Protein Alignment yrt and EPB41L4A

DIOPT Version :10

• Sequence 1: NP_650291.1
• Gene: yrt / 41656
• FlyBaseID: FBgn0004049
• Length: 972
• Species: Drosophila melanogaster
• Sequence 2: NP_001334816.1
• Gene: EPB41L4A / 64097
• HGNCID: 13278
• Length: 708
• Species: Homo sapiens
• Alignment Length: 800
• Identity: 234/800 - (29%)
• Similarity: 360/800 - (45%)
• Gaps: 161/800 - (20%)

  Fly    60 CRVILLDNTDLSIE-----LSKKALGSFLYEQVFYALDIIEKDYFGLQFMDANHVKHWLDPTKPI 119
            |.|:|||.:.|::.     :.|...||.:.:.||:.::::|.|||||::.|.:|..:||||.|.:
Human    13 CEVLLLDESKLTLTTQQQGIKKSTKGSVVLDHVFHHVNLVEIDYFGLRYCDRSHQTYWLDPAKTL 77

  Fly   120 ---KKQVKIGPPYTFRLKVKFYSSEPNTLREELTRYLFFLQLKQDLLEGRLDCPEDKATELCALA 181
               |:.:..|||||....:|||:.:|..|:||:|||.||||:|||:|:|||.||.:.|.:|.|.|
Human    78 AEHKELINTGPPYTLYFGIKFYAEDPCKLKEEITRYQFFLQVKQDVLQGRLPCPVNTAAQLGAYA 142

  Fly   182 LQSELGDYDNQEHSAATVSEFRFVPEQTEDLEIAILDEYKTCRGLTPAQAETAFLNKAKWLDMYG 246
            :||||||||..:|:|..|||:||||:|.|:||.||...:||..|..|::||..:|..||.|:|||
Human   143 IQSELGDYDPYKHTAGYVSEYRFVPDQKEELEEAIERIHKTLMGQIPSEAELNYLRTAKSLEMYG 207

  Fly   247 VDMHTVLGKDGCEYHLGLTPTGILVFERDQKIGLFFWPKISKLDFKKKKLTLIVIEDDDEGREQE 311
            ||:|.|.|::..||.|||||.|::|::..:::|.:|||:|:|:.||:.:..|.|:..|.    .|
Human   208 VDLHPVYGENKSEYFLGLTPVGVVVYKNKKQVGKYFWPRITKVHFKETQFELRVLGKDC----NE 268

  Fly   312 HTFVFRLYNEKACKHLWKCAVEHHTFFRLRAPVKGPSARQNFFRMGS---RFRYSGRTEFQTTQQ 373
            .:|.|...::.||||||||:||||||||: ...:..|..:...:.||   :.||||||..|.::.
Human   269 TSFFFEARSKTACKHLWKCSVEHHTFFRM-PENESNSLSRKLSKFGSIRYKHRYSGRTALQMSRD 332

  Fly   374 SRARRTVQFERRPSQRFASRQSHLLRERQKASQEAAVSAVASVNARAAAAAAAAAASQSPAPATP 438
                .::|.. ||.|       ::.|.|.|...:..                        |...|
Human   333 ----LSIQLP-RPDQ-------NVTRSRSKTYPKRI------------------------AQTQP 361

  Fly   439 LVSSQVSTPTPNNDN-NNDAFDSLISTDQFITVTPSPSVLTVIQNSAIIEPDAACSGSISSSSQA 502
            ..|:.:|..|.|.:| .|:....:|:        |||           ::.........|..:|.
Human   362 AESNSISRITANMENGENEGTIKIIA--------PSP-----------VKSFKKAKNENSPDTQR 407

  Fly   503 AANFASLGRNSLKSNFSNEDPAYSKIGSIGKASGLTVKLDPDYTPPYSPNATKNFDETNPFRNAT 567
            :.:.|....|..:|...|.....:|....            .||...:|:...:.|...|.|...
Human   408 SKSHAPWEENGPQSGLYNSPSDRTKSPKF------------PYTRRRNPSCGSDNDSVQPVRRRK 460

  Fly   568 SSHHG----------SFGKASISSGQLSVKSGLSDKDRELDSLLKSIVKDPSPSVLANEAINDAN 622
            :.:.|          |..:.:.|||..|..|     :||.......|.::       |:.::.|.
Human   461 AHNSGEDSDLKQRRRSRSRCNTSSGSESENS-----NREYRKKRNRIRQE-------NDMVDSAP 513

  Fly   623 SIRVTINKTFD---MDHNTETLKRLSNANEKPNNQVK---LANVNTTALPPGNIKCNILKARVEE 681
            .....:.:..:   .|.|....:..|. :..|:.|.|   ..::....:.|..:.        ||
Human   514 QWEAVLRRQKEKNQADPNNRRSRHRSR-SRSPDIQAKEELWKHIQKELVDPSGLS--------EE 569

  Fly   682 ELGAGGNAKLTNQ---MFVPAAHSSNMHTSNTNSSNNHAHSDGPDSLNATYISVGGDKLTL--SI 741
            :|......|:..|   :.:..:||...:.....|.    .|||..|:    :|....|..|  .:
Human   570 QLKEIPYTKIETQGDPIRIRHSHSPRSYRQYRRSQ----CSDGERSV----LSEVNSKTDLVPPL 626

  Fly   742 PEQKPSTGSSSSSSTSSTATTTTN-------GN-------GPYSNATFVS------GFSAP---- 782
            |..:.|....|..:|......|:.       ||       ...|:.|.:.      |:||.
Human   627 PVTRSSDAQGSGDATVHQGVQTSRPRKGRELGNLSLNKALQKVSHNTLLDEVILGLGWSAHEVMW 691

  Fly   783 LTPPSSLPANLNNTGSGCNT 802
            ...|:||.|.:   |||.||
Human   692 TESPTSLAAVV---GSGINT 708

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
yrt	NP_650291.1	B41	60..250	CDD:214604	95/197 (48%)
		FERM_C_NBL4_NBL5	246..339	CDD:270007	43/92 (47%)
		FA	352..393	CDD:462582	13/43 (30%)
		PHA03255	771..>924	CDD:165513	13/41 (32%)
EPB41L4A	NP_001334816.1	B41	13..211	CDD:214604	95/197 (48%)
		FERM_C_NBL4_NBL5	207..296	CDD:270007	43/92 (47%)
		FA	311..355	CDD:462582	16/55 (29%)