEGYEHLRKIFIGGLSTQTTVETLRGFFSQFGIVADAVVLRDPVSNHSRGFGFVTYV 81
            |..:|:| :...:....:.:.||..:||.:.|:.:||.||.|....|.:|..:.||:|||||.:.
Human    89 DASSAVKVKRAVQKTSDLIVLGLPWKTTEQDLKEYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFT 153

  Fly    82 DPKSVEIVQRARPHTIDNKIVETKHALPR----QDFKRGGGVGSVVGSFGCEAGFMNSKRIFLGG 142
            :.:: ::...::.|.||.:..:.|  ||.    ||..                  :.|:::|:|.
Human   154 EYET-QVKVMSQRHMIDGRWCDCK--LPNSKQSQDEP------------------LRSRKVFVGR 197

  Fly   143 LKEYHDENIVREYFSQFGPVASVKLLMDRETGRQRAFGFLEFVDPSSAEK--------------- 192
            ..|...|:.:||:|||:|.|..|.:     ....|||.|:.|.|...|:.
Human   198 CTEDMTEDELREFFSQYGDVMDVFI-----PKPFRAFAFVTFADDQIAQSLCGEDLIIKGISVHI 257

  Fly   193 ALAPRKHWILQTLVEVKRSTQKADRRFRF---PIFSSVRAGYIPPQPATADSYNYNNPN------ 248
            :.|..||          .|.::.:|..||   |.....:.|:...:...|...|....|
Human   258 SNAEPKH----------NSNRQLERSGRFGGNPGGFGNQGGFGNSRGGGAGLGNNQGSNMGGGMN 312

  Fly   249 -----YNPYLAQSVLPPSAFTNGWAHYVIPMAPKPTPGQNMAASLPSQQLAEHSLNGHGPDMWSS 308
                 .||  |......:|..:.|               .|...|.|||      |..||.
Human   313 FGAFSINP--AMMAAAQAALQSSW---------------GMMGMLASQQ------NQSGPS---- 350

  Fly   309 YPKTGIYSAQEWTSSKVAEWGPKAGHKHAQTSTNDRAKIDLKELQAATFNNKLDFGARGDADRMS 373
                                |......:.|...|          ||....|....|:.      |
Human   351 --------------------GNNQNQGNMQREPN----------QAFGSGNNSYSGSN------S 379

  Fly   374 GAGLGLGLTGGAAVGVG 390
            ||.:|.|....|..|.|
Human   380 GAAIGWGSASNAGSGSG 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbp4	NP_476935.1	RRM_SF	33..110	CDD:302621	24/76 (32%)
Rbp4	NP_476935.1	RRM2_hnRNPA_like	137..209	CDD:240774	22/86 (26%)
TARDBP	NP_031401.1	TDP43_N	4..77	CDD:376118
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:18957508	82..98		3/8 (38%)
		RRM1_TDP43	105..181	CDD:240767	25/78 (32%)
		RRM2_TDP43	191..261	CDD:240768	19/74 (26%)
		Interaction with UBQLN2. /evidence=ECO:0000269\|PubMed:23541532	216..414		49/259 (19%)
		Nuclear export signal. /evidence=ECO:0000269\|PubMed:18957508	239..250		1/10 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..303		10/51 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..373		12/71 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910