DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side-IV and Siglecf

DIOPT Version :9

Sequence 1:	NP_001034052.2	Gene:	side-IV / 41657	FlyBaseID:	FBgn0038156	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_036008858.1	Gene:	Siglecf / 233186	MGIID:	2681107	Length:	589	Species:	Mus musculus

Alignment Length:	826	Identity:	154/826 - (18%)
Similarity:	227/826 - (27%)	Gaps:	361/826 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 WFREG----DGEPIYNFD--------VRGRQFGQARLWSSPTAFGTRAHFSSTTHPAQLKIDNIR 161
            |||||    .|.|:...|        .:||.:...:               ..:|...|.|.:.:
Mouse    75 WFREGANIFSGSPVATNDPQRSVLKEAQGRFYLMGK---------------ENSHNCSLDIRDAQ 124

  Fly   162 IEDEGVYRCRVD------FRNSPTRNLKINLTVIVPPDRPVIYGQNRHEKAGNVESFSEGNDIVL 220
            ..|.|.|..|:|      |:.|....|.|.||.:  |:..|            ..:...||...|
Mouse   125 KIDTGTYFFRLDGSVKYSFQKSMLSVLVIALTEV--PNIQV------------TSTLVSGNSTKL 175

  Fly   221 SCEV----SGGRPRPNVTWYLDNTAIDESFEQRPDGKTINHLSYPNVGRQHLNSRLMCVASNTNL 281
            .|.|    ..|.| |..:|                                ::|.|..:...|.|
Mouse   176 LCSVPWACEQGTP-PIFSW--------------------------------MSSALTSLGHRTTL 207

  Fly   282 TPPNNRVVILDVNLKPIAVHILTKDRFVSADRTYDVECKSSGSKPPALITWWKGSKQLKKLTKNF 346
            :
Mouse   208 S---------------------------------------------------------------- 208

  Fly   347 NEPDNQSLSILTFTPGREDDGKYLTCRAENQFIDGSAIEDKWRLIVHYQP--------------T 397
                    |.|..||..:|:|..|||:. |....|..:|...:|.|.|.|              |
Mouse   209 --------SELNLTPRPQDNGTNLTCQV-NLPGTGVTVERTQQLSVIYAPQKMTIRVSWGDDTGT 264

  Fly   398 TTLKIGSSLNPDDIKEGDDAYFECIVLANPKPYKMSWFH-NGKELQHNISAGVILSDQSLVLQSV 461
            ..|:.|:||   .|:||:.....|:..:|| |..:||.. ..|..|.:..|       .|.|...
Mouse   265 KVLQSGASL---QIQEGESLSLVCMADSNP-PAVLSWERPTQKPFQLSTPA-------ELQLPRA 318

  Fly   462 SRASAGDYTCLAVNSEGKGPSNPVTLRIRYAPICATDHEELLG-ALKHETLPLKCEVDSSP-PAD 524
            .....|.|.|.|.||:|...:: |:|.||       ...:||| :...|...|.|...|.. ||.
Mouse   319 ELEDQGKYICQAQNSQGAQTAS-VSLSIR-------SLLQLLGPSCSFEGQGLHCSCSSRAWPAP 375

  Fly   525 SFQWTF--------NSSGEQTELPARLHSSETGMSRLNYTPSTDLDYGTISCWAKNSIGTQKSPC 581
            |.:|..        :|:|..|     :.||..|.                  ||.:|:
Mouse   376 SLRWRLGEGVLEGNSSNGSFT-----VKSSSAGQ------------------WANSSL------- 410

  Fly   582 VFQIVAAGRPFPLQNCSVTNQSVDSLQVDCLEGFDGGLPQGFMLELVELNTLRLARNITVSHTPV 646
                                                            :.::..:.|..:|....
Mouse   411 ------------------------------------------------ILSMEFSSNHRLSCEAW 427

