DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rbp4 and HNRNPA1L2

DIOPT Version :9

Sequence 1:	NP_476935.1	Gene:	Rbp4 / 41668	FlyBaseID:	FBgn0010258	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_001011724.1	Gene:	HNRNPA1L2 / 144983	HGNCID:	27067	Length:	320	Species:	Homo sapiens

Alignment Length:	197	Identity:	75/197 - (38%)
Similarity:	118/197 - (59%)	Gaps:	14/197 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 KTAIKEEGYEHLRKIFIGGLSTQTTVETLRGFFSQFGIVADAVVLRDPVSNHSRGFGFVTYVDPK 84
            |:|..:|. |.|||:||||||.:||.|:||..|.|:|.:.|.||:|||.:..|||||||||...:
Human     3 KSASPKEP-EQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVE 66

  Fly    85 SVEIVQRARPHTIDNKIVETKHALPRQDFKRGGGVGSVVGSFGCEAGFMNSKRIFLGGLKEYHDE 149
            .|:......||.:|.::||.|.|:.|:|.:|.|             ..:..|:||:||:||..:|
Human    67 EVDAAMNTTPHKVDGRVVEPKRAVSREDSQRPG-------------AHLTVKKIFVGGIKEDTEE 118

  Fly   150 NIVREYFSQFGPVASVKLLMDRETGRQRAFGFLEFVDPSSAEKALAPRKHWILQTLVEVKRSTQK 214
            :.:|:||.|:|.:..::::.||.:|::|.|.|:.|.|..|.:|.:..:.|.:.....||:::..|
Human   119 HHLRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVKGHNCEVRKALPK 183

  Fly   215 AD 216
            .:
Human   184 QE 185

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbp4	NP_476935.1	RRM_SF	33..110	CDD:302621	38/76 (50%)
Rbp4	NP_476935.1	RRM2_hnRNPA_like	137..209	CDD:240774	24/71 (34%)
HNRNPA1L2	NP_001011724.1	Globular A domain	4..94		44/90 (49%)
		RRM1_hnRNPA1	12..92	CDD:410154	40/79 (51%)
		Globular B domain	95..185		29/102 (28%)
		RRM_SF	105..184	CDD:418427	26/78 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	181..216		1/5 (20%)
		RNA-binding RGG-box	218..240
		HnRNPA1	255..292	CDD:402981
		Nuclear targeting sequence. /evidence=ECO:0000250	268..305
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	271..320
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BA81
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1202220at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820