DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment side-IV and si:ch211-180a12.2

DIOPT Version :9

Sequence 1:	NP_001034052.2	Gene:	side-IV / 41657	FlyBaseID:	FBgn0038156	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_001920945.3	Gene:	si:ch211-180a12.2 / 100150385	ZFINID:	ZDB-GENE-121214-236	Length:	903	Species:	Danio rerio

Alignment Length:	783	Identity:	154/783 - (19%)
Similarity:	271/783 - (34%)	Gaps:	198/783 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 KAG-NVE-SFSEGNDIVLSCEVSGGRPRP--------NVTWYLDNTAIDESFEQRPDGKTINHLS 259
            ||| :|: |.|.|:..||:|..:    .|        |:||....:.| .|......|..:|..:
Zfish    16 KAGSSVDVSVSPGSSTVLNCSFA----LPALVDNSLLNITWSSGGSII-ASKNHTQAGFFLNSTA 75

  Fly   260 YPNVGRQHLNSRLMCVASNTNLTPPNNRV---------------VILDVNLKPIAVHILTKDRFV 309
            :|:......|:           ||....|               |.|.: |.|..|.|::.:..:
Zfish    76 FPSFPLTVFNA-----------TPHQQGVYECRVSYNDTDYATEVTLTI-LAPPVVSIISPEAVL 128

  Fly   310 SADRTYDVECKSSGSKPPALI-TWWKGSKQL---KKLTKNFNEPD-NQSLSILTFTPGREDDGKY 369
            .  |...|||.:....||.:: ||.:|..::   :||..|..|.. ..::|.|||.|...:....
Zfish   129 K--RKSVVECWARSFSPPQIMFTWTRGGNKIQEPQKLQVNRTEDGLYDAVSFLTFIPQISNQNIS 191

  Fly   370 LTCRAENQFIDGSAIEDKWRLIVHYQPTTTL--KIGSSLNPDDIKEGDDAYFECIVLA-NPKPYK 431
            ..|..::..:....:|:       :.|..|:  |:..|:.|.. .........|.:.. .|....
Zfish   192 FGCEVQHSALVKPVLEE-------FTPHITVLPKVTLSVVPSS-SHSSSVTLSCDISGFYPNNIS 248

  Fly   432 MSWFHNGKELQH-----NISAGVILSDQSLVLQSVSRASAGDYTCLAVNSEGKGPSNPVTLRIRY 491
            :.|.||||:|..     ....|.....|...|....|:..|:..|:|:...|:.|:|
Zfish   249 VLWIHNGKKLSELPLSIQNEDGTYRRHQYHTLTREERSRGGEVQCVALQPSGQEPAN-------- 305

  Fly   492 APICATDHEELLGALKHETLPLKCE---VDSSPPAD----------------SFQW--------T 529
                        |.:...|:.|:.:   ::.|..|.                .|.|        :
Zfish   306 ------------GTIDLSTVDLRVQNPGLNKSAKASVAMMIISLTLVFLLCFGFSWKRRDEKLKS 358

  Fly   530 FNSSGEQTELPARLHSSETGMSRLNYTPSTDLDYGTISCWAKNSIGTQKSPCVFQIVAAGR--PF 592
            .|.|.  ..||.|:...:.|  |:..:....|.....:.|..|.|..:.:....:...|.|  .:
Zfish   359 LNISA--IVLPPRVVVGKKG--RVTISVEGRLAERVQTTWFLNDIPIKDTSHKEKKYGAFRSASY 419

  Fly   593 PLQNCSVTNQSVDSLQVDCLEGFDGGLPQGFMLELVELNT---LRLARNITVS-HTPVTFVIDNL 653
            ..:|.||   ||.|.:...|.....|        ..:|:|   ||.:.|.:.. .:.|||:
Zfish   420 TSRNSSV---SVLSEKNPLLPSSASG--------YYKLHTQMPLRSSSNSSKQLFSSVTFI---- 469

  Fly   654 DQAATYRMVIF--AVNAKGRSE--------------PTIIDDINFK------GVAKFTGASTGLS 696
            ...|.::..:|  .|:.||:.:              |..:.:|.|.      ||...|..::...
Zfish   470 PSLAVHKGSVFKCQVSYKGKDKIVAERVSEKFTILAPPEVSEIQFSEPNEEGGVVTMTAHASHFH 534

  Fly   697 MPLSPFLAGLTLFCGLLFAIFC----IMLAAIYRRISNRRSDSNLKVAKHTQLTIP-ADCQLDPL 756
            ..:            :.|..||    :...:|.:.::..|.|:....:..:|..:| |:.:....
Zfish   535 PDI------------ITFRWFCEGGELSPVSIPQALAAPRPDAEGFFSAMSQCRLPKAELERGET 587

  Fly   757 HPGVQTDGSGNHQPHHSLL--PLNCDGRNAVDCGALGDVGGGGVGVGLDGGIKGSSPIGLVAMPG 819
            ...|..        ||:.|  |:....|..:...::.::....|...|:|.:..:..|.....|
Zfish   588 RVWVTI--------HHTALKQPITRQTRGFIKQPSISEILSCPVASVLEGRLTLACEITGFYPP- 643

  Fly   820 DTLRSNARNRHSPMADQADIDDTDPDVIPNQYEKRPLKSLVSPPGFASPSNRLMQRDYLRETELT 884
               ..:.:..||...:..|.||::.::........||::|  |..|.:   :.:.:|.   .|:|
Zfish   644 ---EISVKWLHSKGNEIEDGDDSEEEIKDGAEVWGPLQTL--PRTFRA---KALLKDV---NEMT 697

  Fly   885 KGG 887
            :||
Zfish   698 RGG 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-IV	NP_001034052.2	V-set	79..188	CDD:284989
		IG_like	80..188	CDD:214653
		Ig	210..281	CDD:299845	16/79 (20%)
		Ig	319..392	CDD:299845	17/77 (22%)
		IG_like	319..383	CDD:214653	16/68 (24%)
		IG_like	412..489	CDD:214653	18/82 (22%)
		IGc2	413..478	CDD:197706	15/70 (21%)
		Ig_3	509..572	CDD:290638	15/89 (17%)
		fn3	593..675	CDD:278470	21/101 (21%)
si:ch211-180a12.2	XP_001920945.3	Ig	19..114	CDD:299845	22/111 (20%)
		IG_like	22..113	CDD:214653	21/106 (20%)
		C1-set	123..205	CDD:284964	19/83 (23%)
		IgC	237..309	CDD:143166	19/91 (21%)
		IgC	515..604	CDD:143166	17/108 (16%)
		IgC	609..720	CDD:143166	20/104 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900