DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side-IV and fred

DIOPT Version :9

Sequence 1:	NP_001034052.2	Gene:	side-IV / 41657	FlyBaseID:	FBgn0038156	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_608812.3	Gene:	fred / 33613	FlyBaseID:	FBgn0051774	Length:	1447	Species:	Drosophila melanogaster

Alignment Length:	1261	Identity:	242/1261 - (19%)
Similarity:	385/1261 - (30%)	Gaps:	459/1261 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 TAPHPFPSPNVWRQLLLPLLMLSGISQVCSTYVEQDELMQNLDRPVPLT--TVQGVLGRQAMLPC 93
            |||||            |::....::      |..:|      :|:.||  ::.|
  Fly   127 TAPHP------------PMVTPGNLA------VATEE------KPLELTCSSIGG---------- 157

  Fly    94 DISPQERDDAVYMVLWFREGDGEPIYNFDVRGRQFGQARLWSSPTAFGTRAHFSSTTHPAQLKID 158
              ||..      |:.|:|||...|:.::.::|               |::.|:::.|    |:|.
  Fly   158 --SPDP------MITWYREGSTVPLQSYALKG---------------GSKNHYTNAT----LQIV 195

  Fly   159 NIRIEDEGVYRCRVDFRNSP---------TRNLKINLTVIVPPDRPVIYGQNRHEKAGNVESFSE 214
            ..|.:|...|:|.|..|..|         |.|:.....|.|.|..|:...::...|
  Fly   196 PRRADDGAKYKCVVWNRAMPEGHMLETSVTLNVNYYPRVEVGPQNPLKVERDHVAK--------- 251

  Fly   215 GNDIVLSCEVSGGRPRPNVTWYLDNTAIDESFEQRPDGKTINHLSYPNVGRQHLNSRLMCVASNT 279
                 |.|.|.......||.|..:...:         ..|..|..| .|.|.|. .:..|.|.|
  Fly   252 -----LDCRVDAKPMVSNVRWSRNGQYV---------SATPTHTIY-RVNRHHA-GKYTCSADN- 299

  Fly   280 NLTPPNNRVVILDVNLKPIAVHILTKDRFVSADRTYDVECKSSGSKPPALITWWK---------- 334
            .|.....:.::|||...|| |.|.:|........|..:.|..:.:..|..:.|.|
  Fly   300 GLGKTGEKDIVLDVLYPPI-VFIESKTHEAEEGETVLIRCNVTANPSPINVEWLKEGAPDFRYTG 363

  Fly   335 -----GSKQLKKL------TKNFNEP---------DNQSLSILT--------FTPGRE----DDG 367
                 ||.:.:..      :.|..:|         .|.::::|.        .||.:.    .:|
  Fly   364 ELLTLGSVRAEHAGNYICRSVNIMQPFSSKRVEGVGNSTVALLVRHRPGQAYITPNKPVVHVGNG 428

  Fly   368 KYLTCRAE------NQF-----IDGS---------------------AIEDKWR----------- 389
            ..|||.|.      .|:     :||.                     ..|.|:.
  Fly   429 VTLTCSANPPGWPVPQYRWFRDMDGDIGNTQKILAQGPQYSIPKAHLGSEGKYHCHAVNELGIGK 493

  Fly   390 -----LIVHYQPTTTLKIGSSLNPDDIKEGD-DAYFECIVLANPKPYKMSWFHNGKEL------- 441
                 |.||..|....|:...:..   :.|| |....|.....|.| ::.|..:|.|:
  Fly   494 IATIILEVHQPPQFLAKLQQHMTR---RVGDVDYAVTCSAKGKPTP-QIRWIKDGTEILPTRKMF 554

  Fly   442 -----QHNISAGVILSDQSLVLQSVSRASA--------GDYTCLAVNSEGKGPSNPVTLRIRYAP 493
                 ..:...||:.....|..:..:|.:.        |.||||..|......|: :.|||.:.|
  Fly   555 DIRTTPTDAGGGVVAVQSILRFRGKARPNGNQLLPNDRGLYTCLYENDVNSANSS-MHLRIEHEP 618

  Fly   494 ICATDHEELLGALKHETLPLKCEVDSSPPADSFQWTFN--------SSGEQTELPARLHSSETGM 550
            |....:.::...|: |:..:.|.|.:.|..: |||.:.        ||....|:..|:.:::...
  Fly   619 IVIHQYNKVAYDLR-ESAEVVCRVQAYPKPE-FQWQYGNNPSPLTMSSDGHYEISTRMENNDVYT 681

  Fly   551 SRLNYTPSTDLDYGTISCWAKNSIGTQKSPCVFQIVAAGRPFPLQNCSVTNQSVDSLQVDCLEGF 615
            |.|........|||...|.|.|.:.:.::|  .::...|.|....|..:.....:...::...||
  Fly   682 SILRIAHLQHSDYGEYICRAVNPLDSIRAP--IRLQPKGSPEKPTNLKILEVGHNYAVLNWTPGF 744

