DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side-IV and side-VII

DIOPT Version :9

Sequence 1:	NP_001034052.2	Gene:	side-IV / 41657	FlyBaseID:	FBgn0038156	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001262432.1	Gene:	side-VII / 41184	FlyBaseID:	FBgn0037736	Length:	939	Species:	Drosophila melanogaster

Alignment Length:	981	Identity:	323/981 - (32%)
Similarity:	490/981 - (49%)	Gaps:	155/981 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 LPLLMLSGISQVCSTYVEQDELMQNLDRPVPLTTVQGVLGRQAMLPCDISPQERDDAVYMVLWFR 111
            |.||.:..:..:.|:...:|         ||:..::.::|....|||:::..:.|:.| :|||:|
  Fly     3 LLLLFMLALQLIESSIGSKD---------VPIHQIESIVGENIYLPCNVTTYDGDEPV-LVLWYR 57

  Fly   112 EGDGEPIYNFDVRGRQFGQARLWSSPTAFGTRAHFSSTTHPAQLKIDNIRIEDEGVYRCRVDFRN 176
            :..|.|||:.|:|.......:.||..:.||.||:|.....|.:|.|.|.:..|.|.|||||||..
  Fly    58 DDKGTPIYSIDIRAGVSKAPKRWSDDSVFGDRAYFIFDKEPGKLSIQNTQASDSGTYRCRVDFLK 122

  Fly   177 SPTRNLKINLTVIVPPDRPVIYGQNRHEKAGNVESFSEGNDIVLSCEVSGGRPRPNVTWYLDNTA 241
            :.|.|.:|.|.||.||.:.:|...:..|::..|..:|||:.:.|.|:|.||.|.|.::||.|...
  Fly   123 AQTINSRIRLNVISPPKQVIIRDSSNVERSTVVGPYSEGDIVSLKCQVIGGYPTPTISWYRDGIE 187

  Fly   242 IDESFEQRPDGKTIN-HLSYPNVGRQHLNSRLMCVASNTNLTPPNNRVVILDVNLKPIAVHILTK 305
            |.........||.|. .::.|::||:.|||||.|.|.:....|....||.:|:|..|:.:.:|..
  Fly   188 IPCELSHLAGGKIIECEITLPSLGREDLNSRLTCRALSHPRAPIVEAVVQIDMNFAPLNIRLLGA 252

  Fly   306 DRFVSADRTYDVECKSSGSKPPALITWWKGSKQLKKLTKNFNEPDNQSLSILTFTPGREDDGKYL 370
            .:.:||.|.||:.|:|:||:|||:||||:...:|:|.|:..:...||:.|.|:.:..:.|.||||
  Fly   253 HQPLSAGRRYDLLCQSAGSRPPAVITWWQNGIRLEKTTETTSSDGNQTTSTLSISLSKSDAGKYL 317

  Fly   371 TCRAENQFIDGSAIEDKWRLIVHYQPTTTLKIGSSLNPDDIKEGDDAYFECIVLANPKPYKMSWF 435
            :|:|.|..:....:||.|:|.:.|.|...:::|:||:|..::||.|.||:|:|:|:|..:::.|.
  Fly   318 SCKAYNHAVPSEPLEDGWKLDIQYVPEAYVRLGTSLDPSTLREGTDVYFDCLVMAHPNVFRIEWR 382

  Fly   436 HNGKELQHNISAGVILSDQSLVLQSVSRASAGDYTCLAVNSEGKGPSNPVTLRIRYAPICATDHE 500
            ||.:.|.||||.|||:|:.|||||.|:||:||:|:|:..|:||:|.|.|..|.|.|||.||.:.:
  Fly   383 HNEQPLSHNISLGVIISNHSLVLQGVTRATAGNYSCVGFNAEGEGISAPFALNILYAPTCAQNQK 447

  Fly   501 ELLGALKHETLPLKCEVDSSPPADSFQWTFNSSGEQTELPARLHSSETG-MSRLNYTPSTDLDYG 564
            ::.|..|.|...:.|.||::|....|.||||:|.|..:: |..|...:| .|.:.|||.|:||||
  Fly   448 KVYGIAKQEDAKVMCTVDANPREVEFSWTFNNSAESIDV-ATNHIIRSGTTSIVTYTPITELDYG 511

