DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rbp4 and HNRNPA3

DIOPT Version :9

Sequence 1:	NP_476935.1	Gene:	Rbp4 / 41668	FlyBaseID:	FBgn0010258	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_001317178.1	Gene:	HNRNPA3 / 220988	HGNCID:	24941	Length:	378	Species:	Homo sapiens

Alignment Length:	197	Identity:	74/197 - (37%)
Similarity:	119/197 - (60%)	Gaps:	18/197 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 EEGY-----EHLRKIFIGGLSTQTTVETLRGFFSQFGIVADAVVLRDPVSNHSRGFGFVTYVDPK 84
            |||:     |.|||:||||||.:||.::||..|.::|.:.|.||:|||.:..|||||||||...:
Human    23 EEGHDPKEPEQLRKLFIGGLSFETTDDSLREHFEKWGTLTDCVVMRDPQTKRSRGFGFVTYSCVE 87

  Fly    85 SVEIVQRARPHTIDNKIVETKHALPRQDFKRGGGVGSVVGSFGCEAGFMNSKRIFLGGLKEYHDE 149
            .|:....||||.:|.::||.|.|:.|:|..:.|             ..:..|:||:||:||..:|
Human    88 EVDAAMCARPHKVDGRVVEPKRAVSREDSVKPG-------------AHLTVKKIFVGGIKEDTEE 139

  Fly   150 NIVREYFSQFGPVASVKLLMDRETGRQRAFGFLEFVDPSSAEKALAPRKHWILQTLVEVKRSTQK 214
            ..:|:||.::|.:.:::::.||::|::|.|.|:.|.|..:.:|.:..:.|.|.....|||::..|
Human   140 YNLRDYFEKYGKIETIEVMEDRQSGKKRGFAFVTFDDHDTVDKIVVQKYHTINGHNCEVKKALSK 204

  Fly   215 AD 216
            .:
Human   205 QE 206

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbp4	NP_476935.1	RRM_SF	33..110	CDD:302621	38/76 (50%)
Rbp4	NP_476935.1	RRM2_hnRNPA_like	137..209	CDD:240774	23/71 (32%)
HNRNPA3	NP_001317178.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35		4/11 (36%)
		RRM1_hnRNPA_like	36..113	CDD:409992	38/76 (50%)
		RRM2_hnRNPA3	126..205	CDD:409996	26/78 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..225		1/3 (33%)
		HnRNPA1	331..>347	CDD:402981
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	336..378
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BA81
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1202220at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.780