  Fly   616 DGGLPQGFMLE--LVELNTLRLARNITVS---------------------HTPVTF--------V 649
            :|    |||..  ||....:...|..|:|                     |..:.|        .
  Fly   745 NG----GFMSTKYLVSYRRVATPREQTLSDCSGNGYIPSYQISSSSSNSNHEWIEFNCFKENPCK 805

  Fly   650 IDNLDQAATYRMVIFAVNAKGRSEPTIIDDINFKGVAKFTGASTGLSM---PLSPFLAGLTLFCG 711
            :..|||..:|...::|:|:||.|           |.:....|:|.:|.   ||.......:...|
  Fly   806 LAPLDQHQSYMFKVYALNSKGTS-----------GYSNEILATTKVSKIPPPLHVSYDPNSHVLG 859

  Fly   712 LLFAIFCIMLAAIYRRISNRRSDSNLKVAKHTQLTIPADCQLD-----------PLHPGVQTD-- 763
            :..|..|:.|.|:...:..|.:...:.....|...:|:..:..           |.|....|.
  Fly   860 INVAATCLSLIAVVESLVTRDATVPMWEIVETLTLLPSGSETTFKEAIINHVSRPAHYTTATTSG 924

  Fly   764 -----GSGNHQPHHSLLPLN-------------CDGRNAVDCGAL--GDVG-------------- 794
                 |.|:|......:.|.             |...|...|||.  .::|
  Fly   925 RSLGVGGGSHLGEDRTMALAETAGPGPVVRVKLCLRSNHEHCGAYANAEIGKSYMPHKSSMTTSA 989

  Fly   795 -------------------------------------GGGVGVGLDGGIKGSSPIGLVAMPGDT- 821
                                                 |||||    ||...::     |.||.|
  Fly   990 LVAIIIASLSFVVFLGLLYAFCHCRRKHAAKKESSSVGGGVG----GGNANAT-----ANPGSTG 1045

  Fly   822 -----LRSNARNRHSPMADQADIDDTDPDVIPNQYEKRPLKSLVSPPGFASPSNRLMQRDY---- 877
                 |..:|..|.|...|            |.|.:::|     .||....|:..|..:|.
  Fly  1046 AKEYDLDLDASRRPSLSQD------------PQQSQQQP-----PPPPPYYPTGTLDSKDIGNGN 1093

  Fly   878 ----LRETELTKGGSDVGM-------------------GAAEGLSSIGLMSSSGNEVLH---YTF 916
                |..|.|......:.|                   |...|::..| .::||.:..|   |.:
  Fly  1094 GGMELTLTALHDPDEQLNMQQQQHHSNHGQYQQPKAILGIYGGVAGSG-GNNSGGQHPHSNGYGY 1157

  Fly   917 RPSKQI-----SYATL-----------------------NKKGITTCSPPLGSLNYSVSTST--- 950
            ..:..|     ||..|                       .:.|....:||..:::...|:::
  Fly  1158 HVTSAIGVDSDSYQVLPSVANSAAGSHGHGSGHGHGLGAGESGPLEATPPTCNISGGSSSNSGIN 1222

  Fly   951 PTSSYH-----LTPQPMEVSLLSPNN 971
            |....|     ||.||...:..|.||
  Fly  1223 PMQQQHSARANLTNQPTIATASSTNN 1248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-IV	NP_001034052.2	V-set	79..188	CDD:284989	25/119 (21%)
		IG_like	80..188	CDD:214653	24/116 (21%)
		Ig	210..281	CDD:299845	15/70 (21%)
		Ig	319..392	CDD:299845	23/162 (14%)
		IG_like	319..383	CDD:214653	20/137 (15%)
		IG_like	412..489	CDD:214653	21/97 (22%)
		IGc2	413..478	CDD:197706	19/85 (22%)
		Ig_3	509..572	CDD:290638	18/70 (26%)
		fn3	593..675	CDD:278470	23/112 (21%)
fred	NP_608812.3	Ig	29..126	CDD:299845
		IG_like	141..228	CDD:214653	28/129 (22%)
		Ig	147..228	CDD:299845	26/117 (22%)
		I-set	232..313	CDD:254352	22/106 (21%)
		IGc2	250..302	CDD:197706	16/77 (21%)
		IG_like	323..385	CDD:214653	8/61 (13%)
		IGc2	330..385	CDD:197706	7/54 (13%)
		Ig_2	416..501	CDD:290606	13/84 (15%)
		IG_like	418..501	CDD:214653	12/82 (15%)
		I-set	505..612	CDD:254352	22/111 (20%)
		Ig	526..611	CDD:143165	17/86 (20%)
		IG_like	633..715	CDD:214653	20/84 (24%)
		Ig	635..713	CDD:143165	19/80 (24%)
		FN3	720..838	CDD:238020	26/132 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810