DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side-IV and igcm-1

DIOPT Version :9

Sequence 1:	NP_001034052.2	Gene:	side-IV / 41657	FlyBaseID:	FBgn0038156	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_508166.1	Gene:	igcm-1 / 180433	WormBaseID:	WBGene00018215	Length:	1073	Species:	Caenorhabditis elegans

Alignment Length:	1120	Identity:	225/1120 - (20%)
Similarity:	342/1120 - (30%)	Gaps:	438/1120 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 MLPCDISPQERDDAVYMVLWFREGDGEPIYNFDVRGRQFGQARLWSSPTAFGTRAHF------SS 148
            ::||.:.|:..|...|.:.|.|       ||       .||.|:.:.......:.|.      .|
Worm    46 VIPCVVKPEYFDRQKYEINWAR-------YN-------NGQLRMITKNDKLLAKKHSRFILENDS 96

  Fly   149 TTHPAQLKIDNIRIED-EGVYRCRV------DFRNSPTRNLKINLTVIVPPDRPVIYGQNRHEKA 206
            .|....|:|..:.... ||.|.|.|      |.:.|..    ..:.|:|||..|:|       ..
Worm    97 ATGNYSLRITEVEKNSVEGTYHCNVIGTDDSDVQYSAL----ATVVVLVPPGDPII-------ST 150

  Fly   207 GNVESFSEGNDIVLSCEVSGGRPRPNVTWYLDNTAIDES-------------------FEQRPDG 252
            ...||..||:.:...|...||.|:|..||.|.|..|..|                   .....||
Worm   151 TPSESVIEGDFMTAKCVSVGGSPQPTFTWTLPNDTIASSAIFTTQFRDGATESLLHFRVTSSDDG 215

  Fly   253 KTI--------------------------------------NHLSY------------------- 260
            |::                                      .|||.
Worm   216 KSVQCDVTNRAMLGGETKQVKSSQLNVLYKPVVFVTPTENLTHLSVEEGELVNLTCNSASNPPAH 280

  Fly   261 ----------------------------------------------------------------- 260

Worm   281 SYEWKHIASGERYQGKIWPIRVDSSMSGDFECRSTNELGEGTAVLKMVVQHIPRINVPESISPNE 345

  Fly   261 -----------------------PNVGRQHLNSRL-------------MCVASN----------- 278
                                   ||..:|: .|||             .|:|:|
Worm   346 MEDIDILCEVSAVPEVIDIKWVGPNGFKQN-GSRLTITSISKAQSGNYTCMATNFLTVYGHSGSQ 409

  Fly   279 ----TNLTPPNNRVVILDVNLKPIAVHILTKDRFVSADRTYDVECKS-SGSKPPALITWWKGSK- 337
                |..|       |:||..||....|::..:.|....|..:.|:: ....|.|..||...|.
Worm   410 QRMGTGTT-------IVDVKRKPGQAQIVSARQNVDVGETIKLMCQAEDAGNPSASYTWASPSSG 467

  Fly   338 ---QLKKLTKNFNEPDNQSLSILTFTPGREDDGKYLTCRAENQFIDGS------AIEDKWRLIVH 393
               .|:..|:...|..|..||         |:|.| :|:|.|...:|.      .:.:|.|:
Worm   468 GIFGLEGHTEKSFEVRNAQLS---------DNGVY-SCKAYNDLGEGKIGTVMITVIEKARI--- 519

  Fly   394 YQPTTTLKIGSSLNPDDIKEGDDAYFECIVLANPKPYKMSWFHNGKELQHNISAGVILSD----- 453
            ..|..|.:|.:|.....|       .||.....|.|. :.|..:|:.::.:|.|....|:
Worm   520 SSPLATERIFTSGEQGKI-------LECEAQGYPSPV-IKWLKDGRPVKQSIYASSATSESKCLP 576

  Fly   454 QSLVLQSVSR----------ASAGDYTCLAVNSE---GKGPSNPVTLRIRYAPICAT---DHEEL 502
            :....|:|:.          :..|::||:|.|..   .|..|:...:|:.:.|:...   ..:.|
Worm   577 EDFCTQTVASTLTLAGPLKWSDKGNFTCVADNGSDKTDKDSSSWTIVRVLHKPVFLNRKFPEKSL 641

