DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side-IV and NPHS1

DIOPT Version :9

Sequence 1:	NP_001034052.2	Gene:	side-IV / 41657	FlyBaseID:	FBgn0038156	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_004637.1	Gene:	NPHS1 / 4868	HGNCID:	7908	Length:	1241	Species:	Homo sapiens

Alignment Length:	932	Identity:	198/932 - (21%)
Similarity:	302/932 - (32%)	Gaps:	315/932 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 HPAQLKIDNI----RIEDEGV-YRC--------RVDFRNSPTRNLKI---NLTVIVPPDRPVIYG 199
            |...:.:.|:    |.||.|: ..|        :..|:.|...|:|.   .|.:..||:     |
Human   393 HGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPE-----G 452

  Fly   200 QNRHEKAGNVESFSEGNDIVLSCEVSGGRPRPNVTWYLDNTAIDESFEQRPDGKTINHLSYPNVG 264
            |          ....|..:.|.|...||.|.|::.||.|:..:.||  :.|......||......
Human   453 Q----------KLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTES--RLPQESRRVHLGSVEKS 505

  Fly   265 RQHLNSRLMCVASNTNLTPPNNRVVI------------LDVNLKPIAVHILTKDRFVSADRTYDV 317
            ....:..|:.|..     |.:|:...            |.|...|..|.||.....:......::
Human   506 GSTFSRELVLVTG-----PSDNQAKFTCKAGQLSASTQLAVQFPPTNVTILANASALRPGDALNL 565

  Fly   318 ECKSSGSKPPALITWWKGSKQLKKLTKNFNEPDNQ--------SLSILTFTPGREDDGKYLTCRA 374
            .|.|..|.||..::|.|..::|:.:.    .|..:        :.|:|.....| |.|:.:||||
Human   566 TCVSVSSNPPVNLSWDKEGERLEGVA----APPRRAPFKGSAAARSVLLQVSSR-DHGQRVTCRA 625

  Fly   375 ENQFIDGSAIEDKWRLIVHYQP---------TTTLKIGSSLNPDDIKEGDDAYFECIVLANPKPY 430
            .:..: ...:...:||.|.|:|         .|.::.|.:|.|..:.            |||.|.
Human   626 HSAEL-RETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVS------------ANPAPE 677

  Fly   431 KMSWFHNGKEL------QHNISAGVILSDQSLVLQSVSRASAGDYTCLAVNSEGKGPSNPVTLRI 489
            ..:|...|..|      :|.     |||..:|.|.:|:||..|.|.....||||...:. :.|.:
Human   678 AFNWTFRGYRLSPAGGPRHR-----ILSSGALHLWNVTRADDGLYQLHCQNSEGTAEAR-LRLDV 736

  Fly   490 RYAP-------------------ICATDHEELL-----------------------------GAL 506
            .|||                   :|..|...:|                             |.|
Human   737 HYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRL 801

  Fly   507 K--HETL----PLKCEVDS--SPPA---------------------------DS----------- 525
            :  |..|    ..:|.||:  :|||                           ||
Human   802 RIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRAR 866

  Fly   526 ------FQWTFNS---------SGEQTELPARLHSSETGMSRLNYTPSTDLDYGTISCWAKNSIG 575
                  |.||.|.         ..|.|.....:|||...::.:    |...||...:|.|.|::|
Human   867 GVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANV----SAAQDYALFTCTATNALG 927

  Fly   576 TQKSPCVFQIVAAGRPFPLQNCSVTNQSVDSLQVDCLEGFDGGLPQGFMLELVELNTLRLARNIT 640
            :.::.  .|:|:..||.|.....|.:.:..|:.::...||||||||.|.:....|.|........
Human   928 SDQTN--IQLVSISRPDPPSGLKVVSLTPHSVGLEWKPGFDGGLPQRFCIRYEALGTPGFHYVDV 990

  Fly   641 VSHTPVTFVIDNLDQAATYRMVIFAVNA--------KGRSEPTIIDDINFKGVAKFTG------- 690
            |.....||.:..|..:..||:.:.|.||        ||...|     |...|:.:.:|
Human   991 VPPQATTFTLTGLQPSTRYRVWLLASNALGDSGLADKGTQLP-----ITTPGLHQPSGEPEDQLP 1050

  Fly   691 ---ASTGLSMPLSPF---LAGLTLF----C--GLLFAIFCIMLA----------AIYRRISNRRS 733
               .|....:||.|.   |.||.|.    |  |:|:......||          :...|:.|...
Human  1051 TEPPSGPSGLPLLPVLFALGGLLLLSNASCVGGVLWQRRLRRLAEGISEKTEAGSEEDRVRNEYE 1115

  Fly   734 DSNLKVAKHTQLTIPADCQLDPLHPGVQTDGSGNHQPHHSLLPLNCDGRNAVDCGALGDVGGGGV 798
            :|.....:.||.:..:..:.:|.:..:: |.|....|...
Human  1116 ESQWTGERDTQSSTVSTTEAEPYYRSLR-DFSPQLPPTQE------------------------- 1154

  Fly   799 GVGLDGGIKGSSPIGLVAMPG--------------------DTLRSNARNRHSP---------MA 834
            .|....|..|....  :|.||                    |.::....:.|.|         :.
Human  1155 EVSYSRGFTGEDED--MAFPGHLYDEVERTYPPSGAWGPLYDEVQMGPWDLHWPEDTYQDPRGIY 1217

  Fly   835 DQ--ADIDDTDPDVIPNQYEKR 854
            ||  .|:|..:||.:|  :|.|
Human  1218 DQVAGDLDTLEPDSLP--FELR 1237

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-IV	NP_001034052.2	V-set	79..188	CDD:284989	12/52 (23%)
		IG_like	80..188	CDD:214653	12/52 (23%)
		Ig	210..281	CDD:299845	17/70 (24%)
		Ig	319..392	CDD:299845	20/80 (25%)
		IG_like	319..383	CDD:214653	18/71 (25%)
		IG_like	412..489	CDD:214653	23/82 (28%)
		IGc2	413..478	CDD:197706	20/70 (29%)
		Ig_3	509..572	CDD:290638	23/121 (19%)
		fn3	593..675	CDD:278470	25/89 (28%)
NPHS1	NP_004637.1	V-set	38..119	CDD:284989
		IG_like	38..113	CDD:214653
		C2-set_2	141..228	CDD:285423
		Ig	240..321	CDD:299845
		IG_like	254..336	CDD:214653
		Ig	345..424	CDD:299845	7/30 (23%)
		Ig	445..530	CDD:299845	23/106 (22%)
		I-set	446..541	CDD:254352	24/116 (21%)
		Ig	549..632	CDD:299845	20/88 (23%)
		IG_like	558..642	CDD:214653	20/89 (22%)
		I-set	646..736	CDD:254352	28/107 (26%)
		Ig	662..736	CDD:299845	26/91 (29%)
		Ig_3	739..820	CDD:290638	11/80 (14%)
		IG_like	748..821	CDD:214653	10/72 (14%)
		Ig8_hNephrin_like	834..942	CDD:143250	21/113 (19%)
		IG_like	845..935	CDD:214653	18/95 (19%)
		fn3	942..1023	CDD:278470	23/80 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1025..1057		7/36 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1099..1137		5/37 (14%)
		Binds to NPHS2	1160..1241		17/82 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810