Protein Alignment sqd and HNRNPA1

DIOPT Version :10

• Sequence 1: NP_731825.1
• Gene: sqd / 41666
• FlyBaseID: FBgn0263396
• Length: 344
• Species: Drosophila melanogaster
• Sequence 2: NP_112420.1
• Gene: HNRNPA1 / 3178
• HGNCID: 5031
• Length: 372
• Species: Homo sapiens
• Alignment Length: 364
• Identity: 131/364 - (35%)
• Similarity: 178/364 - (48%)
• Gaps: 78/364 - (21%)

  Fly    44 NQSAASGQRDDDRKLFVGGLSWETTEKELRDHFGKYGEIESINVKTDPQTGRSRGFAFIVFTNTE 108
            ::|.:..:.:..||||:||||:|||::.||.||.::|.:....|..||.|.|||||.|:.:...|
Human     2 SKSESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVE 66

  Fly   109 AIDKVSAADEHIINSKKVDPKKAKARHG-----------KIFVGGLTTEISDEEIKTYFGQFGNI 162
            .:|....|..|.::.:.|:||:|.:|..           ||||||:..:..:..::.||.|:|.|
Human    67 EVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKI 131

  Fly   163 VEVEMPFDKQKSQRKGFCFITFDSEQVVTDLLKTPKQKIAGKEVDVKRATPKPE----------- 216
            ..:|:..|:...:::||.|:|||....|..::......:.|...:|::|..|.|
Human   132 EVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGR 196

  Fly   217 --NQMMGGMRGG--------PRGGMRGGRGGYGG-RGGYNNQWDGQGSYGGYGGGYGGYG-AGGY 269
              :...||.|||        .|||...||||:|| |||        |.|||.|.||.|:| .|||
Human   197 SGSGNFGGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGG--------GGYGGSGDGYNGFGNDGGY 253

  Fly   270 GDYYAGGYYNGYDYGYDGYGYGG---GFEGNGYGG---------GGGGNMGGGRGGPRGGG---- 318
            |   .||  .||..|..|||.||   |.:|:||||         ||||..|||.|...|||
Human   254 G---GGG--PGYSGGSRGYGSGGQGYGNQGSGYGGSGSYDSYNNGGGGGFGGGSGSNFGGGGSYN 313

  Fly   319 ------------GPKGGGGFNGGKQRG--GGGRQQRHQP 343
                        ||..||.| ||:..|  |||.|...:|
Human   314 DFGNYNNQSSNFGPMKGGNF-GGRSSGPYGGGGQYFAKP 351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sqd	NP_731825.1	RRM1_hnRNPA_hnRNPD_like	58..129	CDD:409763	29/70 (41%)
		RRM2_hnRNPD_like	137..211	CDD:240775	22/73 (30%)
HNRNPA1	NP_112420.1	Globular A domain	4..94		36/89 (40%)
		RRM1_hnRNPA1	12..92	CDD:410154	34/79 (43%)
		Globular B domain	95..185		24/89 (27%)
		RRM2_hnRNPA3	105..184	CDD:409996	23/78 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	182..216		7/33 (21%)
		RNA-binding RGG-box	218..240		15/29 (52%)
		HnRNPA1	312..344	CDD:463312	9/32 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	317..372		13/36 (36%)
		Nuclear targeting sequence (M9)	320..357		13/33 (39%)