  Fly   565 TISCWAKNSIGTQKSPCVFQIVAAGRPFPLQNCSVTNQSVDSLQVDCLEGFDGGLPQGFMLELVE 629
            |:.|.|.|.||.|:.||||.|:|||||..:.||:|.|.|:.||.|.|.:||:|||||.|.|||::
  Fly   512 TLLCLASNKIGKQRVPCVFHIIAAGRPEKVHNCTVNNISMTSLTVTCSDGFNGGLPQSFNLELLD 576

  Fly   630 LNTLRLARNITVSHTPVTFVIDNLDQAATYRMVIFAVNAKGRSEPTIIDDINFKGVAK-FTGAST 693
            ..|..:..|||  .|...|.:..|...:.||:.|:|.|.||||:|.|::....:...| .|...|
  Fly   577 SYTQEIKANIT--STIPKFTVPGLSPGSIYRLNIYAFNTKGRSDPAIVNAAMLRMPEKQLTSEQT 639

  Fly   694 G------LSMPLSPFLAGLTLFCGLLFAIFCIMLA------AIYRRISNRRSDSNLKVAKHTQLT 746
            .      |..|:.....||||  .:|.|:..|:||      |..||.....|:.|:...:
  Fly   640 HNLRAELLFSPVMSLTIGLTL--AVLVAVLAIILALRIPCTASSRRRQKELSNENISRDE----- 697

  Fly   747 IPADCQLDPLHPGVQTDGSGNHQPHHSLLPLNCDGRNAVDCGALGDVGGGGVGVGLDGGIKGSSP 811
                      .||.....||:.:               ||
  Fly   698 ----------SPGPSDKSSGSKE---------------VD------------------------- 712

  Fly   812 IGLVAMPGDTLRSNARNRHSPMADQADIDDTDPDVIPNQYE---------KRPLKSLVSPPGFAS 867
                                      |.|:.:|||:|...|         ||...|.:...  .|
  Fly   713 --------------------------DCDEKNPDVVPESIEPDEQAESIRKRQQISTIDTN--RS 749

  Fly   868 PSNRLM--QRDYLRETELTKGGSDVGMG--------AAEGLSSIGLMSSSGNEVLHYTFRPSKQI 922
            |:..:.  ::.:|...|::...|. |:|        .|:..||:|.:|.:   |..:.:  |..|
  Fly   750 PNRGIFVNEQQHLTAAEISLRASH-GIGYCTLRSGMHAQAQSSVGEISIN---VTPHVY--SNSI 808

  Fly   923 SYATLNKKGITTCSPPLGSLNYSVSTSTPTSSYH-LT-------------PQPMEVSLLSPNNPS 973
            |..||.::   :......:.|.:::.:.|||::| ||             .||:.....||:..|
  Fly   809 SQCTLPRQ---SSQNVWNNYNCNITGARPTSTFHQLTFPQGRVNVGGHNPAQPLHGHAPSPSQAS 870

  Fly   974 VTSSLS 979
            .:|..|
  Fly   871 NSSMAS 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-IV	NP_001034052.2	V-set	79..188	CDD:284989	40/108 (37%)
		IG_like	80..188	CDD:214653	40/107 (37%)
		Ig	210..281	CDD:299845	27/71 (38%)
		Ig	319..392	CDD:299845	30/72 (42%)
		IG_like	319..383	CDD:214653	26/63 (41%)
		IG_like	412..489	CDD:214653	40/76 (53%)
		IGc2	413..478	CDD:197706	34/64 (53%)
		Ig_3	509..572	CDD:290638	27/63 (43%)
		fn3	593..675	CDD:278470	36/81 (44%)
side-VII	NP_001262432.1	IG_like	32..134	CDD:214653	40/102 (39%)
		V-set	32..134	CDD:284989	40/102 (39%)
		IGc2	160..>214	CDD:197706	19/53 (36%)
		Ig	262..328	CDD:299845	28/65 (43%)
		IG_like	264..323	CDD:214653	25/58 (43%)
		IGc2	360..425	CDD:197706	34/64 (53%)
		Ig_3	456..519	CDD:290638	27/63 (43%)
		FN3	538..620	CDD:238020	37/83 (45%)
		FAM176	643..741	CDD:291517	31/180 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470108
Domainoid	1	1.000	41	1.000	Domainoid score	I12487
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D23448at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23278
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1676
	7	6.850