DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side-IV and hbs

DIOPT Version :9

Sequence 1:	NP_001034052.2	Gene:	side-IV / 41657	FlyBaseID:	FBgn0038156	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001286439.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0029082	Length:	1235	Species:	Drosophila melanogaster

Alignment Length:	861	Identity:	187/861 - (21%)
Similarity:	287/861 - (33%)	Gaps:	229/861 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 SGISQVCSTYVEQDELMQNLDRPVPL-----TTV-------------QGVLGRQAMLPC---DIS 96
            :|.:.||..        :||....||     .||             |..:|....|.|   ..:
  Fly   317 NGANLVCEA--------KNLLATTPLRAELNLTVLYAPKDVYLSGANQAKVGDSVQLSCVTAPSN 373

  Fly    97 PQERDDAVYMVLWFREGDGEPIYNFDVRGRQFGQARLWSSPTAFGTRAHFSSTTHPAQLKIDNIR 161
            ||.|      :.|  ..:|.|:.|...:........ |.|.:.........|.|..|.....|..
  Fly   374 PQAR------ISW--SINGRPLDNSTYKTTSSSDGG-WVSSSNISLTIDSQSRTFIAVCHALNTE 429

  Fly   162 IEDEGVYRCRVDFRNSPTRNLKINLTVIVPPDRPVIYGQNRHEKAGNVESFSEGNDIVLSCEVSG 226
            :....|        .|.|.|      |:.||..|::.|.|    .|::  ...|:.:.|.|..:|
  Fly   430 LTQNVV--------GSHTVN------VLYPPSPPLLTGYN----DGDI--LISGSILKLQCSSAG 474

  Fly   227 GRPRPNVTWYLDNTAIDESFEQRPDGKTINHLSYPNVGRQHLNSRLMCVASNTNLTPPNNRVVIL 291
            |.|.|.:.|| .|..|..:..:..|.|..:.||. .|.....|:...|...|..:..|......|
  Fly   475 GNPPPTLQWY-KNDKIINAPSKLVDSKITSELSL-LVNASDNNAIYKCKVQNAAIDIPLFATKTL 537

  Fly   292 DVNLKPIAVHILTKDRFVSADRTYDVECKSSGSKPPALITWWKGSKQLKKLTKNFNEPDNQSLSI 356
            .|:..|..|.|....:.:.......:.|.||.|.|||.|:|||....::.|.. .|.|.....|:
  Fly   538 GVHFPPETVKISVVPKNLVPGIRAKLICDSSSSNPPAKISWWKDGIPVEGLNL-ANRPGLWGGSV 601

  Fly   357 LT---FTPGRED-DGKYLTCRAENQFIDGSAIEDKWRLIVHY-----QPTTTLKIGSSLNPDDIK 412
            .|   :....:| ||...||::.|:.:..| :.:...|.:.|     .|.:|..:|        .
  Fly   602 STLEMYVNITQDLDGIVYTCQSHNEVLQRS-VHETISLDILYPPKFETPQSTTFVG--------V 657

  Fly   413 EGDDAYFECIVLANPKPYKMSWFHNGKELQHN-ISAGVILSD-QSLVLQSVSRASAGDYTCLAVN 475
            ||...:.|.:...||.....:|..:|..:..| :|...::|| ..|.:..:||..||.|.|.|:|
  Fly   658 EGAPFHVELLASGNPMVITYTWTKDGLPISSNSLSGQRLISDGPRLNISRLSRNDAGVYICEALN 722

  Fly   476 SEGKGPSNPVTLRIRYAP----------------------------------------------- 493
            |:|..... :.:.:.|||
  Fly   723 SQGTALLE-IQVAVEYAPTITAVSEGRSFVAGEPAVLACHIQARPLEAAHVRWSRDGYDLATRTI 786

  Fly   494 -----------------------ICATDHEELLGALKH-----ETLPLKCEVDSSP--------- 521
                                   .|..|::....|.::     :|.|   |:|.||
  Fly   787 SSFENGTALLQIASVERSDIGNFTCIVDNQRGAPAAQNVLLVVQTAP---EIDHSPGFTRYAARL 848

  Fly   522 -------------PADSFQWTFNSSGEQTELPARLHSSETGMSRLNY-------TPSTDLDYGTI 566
                         |..||.|..:....:.:...:..|.|..:..||:       ..|.| |||..
  Fly   849 GVRAQLICRSLASPQPSFIWRRHGKDLKMQRRNKFKSVERQVDALNFESALLIENTSPD-DYGQY 912

  Fly   567 SCWAKNSIGTQKSPCVFQIVAAGRP-FPLQNCSVTNQSVDSLQVDCLEGFDGGLPQGFMLELVE- 629
            .|..:||:|...:...|.  ...|| .||| ..|.|.|...:.::...|||||:...|.|.|.:
  Fly   913 ECVVRNSLGQASTTLEFS--KPSRPDAPLQ-LRVGNVSDTGVDLNWTPGFDGGMQTYFRLRLKQH 974

  Fly   630 -------LNTLRLARNITVSHTPVTFVIDNLDQAATYRMVIFAVNAKGRSEPTIIDDINF---KG 684
                   ::.....:||:         :|.|...|||...:.|.|..|.|:  .:.||..   ||
  Fly   975 GEDKYKYVDAKPGHQNIS---------LDGLKPGATYYFSVMAANEAGGSK--FMPDIKLTLSKG 1028

  Fly   685 VAKFTGASTGLSMPLSPFLAGLTLFCGLLFAIFCIMLA-AIYRRISNRRS------------DSN 736
            ....:...|......:..:.|:|....:|..:...::| .:.||.:..:|            |.:
  Fly  1029 SQPHSAEYTEKDELPNVMIIGITSAAMVLLVLNAALVAWFVIRRQNKSQSEAEPSNDDVYSKDDS 1093

  Fly   737 LKVAKHTQLTIPADCQ 752
            ..|.|.....:.||.|
  Fly  1094 QSVYKLPITALQADVQ 1109

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-IV	NP_001034052.2	V-set	79..188	CDD:284989	23/124 (19%)
		IG_like	80..188	CDD:214653	23/123 (19%)
		Ig	210..281	CDD:299845	19/70 (27%)
		Ig	319..392	CDD:299845	24/76 (32%)
		IG_like	319..383	CDD:214653	22/67 (33%)
		IG_like	412..489	CDD:214653	22/78 (28%)
		IGc2	413..478	CDD:197706	21/66 (32%)
		Ig_3	509..572	CDD:290638	20/91 (22%)
		fn3	593..675	CDD:278470	25/89 (28%)
hbs	NP_001286439.1	Ig	44..122	CDD:299845
		IG_like	45..137	CDD:214653
		Ig	153..231	CDD:299845
		IG_like	258..342	CDD:214653	7/32 (22%)
		Ig	266..327	CDD:299845	3/17 (18%)
		IG_like	357..>414	CDD:214653	12/65 (18%)
		Ig	360..427	CDD:299845	15/75 (20%)
		Ig	<468..526	CDD:299845	18/59 (31%)
		I-set	547..633	CDD:254352	24/87 (28%)
		Ig	556..631	CDD:299845	22/75 (29%)
		I-set	644..735	CDD:254352	25/99 (25%)
		IGc2	668..725	CDD:197706	18/56 (32%)
		IG_like	751..829	CDD:214653	3/77 (4%)
		IGc2	753..815	CDD:197706	1/61 (2%)
		Ig	852..928	CDD:143165	17/76 (22%)
		FN3	935..1017	CDD:238020	26/93 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810