  Fly   503 LGALKHETLPLKCEVDSSPPADSFQWTFNSSGEQTELPARLHSSET-GMS--------RLNYTPS 558
            ..|.......::|:| |:.|...|.|.|..| |.:|  ...||..| |::        .|.....
Worm   642 AAADIGSQAIIRCKV-SARPEPEFHWMFRDS-EISE--NERHSFHTVGITGKPDEYEQLLQIESV 702

  Fly   559 TDLDYGTISCWAKNSIG--------TQKSPCVFQIVAAGRPFPLQNCSVTNQSVDSLQVDCLEGF 615
            .:.|||...|.|.|..|        .:.||       ...|..||..|.|:.||   .:..:..|
Worm   703 QESDYGEYVCRATNGNGGDHVVIELRKTSP-------PALPLDLQKLSATSNSV---LLGWVPQF 757

  Fly   616 DGGLPQGFMLE----------------LVELNTLRLARNITVSHTPVT---FVIDNLDQAATYRM 661
            |||..|.::||                :.:||...:.::..:..|.|:   |....|...:||.:
Worm   758 DGGADQTYVLETRKIDPFTGEIDGNAPVSKLNINAVQQDQEIDGTLVSKNIFNFTGLTPLSTYNL 822

  Fly   662 VIFAVNAKGRSEPT---------IIDDINFKGVAKFTGASTGLSMPLSPFLAGLTLFCGLLFAIF 717
            .|.||:.||.||.|         :::|.|....::....|:...:.:.|.|....  |.||:
Worm   823 RIQAVSEKGESEFTPVLIASTEDVVEDANMMSPSRLVLDSSEQKINVEPKLPSDA--CTLLY--- 882

  Fly   718 CIMLAAIYRRISNRRSDSNLKVAKHTQLTIPADCQLDPLHPGVQTDGSGNHQPHHSLLPLNCDGR 782
             :.|..|: |.|...:.||                  |:         ||..|........|...
Worm   883 -VFLDGIW-RTSTCHTSSN------------------PI---------GNIIPGREYRARFCTTA 918

  Fly   783 NAVDCGALGDVGGGGVG----------------VGL------------DGGIKGS--SPIGLVAM 817
            |.:.|..:......|.|                :||            ....|.|  |||.|.::
Worm   919 NGLKCSPVSKTISSGSGSVWKTNVFFPFLFFIFIGLAICVFFLVCCKTRSNPKTSKLSPIILTSL 983

  Fly   818 PGDTLRSNA---RNRHSPMADQADIDDTDPDVIPNQYEKRPLKSLVSPPGFASPSNRLMQRD--- 876
            |||.|:..|   ..:|:..|    |.:.:.:.: :|::.:..|    |||..      |:.|
Worm   984 PGDELKRPADYEEPKHATFA----ITENETNHL-SQHDAKSTK----PPGLN------MEYDVST 1033

  Fly   877 --YLRE-TELTKGGS 888
              ||:| ||:.|..|
Worm  1034 DCYLQENTEVLKNTS 1048

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-IV	NP_001034052.2	V-set	79..188	CDD:284989	24/110 (22%)
		IG_like	80..188	CDD:214653	24/110 (22%)
		Ig	210..281	CDD:299845	31/262 (12%)
		Ig	319..392	CDD:299845	21/83 (25%)
		IG_like	319..383	CDD:214653	19/74 (26%)
		IG_like	412..489	CDD:214653	18/94 (19%)
		IGc2	413..478	CDD:197706	16/82 (20%)
		Ig_3	509..572	CDD:290638	20/71 (28%)
		fn3	593..675	CDD:278470	28/100 (28%)
igcm-1	NP_508166.1	Ig	45..119	CDD:299845	20/86 (23%)
		Ig	146..226	CDD:299845	20/86 (23%)
		Ig_3	245..316	CDD:290638	3/70 (4%)
		IG_like	258..329	CDD:214653	3/70 (4%)
		IG_like	338..398	CDD:214653	8/60 (13%)
		IGc2	347..398	CDD:197706	8/51 (16%)
		Ig_2	429..513	CDD:290606	22/93 (24%)
		IG_like	437..513	CDD:214653	21/85 (25%)
		Ig	537..615	CDD:143165	17/85 (20%)
		IG_like	644..728	CDD:214653	23/87 (26%)
		IGc2	646..719	CDD:197706	21/76 (28%)
		FN3	733..843	CDD:238020	30/112 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810