DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side-IV and Mag

DIOPT Version :9

Sequence 1:	NP_001034052.2	Gene:	side-IV / 41657	FlyBaseID:	FBgn0038156	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_058886.1	Gene:	Mag / 29409	RGDID:	3035	Length:	626	Species:	Rattus norvegicus

Alignment Length:	579	Identity:	129/579 - (22%)
Similarity:	220/579 - (37%)	Gaps:	122/579 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 NVESFSEGNDIVLSCEVS-GGRPRPNV---TWYLDN---------------TAIDESFEQRPDGK 253
            ::.:| ||..:.:.|... ....||.|   .||.::               ..:.|||:.|  .:
  Rat    29 SISAF-EGTCVSIPCRFDFPDELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGR--SR 90

  Fly   254 TINHLSYPNVGRQHLNSRLMCVASNTNLTPP-------------NNRVV-----ILDVNLKPIAV 300
            .:..|...|           |....:.|:|.             .|:..     :||:...|
  Rat    91 LLGDLGLRN-----------CTLLLSTLSPELGGKYYFRGDLGGYNQYTFSEHSVLDIINTP--- 141

  Fly   301 HILTKDRFVSADRTYDVECKSSGSKP---PALITWWKGSKQLKKLT--KNFNEPDNQ--SLSILT 358
            :|:.....| |....:|.|....:.|   |.|.  |.|.:.|.:.|  ....|.:..  .:|:|.
  Rat   142 NIVVPPEVV-AGTEVEVSCMVPDNCPELRPELS--WLGHEGLGEPTVLGRLREDEGTWVQVSLLH 203

  Fly   359 FTPGREDDGKYLTCRA-----ENQFIDGSAIEDKWRLIVHYQPTTTLKIGSSLNPDDIKEGDDAY 418
            |.|.||.:|..|.|:|     ..||...::::.|:       |...:::.||:   :..||....
  Rat   204 FVPTREANGHRLGCQAAFPNTTLQFEGYASLDVKY-------PPVIVEMNSSV---EAIEGSHVS 258

  Fly   419 FECIVLANPKPYKMSWFHNGKELQHNISAGVILSDQSLVLQSVSRASAGDYTCLAVNSEGKGPSN 483
            ..|...:||.|. ::|..:|..|:..::..:.|.     |:.|:.|..|.|.|||.|:.|: .:.
  Rat   259 LLCGADSNPPPL-LTWMRDGMVLREAVAESLYLD-----LEEVTPAEDGIYACLAENAYGQ-DNR 316

  Fly   484 PVTLRIRYAPICATDHEELLGALKHETLPLKCEVDSSPPADSFQWTFNSSGEQTELPARLHSSET 548
            .|.|.:.|||...|.:..:: |::.||:.:.|...|:|  |.....|.   |:..|...::.|:.
  Rat   317 TVELSVMYAPWKPTVNGTVV-AVEGETVSILCSTQSNP--DPILTIFK---EKQILATVIYESQL 375

  Fly   549 GMSRLNYTPSTDLDYGTISCWAKNSIGTQKSPCVFQIVAAGRPFPL--QNCSVTNQSVDSLQVDC 611
            .:.....||..|.:|.   |.|:|..|.:.:  .|.:.....|..|  .:|:...   |::|..|
  Rat   376 QLELPAVTPEDDGEYW---CVAENQYGQRAT--AFNLSVEFAPIILLESHCAAAR---DTVQCLC 432

  Fly   612 LEGFDGGLPQGFMLELVELNTLRLARNITVSHTPVTFVIDNLDQAATYRMVIFAVNAKGRSEPTI 676
            :...:......|.|.         :||:||:.|...||..  :::......|..:..:.::.|.:
  Rat   433 VVKSNPEPSVAFELP---------SRNVTVNETEREFVYS--ERSGLLLTSILTLRGQAQAPPRV 486

  Fly   677 I-DDINFKGVAK----FTGASTGLSMPLSPFLAGLTLFCGLLFAIFCIMLAAIYRRISN 730
            | ...|..|...    |.||...:...:.|  .|..:...:|.||.|.:...  ||..|
  Rat   487 ICTSRNLYGTQSLELPFQGAHRLMWAKIGP--VGAVVAFAILIAIVCYITQT--RRKKN 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-IV	NP_001034052.2	V-set	79..188	CDD:284989
		IG_like	80..188	CDD:214653
		Ig	210..281	CDD:299845	16/89 (18%)
		Ig	319..392	CDD:299845	22/84 (26%)
		IG_like	319..383	CDD:214653	21/75 (28%)
		IG_like	412..489	CDD:214653	22/76 (29%)
		IGc2	413..478	CDD:197706	19/64 (30%)
		Ig_3	509..572	CDD:290638	16/62 (26%)
		fn3	593..675	CDD:278470	15/83 (18%)
Mag	NP_058886.1	Interaction with RTN4R and RTN4RL2. /evidence=ECO:0000269\|PubMed:19420245	20..325		73/332 (22%)
		IgV_CD33	22..138	CDD:409377	21/122 (17%)
		Ig strand B	38..42	CDD:409377	0/3 (0%)
		Ig strand C	56..60	CDD:409377	0/3 (0%)
		Ganglioside GT1b binding. /evidence=ECO:0000250\|UniProtKB:P20917	65..67		0/1 (0%)
		Ig strand E	100..104	CDD:409377	1/3 (33%)
		Ig strand F	114..119	CDD:409377	0/4 (0%)
		Ganglioside GT1b binding. /evidence=ECO:0000250\|UniProtKB:P20917	124..128		1/3 (33%)
		Ig strand G	128..133	CDD:409377	0/4 (0%)
		IgC2_CD33_d2_like	141..235	CDD:409579	26/99 (26%)
		Ig strand B	155..159	CDD:409579	1/3 (33%)
		Ig strand C	171..175	CDD:409579	1/5 (20%)
		Ig strand E	200..204	CDD:409579	2/3 (67%)
		Ig strand F	214..219	CDD:409579	2/4 (50%)
		Ig strand G	229..232	CDD:409579	0/2 (0%)
		Ig_3	239..309	CDD:404760	21/78 (27%)
		Ig strand A	239..242	CDD:409353	1/2 (50%)
		Ig strand A'	248..251	CDD:409353	1/5 (20%)
		Ig strand B	256..264	CDD:409353	1/7 (14%)
		Ig strand C	270..274	CDD:409353	0/4 (0%)
		Ig strand C'	277..280	CDD:409353	1/2 (50%)
		Ig strand E	289..293	CDD:409353	1/8 (13%)
		Ig strand F	301..309	CDD:409353	5/7 (71%)
		Ig strand G	312..322	CDD:409353	3/10 (30%)
		IG	333..409	CDD:214652	20/86 (23%)
		Required for normal axon myelination in the central nervous system. /evidence=ECO:0000250\|UniProtKB:P20917	577..626
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	581..608
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000