Protein Alignment sqd and RBM39

DIOPT Version :10

• Sequence 1: NP_731825.1
• Gene: sqd / 41666
• FlyBaseID: FBgn0263396
• Length: 344
• Species: Drosophila melanogaster
• Sequence 2: NP_909122.1
• Gene: RBM39 / 9584
• HGNCID: 15923
• Length: 530
• Species: Homo sapiens
• Alignment Length: 181
• Identity: 40/181 - (22%)
• Similarity: 85/181 - (46%)
• Gaps: 18/181 - (9%)

  Fly    54 DDRKLFVGGLSWETTEKELRDHFGKYGEIESINVKTDPQTGRSRGFAFIVFTNTEAID------- 111
            |.|.:|...|:.....::|.:.|...|::..:.:.:|..:.||:|.|::.|.:..::.
Human   151 DARTVFCMQLAARIRPRDLEEFFSTVGKVRDVRMISDRNSRRSKGIAYVEFVDVSSVPLAIGLTG 215

  Fly   112 ----------KVSAADEHIINSKKVDPKKAKARHGKIFVGGLTTEISDEEIKTYFGQFGNIVEVE 166
                      :.|.|:::...:...:.:|..|...:::||.|...|:::.::..|..||.|..::
Human   216 QRVLGVPIIVQASQAEKNRAAAMANNLQKGSAGPMRLYVGSLHFNITEDMLRGIFEPFGRIESIQ 280

  Fly   167 MPFDKQKSQRKGFCFITF-DSEQVVTDLLKTPKQKIAGKEVDVKRATPKPE 216
            :..|.:..:.||:.|||| |||.....|.:....::||:.:.|...|.:.:
Human   281 LMMDSETGRSKGYGFITFSDSECAKKALEQLNGFELAGRPMKVGHVTERTD 331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sqd	NP_731825.1	RRM1_hnRNPA_hnRNPD_like	58..129	CDD:409763	13/87 (15%)
		RRM2_hnRNPD_like	137..211	CDD:240775	22/74 (30%)
RBM39	NP_909122.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..146
		SF-CC1	46..518	CDD:273721	40/181 (22%)
		Interaction with JUN. /evidence=ECO:0000250|UniProtKB:Q8VH51	291..406		14/41 (34%)
		Activating domain. /evidence=ECO:0000250|UniProtKB:Q8VH51	291..355		14/41 (34%)
		Interaction with ESR1 and ESR2. /evidence=ECO:0000250|UniProtKB:Q8VH51	355..406
		Interaction with NCOA6. /evidence=ECO:0000250|UniProtKB:Q8VH51	406..530