DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rbp4 and exc-7

DIOPT Version :9

Sequence 1:	NP_476935.1	Gene:	Rbp4 / 41668	FlyBaseID:	FBgn0010258	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_496057.1	Gene:	exc-7 / 174506	WormBaseID:	WBGene00001368	Length:	456	Species:	Caenorhabditis elegans

Alignment Length:	375	Identity:	81/375 - (21%)
Similarity:	131/375 - (34%)	Gaps:	107/375 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GDGKTAIKEEGYEHLRKIFIGGLSTQTTVETLRGFFSQFGIVADAVVLRDPVSNHSRGFGFVTYV 81
            |:.||           .:.|..|....|.|.:|..|:..|.:....::||.|:..|.|:|||.||
Worm    38 GESKT-----------NLIINYLPQGMTQEEVRSLFTSIGEIESCKLVRDKVTGQSLGYGFVNYV 91

  Fly    82 -DPKSVEIVQRARPHTIDNKIVETKHALPRQDFKRGGGVGSVVGSFGCEAGFMNSKRIFLGGLKE 145
             :..::..|.......:.||.::..:|.|..|..:|                   ..:::.|:.:
Worm    92 REEDALRAVSSFNGLRLQNKTIKVSYARPSNDQIKG-------------------SNLYVSGIPK 137

  Fly   146 YHDENIVREYFSQFGPVASVKLLMDRETGRQRAFGFLEFVDPSSAEKALAPRKHWILQTL----- 205
            ....:.:...|..||.:.:.::|.|..||..:..||:.|.....|:.|        ::||
Worm   138 SMTLHELESIFRPFGQIITSRILSDNVTGLSKGVGFVRFDKKDEADVA--------IKTLNGSIP 194

  Fly   206 ------VEVKRSTQKADRRFR----------------FPIFS-------SVRAGYIPPQ---PAT 238
                  :.||.:...|....:                .|:.:       ...||.|.|.   |.|
Worm   195 SGCSEQITVKFANNPASNNPKGLLSDLEAVQQAATTLVPLSTILGAPTLRATAGGIGPMHHAPIT 259

  Fly   239 ADSYNY---------NNPNYN---PYLAQSVLPPSAFTNGWAHYVIPMAPKPTPGQNMAASLPSQ 291
            : .|.|         :.|...   .||..|.|...:..|..|. :.|.| ..|...:..|||.:.
Worm   260 S-KYRYSPMGAITAVSQPTATLPADYLTTSALLQMSQLNALAG-LNPFA-TATAVPDFTASLIAH 321

  Fly   292 QLAEHSLNGHGPDMWSSYPKTGIYSAQEWTSSKVAEWGPKAG-HKHAQTS 340
            |..:|::...             ::||  |:|..|..|..|| ..|||.|
Worm   322 QQQQHAVAQQ-------------HAAQ--TASPPATNGQVAGLAAHAQLS 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbp4	NP_476935.1	RRM_SF	33..110	CDD:302621	21/77 (27%)
Rbp4	NP_476935.1	RRM2_hnRNPA_like	137..209	CDD:240774	15/82 (18%)
exc-7	NP_496057.1	ELAV_HUD_SF	39..455	CDD:273741	80/374 (21%)
		RRM1_Hu	41..118	CDD:241094	22/87 (25%)
		RRM2_Hu	128..206	CDD:241096	17/85 (20%)
		RRM3_Hu	373..449	CDD:240823
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910