DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment side-IV and SIGLEC9

DIOPT Version :9

Sequence 1:	NP_001034052.2	Gene:	side-IV / 41657	FlyBaseID:	FBgn0038156	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_006723209.1	Gene:	SIGLEC9 / 27180	HGNCID:	10878	Length:	481	Species:	Homo sapiens

Alignment Length:	370	Identity:	84/370 - (22%)
Similarity:	128/370 - (34%)	Gaps:	87/370 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 LLLPLLMLSGISQVCSTYVEQDELMQNLDRPVPLTTVQGVLGRQAMLPCDISPQER----DDAVY 105
            ||||||.  |..:.      :.:..:.|.....:|..:|:.   ..:||..|....    ...|.
Human     4 LLLPLLW--GRERA------EGQTSKLLTMQSSVTVQEGLC---VHVPCSFSYPSHGWIYPGPVV 57

  Fly   106 MVLWFREG-----DGEPIYNFDVRGRQFGQARLWSSPTAFGTRAHFSSTTHP----AQLKIDNIR 161
            ...|||||     |.....|...|.       :|..     ||..|.....|    ..|.|.:.|
Human    58 HGYWFREGANTDQDAPVATNNPARA-------VWEE-----TRDRFHLLGDPHTKNCTLSIRDAR 110

  Fly   162 IEDEGVYRCRVDFR----NSPTRNLKINLTVIVPPDRPVIYGQNRHEKAGNVESFSEGNDIVLSC 222
            ..|.|.|..|::..    |.....|.:|:|.:.  .||.|.      ..|.:||....|   |:|
Human   111 RSDAGRYFFRMEKGSIKWNYKHHRLSVNVTALT--HRPNIL------IPGTLESGCPQN---LTC 164

  Fly   223 EV----SGGRPRPNVTWYLDNTAIDESFEQRPDGKTINHLSYPNVGRQHLNSRLMCVASNTNLTP 283
            .|    ..|.| |.::|.  .|::............:..:..|    |...:.|.|..:....:.
Human   165 SVPWACEQGTP-PMISWI--GTSVSPLDPSTTRSSVLTLIPQP----QDHGTSLTCQVTFPGASV 222

  Fly   284 PNNRVVILDVNLKP--IAVHILTKDRFVSA------------DRTYDVEC--KSSGSKPPALITW 332
            ..|:.|.|:|:..|  :.:.:...|..||.            .::..:.|  .:..|.|||.::.
Human   223 TTNKTVHLNVSYPPQNLTMTVFQGDGTVSTVLGNGSSLSLPEGQSLRLVCAVDAVDSNPPARLSL 287

  Fly   333 -WKGSKQLKKLTKNFNEPDNQSLSILTFTPGREDDGKYLTCRAEN 376
             |:|      ||...::|.|..:..|.:...|  |....||||:|
Human   288 SWRG------LTLCPSQPSNPGVLELPWVHLR--DAAEFTCRAQN 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-IV	NP_001034052.2	V-set	79..188	CDD:284989	29/125 (23%)
		IG_like	80..188	CDD:214653	28/124 (23%)
		Ig	210..281	CDD:299845	15/74 (20%)
		Ig	319..392	CDD:299845	19/61 (31%)
		IG_like	319..383	CDD:214653	19/61 (31%)
		IG_like	412..489	CDD:214653
		IGc2	413..478	CDD:197706
		Ig_3	509..572	CDD:290638
		fn3	593..675	CDD:278470
SIGLEC9	XP_006723209.1	Ig_Siglec_N	23..140	CDD:143189	30/131 (23%)
		IG_like	26..>118	CDD:214653	24/106 (23%)
		Ig	151..222	CDD:299845	16/80 (20%)
		IG_like	258..336	CDD:214653	19/75 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000