DRSC/TRiP Functional Genomics Resources

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Protein Alignment side-IV and SIGLEC7

DIOPT Version :9

Sequence 1:NP_001034052.2 Gene:side-IV / 41657 FlyBaseID:FBgn0038156 Length:1001 Species:Drosophila melanogaster
Sequence 2:NP_055200.1 Gene:SIGLEC7 / 27036 HGNCID:10876 Length:467 Species:Homo sapiens


Alignment Length:375 Identity:88/375 - (23%)
Similarity:136/375 - (36%) Gaps:98/375 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 LLLPLLMLSGISQVCSTYVEQDELMQNLDRPVPLTTVQGVLGRQAM---LPCDIS----PQERDD 102
            ||||||.  |..:|        |..::..:...||....|..::.|   :.|..|    .|...|
Human     5 LLLPLLW--GRERV--------EGQKSNRKDYSLTMQSSVTVQEGMCVHVRCSFSYPVDSQTDSD 59

  Fly   103 AVYMVLWFREGDGEPIYNFDVRGRQFGQARLWSSPTAFG---------TRAHF----SSTTHPAQ 154
            .|: ..|||.|:       |:.         |.:|.|..         ||..|    ...|....
Human    60 PVH-GYWFRAGN-------DIS---------WKAPVATNNPAWAVQEETRDRFHLLGDPQTKNCT 107

  Fly   155 LKIDNIRIEDEGVYRCRVDFRNSPTR----NLKINLTVIVPPDRPVIYGQNRHEKAGNVESFSEG 215
            |.|.:.|:.|.|.|..|::..|....    .|.:|:|.:.  .||.|.      ..|.:||....
Human   108 LSIRDARMSDAGRYFFRMEKGNIKWNYKYDQLSVNVTALT--HRPNIL------IPGTLESGCFQ 164

  Fly   216 NDIVLSCEV----SGGRPRPNVTWYLDNTAIDESFEQRPDGKTINHLSYPNVGRQHLNSRLMCVA 276
            |   |:|.|    ..|.| |.::|.  .|::............:..:..|    ||..:.|.|..
Human   165 N---LTCSVPWACEQGTP-PMISWM--GTSVSPLHPSTTRSSVLTLIPQP----QHHGTSLTCQV 219

  Fly   277 SNTNLTPPNNRVVILDVNLKP--IAVHILTKDRFVSA------------DRTYDVECKSSGSKPP 327
            :........||.:.|:|:..|  :.|.:...:...|.            .::..:.| :..|.||
Human   220 TLPGAGVTTNRTIQLNVSYPPQNLTVTVFQGEGTASTALGNSSSLSVLEGQSLRLVC-AVDSNPP 283

  Fly   328 ALITW-WKGSKQLKKLTKNFNEPDNQSLSILTFTPGREDDGKYLTCRAEN 376
            |.::| |      :.||...::|.|..:..|....|  |:|:: ||||:|
Human   284 ARLSWTW------RSLTLYPSQPSNPLVLELQVHLG--DEGEF-TCRAQN 324

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
side-IVNP_001034052.2 V-set 79..188 CDD:284989 30/132 (23%)
IG_like 80..188 CDD:214653 29/131 (22%)
Ig 210..281 CDD:299845 16/74 (22%)
Ig 319..392 CDD:299845 20/59 (34%)
IG_like 319..383 CDD:214653 20/59 (34%)
IG_like 412..489 CDD:214653
IGc2 413..478 CDD:197706
Ig_3 509..572 CDD:290638
fn3 593..675 CDD:278470
SIGLEC7NP_055200.1 Ig_Siglec_N 26..144 CDD:143189 31/134 (23%)
Sialic acid binding. /evidence=ECO:0000269|PubMed:12438315, ECO:0000269|PubMed:16623661, ECO:0000269|PubMed:16895906 131..135 0/3 (0%)
Ig 150..223 CDD:325142 19/88 (22%)
IG_like 261..336 CDD:214653 20/74 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 401..431
ITIM motif 435..440
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 443..467
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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