DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment side-IV and Mag

DIOPT Version :9

Sequence 1:	NP_001034052.2	Gene:	side-IV / 41657	FlyBaseID:	FBgn0038156	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001333013.1	Gene:	Mag / 17136	MGIID:	96912	Length:	627	Species:	Mus musculus

Alignment Length:	568	Identity:	132/568 - (23%)
Similarity:	201/568 - (35%)	Gaps:	153/568 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 TTVQGVLGRQAMLPCDIS-PQERDDAVYMVLWFREGDGEPIY--------------NFDVRGRQF 128
            :|:....|....:||... |.|...||...:|:........|              :|..|.|..
Mouse    28 STISAFEGTCVSIPCRFDFPDELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLL 92

  Fly   129 GQARLWS--------SPTAFGTRAHFSSTTHPAQLKIDNIRIEDEGVY-------RCRVDFRNSP 178
            |...|.:        || ..|.:.:|..               |.|.|       ...:|..|:|
Mouse    93 GDLGLRNCTLLLSTLSP-ELGGKYYFRG---------------DLGGYNQYTFSEHSVLDIVNTP 141

  Fly   179 TRNLKINLTVIVPPDRPVIYGQNRHEKAGNVESFSEGNDIVLSCEVSGGRP--RPNVTWYLDNTA 241
                    .::|||:  |:                .|.::.:||.|....|  ||.::| |.:..
Mouse   142 --------NIVVPPE--VV----------------AGTEVEVSCMVPDNCPELRPELSW-LGHEG 179

  Fly   242 IDESF---EQRPDGKTINHLS----YPNVGRQHLNSRLMCVASNTNLTPPNNRVVILDVNLKPIA 299
            :.|..   ..|.|..|...:|    .|.  |:....||.|.|:..|.|........|||...|:.
Mouse   180 LGEPTVLGRLREDEGTWVQVSLLHFVPT--REANGHRLGCQAAFPNTTLQFEGYASLDVKYPPVI 242

  Fly   300 VHILTKDRFVSADRTYDVECKSSGSKPPALITWWKGSKQLKKLTKNFNEPDNQSLSILTFTPGRE 364
            |.:.:....:..... .:.| .:.|.||.|:||.:....|::....     :..|.:...|||
Mouse   243 VEMNSSVEAIEGSHV-SLLC-GADSNPPPLLTWMRDGMVLREAVAK-----SLYLDLEEVTPG-- 298

  Fly   365 DDGKYLTCRAENQF-IDGSAIEDKWRLIVHYQPTTTLKIGSSLNPDDIKEGDDAYFECIVLANPK 428
            :||.| .|.|||.: .|...:|    |.|.|.|......|:.:    ..||:.....|...:||.
Mouse   299 EDGVY-ACLAENAYGQDNRTVE----LSVMYAPWKPTVNGTVV----AVEGETVSILCSTQSNPD 354

  Fly   429 PYKMSWFHNGKELQHNISAGVILSDQ-SLVLQSVSRASAGDYTCLAVNSEGKGPSNPVTLRIRYA 492
            |. ::.|   ||.|  |.|.||...| .|.|.:|:....|:|.|:|.|..|: .:....|.:.:|
Mouse   355 PI-LTIF---KEKQ--ILATVIYESQLQLELPAVTPEDDGEYWCVAENQYGQ-RATAFNLSVEFA 412

  Fly   493 PICATDHEELLGALKHETLPLKCEVDSSP-PADSFQWTFNSSGEQTELPAR-----------LHS 545
            ||...:..   .|...:|:...|.|.|:| |:.:|           |||:|           ::|
Mouse   413 PIILLESH---CAAARDTVQCLCVVKSNPEPSVAF-----------ELPSRNVTVNETEREFVYS 463

  Fly   546 SETGM---------SRLNYTPSTDLDYGTISCWAKNSIGTQKSPCVFQ 584
            ..:|:         .:....|       .:.|.::|..|||.....||
Mouse   464 ERSGLLLTSILTIRGQAQAPP-------RVICTSRNLYGTQSLELPFQ 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-IV	NP_001034052.2	V-set	79..188	CDD:284989	25/138 (18%)
		IG_like	80..188	CDD:214653	25/137 (18%)
		Ig	210..281	CDD:299845	20/79 (25%)
		Ig	319..392	CDD:299845	22/73 (30%)
		IG_like	319..383	CDD:214653	20/64 (31%)
		IG_like	412..489	CDD:214653	25/77 (32%)
		IGc2	413..478	CDD:197706	23/65 (35%)
		Ig_3	509..572	CDD:290638	15/83 (18%)
		fn3	593..675	CDD:278470
Mag	NP_001333013.1	Interaction with RTN4R and RTN4RL2. /evidence=ECO:0000250\|UniProtKB:P07722	20..325		79/355 (22%)
		IgV_CD33	22..137	CDD:409377	22/124 (18%)
		Ig strand B	38..42	CDD:409377	0/3 (0%)
		Ig strand C	56..60	CDD:409377	0/3 (0%)
		Ganglioside GT1b binding. /evidence=ECO:0000269\|PubMed:27922006	65..67		0/1 (0%)
		Ig strand E	100..104	CDD:409377	0/3 (0%)
		Ig strand F	114..119	CDD:409377	1/4 (25%)
		Ganglioside GT1b binding. /evidence=ECO:0000269\|PubMed:27922006	124..128		1/3 (33%)
		Ig strand G	128..133	CDD:409377	0/4 (0%)
		IgC2_CD33_d2_like	141..235	CDD:409579	27/122 (22%)
		Ig strand B	155..159	CDD:409579	0/3 (0%)
		Ig strand C	171..175	CDD:409579	1/4 (25%)
		Ig strand E	200..204	CDD:409579	1/3 (33%)
		Ig strand F	214..219	CDD:409579	3/4 (75%)
		Ig strand G	229..232	CDD:409579	0/2 (0%)
		Ig_3	239..309	CDD:404760	19/79 (24%)
		Ig strand A	239..242	CDD:409353	1/2 (50%)
		Ig strand A'	248..251	CDD:409353	0/2 (0%)
		Ig strand B	256..264	CDD:409353	1/9 (11%)
		Ig strand C	270..274	CDD:409353	2/3 (67%)
		Ig strand C'	277..280	CDD:409353	0/2 (0%)
		Ig strand E	289..293	CDD:409353	1/3 (33%)
		Ig strand F	301..309	CDD:409353	4/8 (50%)
		Ig strand G	312..322	CDD:409353	3/13 (23%)
		IG	333..409	CDD:214652	26/86 (30%)
		Required for normal axon myelination in the central nervous system. /evidence=ECO:0000269\|PubMed:9482783	578..627
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000