DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yrt and HPF1

DIOPT Version :9

Sequence 1:	NP_650291.1	Gene:	yrt / 41656	FlyBaseID:	FBgn0004049	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	NP_014487.1	Gene:	HPF1 / 854010	SGDID:	S000005515	Length:	967	Species:	Saccharomyces cerevisiae

Alignment Length:	552	Identity:	114/552 - (20%)
Similarity:	187/552 - (33%)	Gaps:	174/552 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   493 SGSISSSSQAAANFASLGRNSLKSNFSNEDPAYSKIGSIGKASGLTVKLDPDYTPPYSPNATKNF 557
            |.||:|:|..|.:..|.|..|:.|:............|:.:.:..:.::.....|..|.:...:
Yeast    29 SSSIASNSSTAVSSTSSGSVSISSSIELTSSTSDVSSSLTELTSSSTEVSSSIAPSTSSSEVSS- 92

  Fly   558 DETNPFRNATSSHHGSFGKASISSGQLSVKSGLSDKDRELDSLLKSIVKDPSPSVLANEAINDAN 622
                   :.|||.....|.:||:|...||.|.            .|..:..|.:..::.|....:
Yeast    93 -------SITSSGSSVSGSSSITSSGSSVSSS------------SSATESGSSASGSSSATESGS 138

  Fly   623 SIRVTINKTFDMDHNTETLKRLSNANEKPNNQVKLANVNTTALPPGNIKCNILKARVEEELGAGG 687
            |:         ...:|......|:|.|..::    .:.:|:|...|:              .|.|
Yeast   139 SV---------SGSSTSITSGSSSATESGSS----VSGSTSATESGS--------------SASG 176

  Fly   688 NAKLTNQMFVPAAHSSNMHTSNTNSSNNHAHSDGPDSLNATYISVGGDKLTLSIPEQKPSTGSSS 752
            ::..|......:..||...:.::.|.::.|...|.....::..:..|.  ..|:|....|...|.
Yeast   177 SSSATESGSSASGSSSATESGSSVSGSSSATESGSSVSGSSSATESGS--ASSVPSSSGSVTESG 239

  Fly   753 SSSTSSTATTTTNGNGPYSNA-----------TFVSGFSAPLTP--PSSLPANLN--NTGSGCNT 802
            |||::|.::.|.:|....|:|           :.|||.||...|  .||:|.:.:  :|.||..|
Yeast   240 SSSSASESSITQSGTASGSSASSTSGSVTQSGSSVSGSSASSAPGISSSIPQSTSSASTASGSIT 304

  Fly   803 --TLTSVTTISTPSSPTATVSTTASES----------------------VAPALSNASAAEILIN 843
              ||:|:|  |:.||.|||.|.:.|.|                      ...|:..|:..::.:.
Yeast   305 SGTLSSIT--SSASSATATASNSLSSSDGTIYLPSTTISGDITLTGSVIATEAVEVAAGGKLTLL 367

  Fly   844 E----IFINNII------------------------NNNASGSITAETAAKPAGSS------TPS 874
            :    :|..:.|                        |.:.||:..||   :||.||      ||.
Yeast   368 DGDKYVFSADFIIHGGVFVEKSKPTYPGTEFDISGENFDVSGTFNAE---EPAASSASAYSFTPG 429

  Fly   875 A----------------GTLLFSTLSE-------------------QERLESQKTNQQMNQSLNL 904
            :                |.:.||..|.                   |.|.||...|   |..:||
Yeast   430 SFDNSGDISLSLSESTKGEVTFSPYSNSGAFSFSNAILNGGSVSGLQRRAESGSVN---NGEINL 491

  Fly   905 NQNHSEVDAPPSEKKTPSN---------YPDS 927
            ....:.|...|.......|         |||:
Yeast   492 ENGSTYVVVEPVSGSGTINIISGNLYLHYPDT 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yrt	NP_650291.1	B41	60..250	CDD:214604
		FERM_N	62..124	CDD:286467
		FERM_M	143..250	CDD:278785
		FERM_C_NBL4_NBL5	246..339	CDD:270007
		FA	352..392	CDD:285894
		PHA03255	771..>924	CDD:165513	58/269 (22%)
HPF1	NP_014487.1	Hyphal_reg_CWP	337..617	CDD:403079	33/193 (17%)
HPF1	NP_014487.1	Herpes_BLLF1	<643..937	CDD:282904
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23280
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100