DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side-IV and Siglecg

DIOPT Version :9

Sequence 1:	NP_001034052.2	Gene:	side-IV / 41657	FlyBaseID:	FBgn0038156	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_006540923.1	Gene:	Siglecg / 243958	MGIID:	2443630	Length:	757	Species:	Mus musculus

Alignment Length:	665	Identity:	143/665 - (21%)
Similarity:	226/665 - (33%)	Gaps:	173/665 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 LLLPLL--MLSGISQVCSTYVEQDELMQNLDRPVPLTTVQGVLGRQAMLPCDISPQE----RDDA 103
            |||.||  :|.|......:|..|   :|.:        |:...|....:||..|..|    ....
Mouse     3 LLLFLLSFLLDGPQGQMESYFLQ---VQRI--------VKAQEGLCIFVPCSFSSPEGKWLNRSP 56

  Fly   104 VYMVLWFREGDGEPIYNFDVRGRQFGQARLWSSPTAFGTRAHFSSTTHPAQLKIDNIRIEDEGVY 168
            :| ..||: |..:|..:|.|......:...|.:...|......|...  ..|.|.:::..|...|
Mouse    57 LY-GYWFK-GIRKPSLSFPVATNNKDKVLEWEARGRFQLLGDISKKN--CSLLIKDVQWGDSTNY 117

  Fly   169 RCRVD--FRNSPTRNLKINLTVIVPPDRPVIYGQNRHEKAGNVESFSEGNDIVLSCEVS---GGR 228
            ..|::  |.....:. :..|.|.....:|.|:         ..|....|..:.:.|..|   ...
Mouse   118 FFRMERGFERFSFKE-EFRLQVEALTQKPDIF---------IPEVLEPGEPVTVVCLFSWTFNQC 172

  Fly   229 PRPNVTWYLDNTAIDESFEQRPDGKTINHLSY-PNVGRQHLNSRLMCVASNTNLTPPNNRVVILD 292
            |.|:.:|..|..:..||   ||.....:.||: |  |.||.::.|.|....:.::  ..|.|.|.
Mouse   173 PAPSFSWMGDAVSFQES---RPHTSNYSVLSFIP--GLQHHDTELTCQLDFSRMS--TQRTVRLR 230

  Fly   293 VNLKP--IAVHILTKDRF-------------VSADRTYDVECKSSGSKPPALITWWKGSKQLKKL 342
            |...|  :|:.|. .|..             |...::..:.| ::.|:|||.::|     .|:..
Mouse   231 VAYAPRSLAISIF-HDNVSVPDLHENPSHLEVQQGQSLRLLC-TADSQPPATLSW-----VLEDQ 288

  Fly   343 TKNFNEPDNQSLSILTFTPGREDDGKYLTCRAENQFIDGSAIEDKWRLIVHYQPTTTLKIGSSLN 407
            ..:::.|.......|.....:..|..:.||:|||                        ::||..:
Mouse   289 VLSWSSPVGSRTLALELPWVKAGDSGHYTCQAEN------------------------RLGSQQH 329

  Fly   408 PDDIKEGDDAYFECIVLAN------PKPYKMSWFHNGKELQHNISAGVILSDQSLVLQSVSRASA 466
            ..|:.          ||..      |.|.|.....:|.: |.:..|..:....|.........|.
Mouse   330 TLDLS----------VLCEYDLPKVPGPKKDKGVTSGYK-QSDYCAACVGDPMSDAPTHPQLPSL 383

  Fly   467 GDYTCLAVNSEGKGP------------SNPVTLRIRYAPICATDHEEL-----LGALKHETLPLK 514
            |...|     .|:.|            ..|..||:..:....|..|.|     |..|:.::|.|.
Mouse   384 GGMFC-----PGRRPWPVWSQFPVFIADPPQDLRVTVSQANRTVLEILRNAISLPVLEGQSLCLV 443

  Fly   515 CEVDSSPPAD-SFQWTFNSSGEQTELPARLHSSETGMSRLNYTPSTDLDY-GTISCWAKNSIGTQ 577
            |...|:|||: |:.|.     .||.:|  :.|||.|:..|   |....:: |..:|.|:|.:|.|
Mouse   444 CVTYSNPPANVSWAWV-----TQTLIP--IQSSEPGVLEL---PLVQREHEGEFTCAAQNPLGAQ 498

  Fly   578 KSPCVFQIVAAGRPFPLQ---------------NCSVTNQSVDSLQVDCLEGFDGGLPQGFMLEL 627
            :......:     .:|.|               |||.......||:....||            |
Mouse   499 RISLSLSV-----HYPPQMSSPSCSWEAKGLHCNCSSRAWPAPSLRWRLGEG------------L 546

  Fly   628 VELNTLRLARNITVS 642
            :|.|:...:..:|.|
Mouse   547 LEGNSSNASFTVTFS 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-IV	NP_001034052.2	V-set	79..188	CDD:284989	23/114 (20%)
		IG_like	80..188	CDD:214653	23/113 (20%)
		Ig	210..281	CDD:299845	20/74 (27%)
		Ig	319..392	CDD:299845	15/72 (21%)
		IG_like	319..383	CDD:214653	15/63 (24%)
		IG_like	412..489	CDD:214653	16/94 (17%)
		IGc2	413..478	CDD:197706	12/70 (17%)
		Ig_3	509..572	CDD:290638	21/64 (33%)
		fn3	593..675	CDD:278470	14/65 (22%)
Siglecg	XP_006540923.1	Ig	22..132	CDD:386229	25/124 (20%)
		Ig	145..216	CDD:386229	22/84 (26%)
		Ig	256..335	CDD:386229	19/118 (16%)
		IG	431..506	CDD:214652	26/84 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000