DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yrt and frmd3

DIOPT Version :9

Sequence 1:	NP_650291.1	Gene:	yrt / 41656	FlyBaseID:	FBgn0004049	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	NP_001072510.1	Gene:	frmd3 / 779965	XenbaseID:	XB-GENE-1011845	Length:	585	Species:	Xenopus tropicalis

Alignment Length:	521	Identity:	159/521 - (30%)
Similarity:	251/521 - (48%)	Gaps:	82/521 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 CRVILLDNTDLSIELSKKALGSFLYEQVFYALDIIEKDYFGLQFMDANHVKHWLDPTKPIKKQVK 124
            |.:.|||:|::|..:.:...|.||.:.:....:::||||||::|:|....:|||||:||:.||:|
Frog    18 CTIRLLDDTEISFNIQRDTKGQFLLDYICNHYNLLEKDYFGIRFVDPEKQRHWLDPSKPVAKQMK 82

  Fly   125 IGPPYTFRLKVKFYSSEPNTLREELTRYLFFLQLKQDLLEGRLDCPEDKATELCALALQSELGDY 189
            ..||||...:||||..||..::|||||||.:||:|:|:..|||.|....|..|.|..:|:|:|||
Frog    83 SHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCCFADAAFLGACIVQAEIGDY 147

  Fly   190 DNQEHSAATVSEFRFVPEQTEDLEIAILDEYKT-CRGLTPAQAETAFLNKAKWLDMYGVDMHTVL 253
            |..||....:.:|:..|:|::.||..|::.:|. .||.:|:.:|...|.||..|:.||||.|...
Frog   148 DPDEHPDNYICDFKIFPKQSQKLERKIVEIHKNELRGQSPSVSEFNLLLKAHSLETYGVDPHPCK 212

  Fly   254 GKDGCEYHLGLTPTGILVFERDQKIGLFFWPKISKLDFKKKKLTLIVIEDDDEGREQEHTFVFRL 318
            ...|....||.|..|.:||:.:::|.|..||.|.|:.|..|...::|::     :|:::...:..
Frog   213 DSTGTTTFLGYTAAGFVVFQGNKRIHLIKWPDICKMKFDGKTFHVVVMQ-----KEKKNILTYHT 272

  Fly   319 YNEKACKHLWKCAVEHHTFFRL--RAPVKGPSARQNFFRMGSRFRYSGRTEFQTTQQSRARRTVQ 381
            ....||||||||.||:..|::.  .:.||..::...||: ||||||.|:...:..:.|.     :
Frog   273 STPAACKHLWKCGVENQAFYKYAKSSQVKTVTSSNIFFK-GSRFRYCGKVAKEVVEASS-----K 331

  Fly   382 FERRPSQRFA-----SRQSHLLRERQKASQEAAVSAVASVN------------------ARAAAA 423
            .:|.|.:...     ||.|:.|.::...:.|.....:.|.|                  .:.:.|
Frog   332 IQRDPPEVHRSLIPHSRSSYSLNKQLIINMEPLQPLIPSPNEEEEEEEEENQIDEGILLLQQSEA 396

  Fly   424 AAAAAASQSPA--------------------PATPLVSSQVST------PTPNNDNNNDAFDSLI 462
            ::|.....|||                    |.|  :|.||..      |||.::..:..|:|.:
Frog   397 SSAPVLGNSPARGLETTADVTHDEEESIREEPLT--ISEQVYNPSASLLPTPVDEGIDMLFNSPL 459

  Fly   463 -------STDQFITVTPSPSVLTVIQNSAIIEPDAACSGSISSSSQAAANF--ASLGRNSLKSNF 518
                   .||.|..:........:.:...:.|...|.|.|.        ||  .::..|:...:|
Frog   460 RAEREKDDTDSFEDLEADEHAFLIAEEEEMKEARKALSWSY--------NFIMGNMQLNAFLKSF 516

  Fly   519 S 519
            |
Frog   517 S 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yrt	NP_650291.1	B41	60..250	CDD:214604	82/190 (43%)
		FERM_N	62..124	CDD:286467	25/61 (41%)
		FERM_M	143..250	CDD:278785	45/107 (42%)
		FERM_C_NBL4_NBL5	246..339	CDD:270007	32/92 (35%)
		FA	352..392	CDD:285894	12/44 (27%)
		PHA03255	771..>924	CDD:165513
frmd3	NP_001072510.1	B41	17..209	CDD:214604	82/190 (43%)
		FERM_N	20..83	CDD:286467	25/62 (40%)
		FERM_M	101..209	CDD:278785	45/107 (42%)
		FERM_C_FRMD3_FRMD5	190..293	CDD:270013	38/107 (36%)
		FA	307..343	CDD:285894	12/41 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910