Protein Alignment yrt and EPB41L5

DIOPT Version :10

• Sequence 1: NP_650291.1
• Gene: yrt / 41656
• FlyBaseID: FBgn0004049
• Length: 972
• Species: Drosophila melanogaster
• Sequence 2: XP_006712714.1
• Gene: EPB41L5 / 57669
• HGNCID: 19819
• Length: 740
• Species: Homo sapiens
• Alignment Length: 880
• Identity: 338/880 - (38%)
• Similarity: 451/880 - (51%)
• Gaps: 197/880 - (22%)

  Fly     3 RFLSRRKVRNN-YVDNSREGGGATSSAVGVAGGGGAITSGGSSQIKPQRIVVNKNKIDCRVILLD 66
            |.|.||.:|.: ..:..||...|.:.          |.:.|.|          |:.|.|||.|||
Human     7 RTLGRRSMRKHAEKERLREAQRAATH----------IPAAGDS----------KSIITCRVSLLD 51

  Fly    67 NTDLSIELSKKALGSFLYEQVFYALDIIEKDYFGLQFMDANHVKHWLDPTKPIKKQVKIGPPYTF 131
            .||:|::|.|||.|..|::|:.|.||:||.|||||:|||:..|.||||.||.||||||||.||..
Human    52 GTDVSVDLPKKAKGQELFDQIMYHLDLIESDYFGLRFMDSAQVAHWLDGTKSIKKQVKIGSPYCL 116

  Fly   132 RLKVKFYSSEPNTLREELTRYLFFLQLKQDLLEGRLDCPEDKATELCALALQSELGDYDNQEHSA 196
            .|:|||||||||.||||||||||.||||||:|.|:||||.|.|.:|.|..||:||||||..|||.
Human   117 HLRVKFYSSEPNNLREELTRYLFVLQLKQDILSGKLDCPFDTAVQLAAYNLQAELGDYDLAEHSP 181

  Fly   197 ATVSEFRFVPEQTEDLEIAILDEYKTCRGLTPAQAETAFLNKAKWLDMYGVDMHTVLGKDGCEYH 261
            ..||||||||.|||::|:||.:::|..||.|||||||.:|||||||:|||||||.|..:||.:|.
Human   182 ELVSEFRFVPIQTEEMELAIFEKWKEYRGQTPAQAETNYLNKAKWLEMYGVDMHVVKARDGNDYS 246

  Fly   262 LGLTPTGILVFERDQKIGLFFWPKISKLDFKKKKLTLIVIEDDDEGREQEHTFVFRLYNEKACKH 326
            |||||||:||||.|.||||||||||::|||||.||||:|:||||:|:||||||||||.:.|||||
Human   247 LGLTPTGVLVFEGDTKIGLFFWPKITRLDFKKNKLTLVVVEDDDQGKEQEHTFVFRLDHPKACKH 311

  Fly   327 LWKCAVEHHTFFRLRAPVKGPSARQNFFRMGSRFRYSGRTEFQTTQQSRARRTVQFERRPSQRFA 391
            |||||||||.|||||.||:..|.|..|.|:||||||||:||:|||:.::|||:..||||||:|::
Human   312 LWKCAVEHHAFFRLRGPVQKSSHRSGFIRLGSRFRYSGKTEYQTTKTNKARRSTSFERRPSKRYS 376

  Fly   392 SRQSHLLRERQKASQEAAVSAVASVNARAAAAAAAAAASQSPAPATPLVSSQVSTPTPNNDNNND 456
            .|   .|:.:..|::...:|...:|:.: :..:..|...:|..|.:|.:|   |.|.|....|
Human   377 RR---TLQMKACATKPEELSVHNNVSTQ-SNGSQQAWGMRSALPVSPSIS---SAPVPVEIEN-- 432

  Fly   457 AFDSLISTDQF--------ITVTPSPSVLTVIQNSAIIEPDAACSGSISSSSQAAANFASLGRNS 513
             ......|||.        |.:..||.:|.......|...|.      ..:|||
Human   433 -LPQSPGTDQHDRKCIPLNIDLLNSPDLLEATIGDVIGASDT------METSQA----------- 479

  Fly   514 LKSNFSNEDPAYSKIGSIGKASGLTVKLDPDYTPPYSPNATKNFDETNPFRNATSSHHGSFGKAS 578
                          :..:..|:.|
Human   480 --------------LNDVNVATRL----------------------------------------- 489

  Fly   579 ISSGQLSVKSGLSDKDRELDSL------LKSIVKDPSPSVLANEAINDANSIRVTINKTFDMDHN 637
                     .||.:.:.|.::|      ||.:..:.||      .::..::|.|.||...::...
Human   490 ---------PGLGEPEVEYETLKDTSEKLKQLEMENSP------LLSPRSNIDVNINSQEEVVKL 539

  Fly   638 TETLKRLSNANEKPNNQVKLANVNTTALPPGNIKCNILKARVEEELGAGGNAKLTNQMFVPAAHS 702
            ||  |.|:|..|.|       .:|...:|| :.|.|||||:||      ...|:|.:..:.:..:
Human   540 TE--KCLNNVIESP-------GLNVMRVPP-DFKSNILKAQVE------AVHKVTKEDSLLSHKN 588

  Fly   703 SNMHTSNTNSSNNHAHSDGPDSLNATYISVGGDKL-TLSI--PEQKPSTGSSSSSSTSSTATTTT 764
            :|:..:.|||:          .||...:.:..:.| ||.:  |....|....::....:...:.|
Human   589 ANVQDAATNSA----------VLNENNVPLPKESLETLMLITPADSGSVLKEATDELDALLASLT 643

  Fly   765 NGNGPYSNATFVSGFSAPLTPPSSLP---------ANLNNTGSGCNTTLT---------SVTTIS 811
            .....::.|..||..|. :||...:|         ..::|..:||...||         .::.||
Human   644 ENLIDHTVAPQVSSTSM-ITPRWIVPLCVYLPQQSGAMSNGLAGCEMLLTGKEGHGNKDGISLIS 707

  Fly   812 TPSSPTATVSTTASESVAPALSNA--SAAEILINE 844
            .|               ||.|.:|  |:..||..|
Human   708 PP---------------APFLVDAVTSSGPILAEE 727

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
yrt	NP_650291.1	B41	60..250	CDD:214604	129/189 (68%)
		FERM_C_NBL4_NBL5	246..339	CDD:270007	71/92 (77%)
		FA	352..393	CDD:462582	25/40 (63%)
		PHA03255	771..>924	CDD:165513	23/94 (24%)
EPB41L5	XP_006712714.1	FERM_F1_EPB41L5	41..126	CDD:340725	53/84 (63%)
		B41	44..235	CDD:214604	129/190 (68%)
		FERM_C_NBL4_NBL5	231..324	CDD:270007	71/92 (77%)
		FA	337..378	CDD:462582	25/40 (63%)