  Fly   647 TFVIDNLDQAATYRMVIF-AVNAKGRSEPTIIDDINFKGVAKFTGASTGLSMPLSPFLAGLTLFC 710
            :   ||..|.||..:|.. .|:..|:||.:       :|..  .||..|         ||
Mouse   428 S---DNRVQRATILLVSGPKVSQAGKSETS-------RGTV--LGAIWG---------AG----- 466

  Fly   711 GLLFAIFCIMLAAIYRRISNRRSDSNLKVAKHTQLTIPADCQLDPLHPGVQTDGSGNHQPHHSLL 775
              |.|:..:.|..|:..:...|..|.||||.                      ..|||...:...
Mouse   467 --LMALLAVCLCLIFFTVKVLRKKSALKVAA----------------------TKGNHLAKNPAS 507

  Fly   776 PLNCDGRNAVDCGALGDVGGGGVGVGLDGGIKGSSPI-GLVAMPGDTLRSNARNRHSPMADQADI 839
            .:|.           ..:....:.:|.        || |.:..||    |..:....|:|...|.
Mouse   508 TINS-----------ASITSSNIALGY--------PIQGHLNEPG----SQTQKEQPPLATVPDT 549

  Fly   840 DDTDPDVIPNQYEKRPLKSLVSPPGFASPSNRLMQRDYLRETELTK 885
            ...:|::   .|.....:..:.|    .|.|....:....|.::.|
Mouse   550 QKDEPEL---HYASLSFQGPMPP----KPQNTEAMKSVYTEIKIHK 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-IV	NP_001034052.2	V-set	79..188	CDD:284989	23/96 (24%)
		IG_like	80..188	CDD:214653	23/96 (24%)
		Ig	210..281	CDD:299845	12/74 (16%)
		Ig	319..392	CDD:299845	13/72 (18%)
		IG_like	319..383	CDD:214653	11/63 (17%)
		IG_like	412..489	CDD:214653	22/77 (29%)
		IGc2	413..478	CDD:197706	19/65 (29%)
		Ig_3	509..572	CDD:290638	16/71 (23%)
		fn3	593..675	CDD:278470	12/82 (15%)
Siglecf	XP_036008858.1	Ig	40..153	CDD:416386	21/92 (23%)
		FR1	40..64	CDD:409353
		Ig strand A	40..44	CDD:409353
		Ig strand A'	47..51	CDD:409353
		Ig strand B	53..64	CDD:409353
		CDR1	65..70	CDD:409353
		FR2	71..78	CDD:409353	2/2 (100%)
		Ig strand C	71..78	CDD:409353	2/2 (100%)
		CDR2	79..102	CDD:409353	4/22 (18%)
		Ig strand C'	89..92	CDD:409353	0/2 (0%)
		FR3	103..136	CDD:409353	9/47 (19%)
		Ig strand D	104..108	CDD:409353	1/3 (33%)
		Ig strand E	114..122	CDD:409353	3/7 (43%)
		Ig strand F	129..136	CDD:409353	3/6 (50%)
		FR4	140..153	CDD:409353	3/12 (25%)
		Ig strand G	140..153	CDD:409353	3/12 (25%)
		Ig	159..243	CDD:416386	27/201 (13%)
		Ig strand A	159..163	CDD:409353	1/3 (33%)
		Ig strand B	172..178	CDD:409353	1/5 (20%)
		Ig strand C	190..195	CDD:409353	1/36 (3%)
		Ig strand E	209..215	CDD:409353	2/5 (40%)
		Ig strand F	222..229	CDD:409353	3/7 (43%)
		Ig strand G	236..243	CDD:409353	1/6 (17%)
		IG	272..345	CDD:214652	25/84 (30%)
		Ig	357..427	CDD:416386	19/147 (13%)
		Ig strand B	363..370	CDD:409353	2/6 (33%)
		Ig strand C	376..381	CDD:409353	2/4 (50%)
		Ig strand C'	383..386	CDD:409353	0/2 (0%)
		Ig strand D	395..402	CDD:409353	3/11 (27%)
		Ig strand E	405..412	CDD:409353	3/61 (5%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000