Protein Alignment sqd and Tardbp

DIOPT Version :10

• Sequence 1: NP_731825.1
• Gene: sqd / 41666
• FlyBaseID: FBgn0263396
• Length: 344
• Species: Drosophila melanogaster
• Sequence 2: NP_663531.1
• Gene: Tardbp / 230908
• MGIID: 2387629
• Length: 414
• Species: Mus musculus
• Alignment Length: 432
• Identity: 117/432 - (27%)
• Similarity: 168/432 - (38%)
• Gaps: 137/432 - (31%)

  Fly     6 QVDTEINGEDFTKDVTADGPGS-----------------------ENGDAG-------------- 33
            ::.:|.:|......|||..||:                       ...|||
Mouse    17 EIPSEDDGTVLLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGILHAPDAGWGNLVYVVNYPKDN 81

  Fly    34 --AAGSTNGSSDNQSAASGQRDDDRKLFVGGLSWETTEKELRDHFGKYGEIESINVKTDPQTGRS 96
              ....|:.||..:...:.|:..|  |.|.||.|:|||::|:|:|..:||:..:.||.|.:||.|
Mouse    82 KRKMDETDASSAVKVKRAVQKTSD--LIVLGLPWKTTEQDLKDYFSTFGEVLMVQVKKDLKTGHS 144

  Fly    97 RGFAFIVFTNTEAIDKVSAADEHII----------NSKKVDPKKAKARHGKIFVGGLTTEISDEE 151
            :||.|:.||..|...|| .:..|:|          |||:...:..::|  |:|||..|.:::.||
Mouse   145 KGFGFVRFTEYETQVKV-MSQRHMIDGRWCDCKLPNSKQSPDEPLRSR--KVFVGRCTEDMTAEE 206

  Fly   152 IKTYFGQFGNIVEVEMPFDKQKSQRKGFCFITFDSEQVV-----TDLLKTPKQKIAGKEVDVKRA 211
            ::.:|.|:|.:|:|.:|     ...:.|.|:||..::|.     .||:      |.|..|.:..|
Mouse   207 LQQFFCQYGEVVDVFIP-----KPFRAFAFVTFADDKVAQSLCGEDLI------IKGISVHISNA 260

  Fly   212 TPKPENQMMGGMRGGPRGGMRGGRGGYGGRGGYNNQWDGQGSYGGYGGGYGGYGAGGYGDYYAGG 276
            .||..:.         |...|.||.| |..||:.||       ||:|...|| || |.|:...|.
Mouse   261 EPKHNSN---------RQLERSGRFG-GNPGGFGNQ-------GGFGNSRGG-GA-GLGNNQGGN 306

  Fly   277 YYNGYDYG----------------YDGYGYGG---------GFEGN-------------GYGGGG 303
            ...|.::|                ...:|..|         |..||             .:|.|.
Mouse   307 MGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSGNNQSQGSMQREPNQAFGSGN 371

  Fly   304 GGNMGGGRGGPRGGGGPK---GGGGFNGG-------KQRGGG 335
            ....|...|.|.|.|...   .|.|||||       |..|.|
Mouse   372 NSYSGSNSGAPLGWGSASNAGSGSGFNGGFGSSMDSKSSGWG 413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sqd	NP_731825.1	RRM1_hnRNPA_hnRNPD_like	58..129	CDD:409763	32/80 (40%)
		RRM2_hnRNPD_like	137..211	CDD:240775	23/78 (29%)
Tardbp	NP_663531.1	TDP43_N	4..77	CDD:465833	10/59 (17%)
		RRM1_TDP43	105..178	CDD:409760	30/75 (40%)
		RRM2_TDP43	191..261	CDD:409761	24/82 (29%)
		Interaction with UBQLN2. /evidence=ECO:0000250|UniProtKB:Q13148	216..414		59/228 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	261..301		20/58 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	341..414		19/73 (26%)