Protein Alignment side-IV and SIGLEC12

DIOPT Version :9

• Sequence 1: NP_001034052.2
• Gene: side-IV / 41657
• FlyBaseID: FBgn0038156
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: NP_443729.1
• Gene: SIGLEC12 / 89858
• HGNCID: 15482
• Length: 595
• Species: Homo sapiens
• Alignment Length: 501
• Identity: 120/501 - (23%)
• Similarity: 179/501 - (35%)
• Gaps: 120/501 - (23%)

  Fly    45 LLLPLLMLSGISQVCSTYVEQDELMQNLDRPVPLTTVQGVLGRQAMLPCDIS-PQE---RDDAVY 105
            ||||.|:...:..     .||.:.:..:.:.|   |||.  |....:.|..| ||.   ..|.|:
Human     6 LLLPPLLCGRVGA-----KEQKDYLLTMQKSV---TVQE--GLCVSVLCSFSYPQNGWTASDPVH 60

  Fly   106 MVLWFREGDGEPIYNFDVRGRQFGQARLWSSPTAFGTRAHFSSTTHP----AQLKIDNIRIEDEG 166
             ..|||.|| ....|..|......:|      ....||..|.....|    ..|.|.:.|..|.|
Human    61 -GYWFRAGD-HVSRNIPVATNNPARA------VQEETRDRFHLLGDPQNKDCTLSIRDTRESDAG 117

  Fly   167 VYRCRVDFRNSPTRNLKIN-LTVIVPPDRPVIYGQNRHEKAGNVESFSEGNDIVLSCEVSGGRPR 230
            .|...|: |.:...|.|.: |:|.|...:.:: .:.|.|...:| :..||..:.:.|.|.    .
Human   118 TYVFCVE-RGNMKWNYKYDQLSVNVTASQDLL-SRYRLEVPESV-TVQEGLCVSVPCSVL----Y 175

  Fly   231 PNVTWYLDNTAIDESFEQ-------------RPDGKT--INHLSYPNVGRQHLNSRLMCVASNTN 280
            |:..|...:......|::             .|.||.  ..|..:..:|....|:   |..|..:
Human   176 PHYNWTASSPVYGSWFKEGADIPWDIPVATNTPSGKVQEDTHGRFLLLGDPQTNN---CSLSIRD 237

  Fly   281 LTPPNNRVVILDVN---------LKPIAVHI--LTKDRFVSADRTYDVECKSSG-------SKP- 326
            ....::......|.         ...::||:  ||.....|...|.:     ||       |.|
Human   238 ARKGDSGKYYFQVERGSRKWNYIYDKLSVHVTALTHMPTFSIPGTLE-----SGHPRNLTCSVPW 297

  Fly   327 ------PALITWWKGSKQLKKLTKNFNEPDNQSLSILTFTPGREDDGKYLTCRAENQFIDGSAI- 384
                  |..|||...|  :..|     :|.....|:|:..|..:|.|..|||:..   :.|:.:
Human   298 ACEQGTPPTITWMGAS--VSSL-----DPTITRSSMLSLIPQPQDHGTSLTCQVT---LPGAGVT 352

  Fly   385 -EDKWRLIVHYQP--------------TTTLKIGSSLNPDDIKEGDDAYFECIVLANPKPYKMSW 434
             ....||.:.|.|              :|||:.||:|:   :.||...:..|.|.:|| |.::||
Human   353 MTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALS---VLEGQSLHLVCAVDSNP-PARLSW 413

  Fly   435 FHNGKELQHNISA--GVILSDQSLVLQSVSRASAGDYTCLAVNSEG 478
            ......|..:.|:  ||      |.|..|.....|::||.|.|..|
Human   414 TWGSLTLSPSQSSNLGV------LELPRVHVKDEGEFTCRAQNPLG 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
side-IV	NP_001034052.2	V-set	79..188	CDD:284989	33/117 (28%)
		IG_like	80..188	CDD:214653	33/116 (28%)
		Ig	210..281	CDD:299845	15/85 (18%)
		Ig	319..392	CDD:299845	22/88 (25%)
		IG_like	319..383	CDD:214653	20/77 (26%)
		IG_like	412..489	CDD:214653	22/69 (32%)
		IGc2	413..478	CDD:197706	21/66 (32%)
		Ig_3	509..572	CDD:290638
		fn3	593..675	CDD:278470
SIGLEC12	NP_443729.1	Ig	24..142	CDD:325142	35/131 (27%)
		Ig	151..269	CDD:325142	21/125 (17%)
		Ig	232..345	CDD:325142	27/124 (22%)
		IG_like	389..462	CDD:214653	23/75 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	512..560
		ITIM motif	563..568
		SLAM-like motif	586..591

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000