DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side-IV and MAG

DIOPT Version :9

Sequence 1:	NP_001034052.2	Gene:	side-IV / 41657	FlyBaseID:	FBgn0038156	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_002352.1	Gene:	MAG / 4099	HGNCID:	6783	Length:	626	Species:	Homo sapiens

Alignment Length:	726	Identity:	139/726 - (19%)
Similarity:	238/726 - (32%)	Gaps:	240/726 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 TTVQGVLGRQAMLPCDIS-PQERDDAVYMVLWFREGDGEPIY--------------NFDVRGRQF 128
            :::....|....:||... |.|...||...:|:........|              :|..|.|..
Human    28 SSISAFEGTCVSIPCRFDFPDELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLL 92

  Fly   129 GQARLWSSPTAFGTRAHFSSTTHPAQLKIDNIRIEDEGVYRCR----------------VDFRNS 177
            |...|                 ....|.:.|:..|..|.|..|                :|..|:
Human    93 GDLGL-----------------RNCTLLLSNVSPELGGKYYFRGDLGGYNQYTFSEHSVLDIVNT 140

  Fly   178 PTRNLKINLTVIVPPDRPVIYGQNRHEKAGNVESFSEGNDIVLSCEVSGGRP--RPNVTWYLDNT 240
            |        .::|||:  |:                .|.::.:||.|....|  ||.::|
Human   141 P--------NIVVPPE--VV----------------AGTEVEVSCMVPDNCPELRPELSW----- 174

  Fly   241 AIDESFEQRPDGKTINHLSYPNVGRQHLNSRLMCVASNTNLTPPNNRVVILDVNLKPIAVHILTK 305
                             |.:..:|...:..||.
Human   175 -----------------LGHEGLGEPAVLGRLR-------------------------------- 190

  Fly   306 DRFVSADRTYDVECKSSGSKPPALITWWKGSKQLKKLTKNFNEPDNQSLSILTFTPGREDDGKYL 370
                          :..|       ||                   ..:|:|.|.|.||.:|..|
Human   191 --------------EDEG-------TW-------------------VQVSLLHFVPTREANGHRL 215

  Fly   371 TCRAE-----NQFIDGSAIEDKWRLIVHYQPTTTLKIGSSLNPDDIKEGDDAYFECIVLANPKPY 430
            .|:|.     .|| :|.|..|     |.| |...:::.||:   :..||......|...:||.|.
Human   216 GCQASFPNTTLQF-EGYASMD-----VKY-PPVIVEMNSSV---EAIEGSHVSLLCGADSNPPPL 270

  Fly   431 KMSWFHNGKELQHNISAGVILSDQSLVLQSVSRASAGDYTCLAVNSEGKGPSNPVTLRIRYAPIC 495
             ::|..:|..|:..::..::|.     |:.|:.|..|.|.|||.|:.|: .:..|.|.:.|||..
Human   271 -LTWMRDGTVLREAVAESLLLE-----LEEVTPAEDGVYACLAENAYGQ-DNRTVGLSVMYAPWK 328

  Fly   496 ATDHEELLGALKHETLPLKCEVDSSPPADSFQWTFNSSGEQTELPARLHSSETGMSRLNYTPSTD 560
            .|.:..:: |::.||:.:.|...|:|  |.....|.   |:..|...::.||..:.....:|..|
Human   329 PTVNGTMV-AVEGETVSILCSTQSNP--DPILTIFK---EKQILSTVIYESELQLELPAVSPEDD 387

  Fly   561 LDYGTISCWAKNSIGTQKSPCVFQIVAAGRPFPL--QNCSVTNQSVDSLQVDCLEGFDGGLPQGF 623
            .:|.   |.|:|..|.:.:  .|.:.....|..|  .:|:...   |::|..|:...:......|
Human   388 GEYW---CVAENQYGQRAT--AFNLSVEFAPVLLLESHCAAAR---DTVQCLCVVKSNPEPSVAF 444

  Fly   624 MLELVELNTLRLARNITVSHTPVTFVIDNLDQAATYRMVIFAVNAKGRSEPTIID---------- 678
            .|.         :||:||:.:...||..  :::......|..:..:.::.|.:|.
Human   445 ELP---------SRNVTVNESEREFVYS--ERSGLVLTSILTLRGQAQAPPRVICTARNLYGAKS 498

  Fly   679 -DINFKGVAKFTGASTGLSMPLSPFLAGLTLFCGLLFAIFCIMLAAIYRRISNRRSDSNLKVAKH 742
             ::.|:|..:...|..|   |:     |..:...:|.||.|.:...  ||..|.....:.....:
Human   499 LELPFQGAHRLMWAKIG---PV-----GAVVAFAILIAIVCYITQT--RRKKNVTESPSFSAGDN 553

  Fly   743 TQLTIPADCQL 753
            ..:...:|.::
Human   554 PPVLFSSDFRI 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-IV	NP_001034052.2	V-set	79..188	CDD:284989	23/139 (17%)
		IG_like	80..188	CDD:214653	23/138 (17%)
		Ig	210..281	CDD:299845	12/72 (17%)
		Ig	319..392	CDD:299845	18/77 (23%)
		IG_like	319..383	CDD:214653	16/68 (24%)
		IG_like	412..489	CDD:214653	22/76 (29%)
		IGc2	413..478	CDD:197706	19/64 (30%)
		Ig_3	509..572	CDD:290638	16/62 (26%)
		fn3	593..675	CDD:278470	14/83 (17%)
MAG	NP_002352.1	Interaction with RTN4R and RTN4RL2. /evidence=ECO:0000250\|UniProtKB:P07722	20..325		84/450 (19%)
		Ig_Siglec_N	22..139	CDD:143189	21/127 (17%)
		Ganglioside GT1b binding. /evidence=ECO:0000250\|UniProtKB:P20917	65..67		0/1 (0%)
		Ganglioside GT1b binding. /evidence=ECO:0000250\|UniProtKB:P20917	124..128		0/3 (0%)
		Ig	141..223	CDD:325142	30/201 (15%)
		Ig_3	239..309	CDD:316449	21/78 (27%)
		IG_like	333..409	CDD:214653	20/86 (23%)
		Required for normal axon myelination in the central nervous system. /evidence=ECO:0000250\|UniProtKB:P20917	577..626
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	582..608
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000