Protein Alignment yrt and FRMD5

DIOPT Version :9

• Sequence 1: NP_650291.1
• Gene: yrt / 41656
• FlyBaseID: FBgn0004049
• Length: 972
• Species: Drosophila melanogaster
• Sequence 2: NP_116281.2
• Gene: FRMD5 / 84978
• HGNCID: 28214
• Length: 570
• Species: Homo sapiens
• Alignment Length: 498
• Identity: 159/498 - (31%)
• Similarity: 259/498 - (52%)
• Gaps: 59/498 - (11%)

  Fly    38 ITSGGSSQIKPQRIVVNKNKIDCRVILLDNTDLSIELSKKALGSFLYEQVFYALDIIEKDYFGLQ 102
            :.||.|..:        :.:..|.|.|||:::.:..:.:.|.|.:|::.:.:.|:::||||||::
Human     5 LMSGSSRSL--------EREYSCTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIR 61

  Fly   103 FMDANHVKHWLDPTKPIKKQVKIGPPYTFRLKVKFYSSEPNTLREELTRYLFFLQLKQDLLEGRL 167
            |:|.:..:|||:.||.:.||::..||:|...:||||.::|..|:||:||||.|||:|:||..|||
Human    62 FVDPDKQRHWLEFTKSVVKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRL 126

  Fly   168 DCPEDKATELCALALQSELGDYDNQEHSAATVSEFRFVPEQTEDLEIAILDEYKT-CRGLTPAQA 231
            .|....|..|.|..||:|:||||:.:|.....|:|:|.|:.:|.||..|.:.:|| ..|.|||.:
Human   127 LCKTSDAALLAAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATS 191

  Fly   232 ETAFLNKAKWLDMYGVDMHTVLGKDGCEYHLGLTPTGILVFERDQKIGLFFWPKISKLDFKKKKL 296
            |..||.||:.|:.||||.|......|....|..||.|.:|.:.::::....|.:::||.|:.|..
Human   192 ELNFLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGKTF 256

  Fly   297 TLIVIEDDDEGREQEHTFVFRLYNEKACKHLWKCAVEHHTFFRLR--APVKGPSARQNFFRMGSR 359
            .|.|.:.:    |::....:.....:||||||||.:|:..|::|.  :.|:..|:...||: |||
Human   257 YLYVSQKE----EKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFK-GSR 316

  Fly   360 FRYSGRTEFQTTQQSR--ARRTVQFERR--------PSQRFASRQSHLLRERQKASQEAAVSAVA 414
            ||||||...:..:.|.  .|...:..|.        ||.....|.|.:.|.|::|...:.:..:.
Human   317 FRYSGRVAKEVMESSAKIKREPPEIHRAGMVPSRSCPSITHGPRLSSVPRTRRRAVHISIMEGLE 381

  Fly   415 SVNARAAAAAAAAAASQSPAPATPLVS-SQVSTPTPN-----NDNNNDAFDSLISTDQFITVTPS 473
            |:              :..|.:||:.| |...|..|:     .|:|...  ::|:.:.:   :|:
Human   382 SL--------------RDSAHSTPVRSTSHGDTFLPHVRSSRTDSNERV--AVIADEAY---SPA 427

  Fly   474 PSVL--TVIQNSAIIE------PDAACSGSISSSSQAAANFAS 508
            .|||  .|.::|..:.      ..|.||......|:|:...|:
Human   428 DSVLPTPVAEHSLELMLLSRQINGATCSIEEEKESEASTPTAT 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
yrt	NP_650291.1	B41	60..250	CDD:214604	84/190 (44%)
		FERM_N	62..124	CDD:286467	23/61 (38%)
		FERM_M	143..250	CDD:278785	52/107 (49%)
		FERM_C_NBL4_NBL5	246..339	CDD:270007	28/92 (30%)
		FA	352..392	CDD:285894	16/49 (33%)
		PHA03255	771..>924	CDD:165513
FRMD5	NP_116281.2	B41	19..210	CDD:214604	84/190 (44%)
		FERM_C_FRMD3_FRMD5	191..295	CDD:270013	35/107 (33%)
		Interaction with ROCK1. /evidence=ECO:0000269|PubMed:25448675	308..353		14/45 (31%)
		FA	309..354	CDD:370090	14/45 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	344..367		4/22 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	385..407		7/21 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151650
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740