DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yrt and CG34347

DIOPT Version :9

Sequence 1:	NP_650291.1	Gene:	yrt / 41656	FlyBaseID:	FBgn0004049	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	NP_001368952.1	Gene:	CG34347 / 5740668	FlyBaseID:	FBgn0085376	Length:	1519	Species:	Drosophila melanogaster

Alignment Length:	1063	Identity:	281/1063 - (26%)
Similarity:	448/1063 - (42%)	Gaps:	249/1063 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 KPQRIVVNKNKIDCRVILLDNTDLSIELSKKALGSFLYEQVFYALDIIEKDYFGLQFMDANHVKH 111
            :|.||      :..|:.|||.|:...|:.....|..|.:.||..|::||..|||::::|..:..|
  Fly     6 RPSRI------MSVRINLLDETEFIHEIKDDLPGQALLDVVFARLNLIETSYFGIRYIDEENQTH 64

  Fly   112 WLDPTKPIKKQVK-IGPPYTFRLKVKFYSSEPNTLREELTRYLFFLQLKQDLLEGRLDCPEDKAT 175
            ||||...|.:|:| ...||.....||||:::|..|.||:|||..|||:|||:|:|||....:.|.
  Fly    65 WLDPASRISRQLKPKSDPYDLYFGVKFYAADPCKLLEEITRYQLFLQVKQDVLQGRLPVAFELAA 129

  Fly   176 ELCALALQSELGDYDNQEHSAATVSEFRFVPEQTEDLEIAILDEYKTCRGLTPAQAETAFLNKAK 240
            ||.|..:||||||||.:.||...|||||.:|.|:.:||..:.:.::..:|::|:.||..:|:|.|
  Fly   130 ELGAFVVQSELGDYDQRRHSKGYVSEFRLLPNQSNELETRVSELHQQLKGMSPSSAELNYLDKVK 194

  Fly   241 WLDMYGVDMHTVLGKDGCEYHLGLTPTGILVFERDQKIGLFFWPKISKLDFKKKKLTLIVIEDDD 305
            |.||||||:|.|||:|..||.|||||:||:|......:..::||:|:|:.:|.:...|.:.:.::
  Fly   195 WHDMYGVDLHPVLGEDSVEYFLGLTPSGIVVLRNKTTVAHYYWPRIAKVYYKGRYFMLRISDKNN 259

  Fly   306 EGREQEHTFVFRLYNEKACKHLWKCAVEHHTFFR-LR-APVKGPSARQ---NFFRMGSRFRYSGR 365
            |    ..|:.|....:.||||||:|.||||.||| :| ||:  ||::.   :.|::|||||:| |
  Fly   260 E----LSTYGFETPRKSACKHLWRCCVEHHAFFRQVRVAPL--PSSQSHAADLFQLGSRFRHS-R 317

  Fly   366 TEFQTTQQ--SRARRTVQFERRPSQRFASRQSHLLRERQKASQEAAVSAVASVNARAAAAAAAAA 428
            .:.||.:.  |..|....|.|.||:|...|   ::.:...::.....:...:.|......:.|..
  Fly   318 PDKQTEKDALSAGRSPPAFTRTPSKRQPRR---VIDDFFNSNGNGNGNGNGNGNGHGHGGSGAGT 379

  Fly   429 ASQS--------PAPATPLVS--------SQVSTPT----------PNNDN---NNDAFDSLIST 464
            ....        |.|....:|        |..|.||          .||::   ||::..:|.:.
  Fly   380 LGGGSHMGNRPLPQPGMGTISNNYDSPYRSTYSIPTSLGIRPCHQQQNNNSSSYNNNSGGNLQTP 444

  Fly   465 D--------------QFITVTPSPSVLTVIQNSAII---------------------EPDAACSG 494
            |              |......:||....:::::..                     ...::.:|
  Fly   445 DSPRSTRSAPWPRSQQRSLFGHNPSSPRSVRSASTAGGGLHHHHSHHSHGHGTSHHPHHQSSSAG 509

  Fly   495 SISSSS------QAAANFAS-----LGRNSLKSNFSNEDPAYSK-----------IGSIGKASGL 537
            :.||:|      :|:::.||     ...:|::|:.||:..:..|           ...:.:.||.
  Fly   510 ATSSTSHHHRQQRASSSSASHQQQRYRSSSVESHSSNDSRSTRKHKHRHRRTSDNESELSRGSGR 574

  Fly   538 TVK----------------------LDPDYT--PPYS--------PNATKNFDETNPFRNATSSH 570
            :.:                      .|.|.|  ..||        ..:|:..|.|:.:|......
  Fly   575 SGRSGRSHHRKHRRSHRHRRDSAGGSDHDSTRGRSYSGHRSSSMRSGSTELIDSTSQWREVQRRQ 639

  Fly   571 -HGSFGKASISSGQLSVKSGL-------SDKDRELDSLLKS--IVKDPSPSVLANEAIND--ANS 623
             ..|.|::|:....:| ||.:       :|...:..|..||  ..|:.|||...:...|.  |..
  Fly   640 AEASLGQSSVQQAAVS-KSSMVARSLHSNDSHSDTHSHHKSRRHRKNKSPSESRSRMWNSELAKH 703

  Fly   624 IRVTINKTFDMDHN---------TETLKRLSNANEKPNNQVKLANVNTTALPPGNIKCNILKARV 679
            ::..:..|..|...         .||..:.||:|.|.:.....::|...:...||...|
  Fly   704 LQFDLVDTEGMSEQQLREIPYTVVETTSKRSNSNLKIHKSNSKSSVGAKSTGSGNTITN------ 762

  Fly   680 EEELGAG-GNA-KLTNQMFVPAAHSSNMHTSNTNSSNNHAHSDGPDSLNATYISVGGDKLTLSIP 742
                |:| ||| :..|::       ..:......|::.|..:.||        ..||
  Fly   763 ----GSGSGNAGQARNRV-------DRIRGLYYQSTHPHEANGGP--------GAGG-------- 800

  Fly   743 EQKPSTGSSSSSSTSSTATTTTNGNG------PYSNATFVSGFSAPLTP--PSSLPANLNNTGSG 799
             ..|..||..|:||.|:.....| ||      ..|...|:|...:.|:|  .|:|..:..:|.||
  Fly   801 -HAPKNGSIRSASTISSRECERN-NGLVRMMSSMSMGDFISPTGSNLSPLENSALRVSHEHTDSG 863

  Fly   800 CNTTLTSVTTISTPSSPTATVSTTASESVAPALSNASAAEILINEIFINNIINNNASGSITAETA 864
            ...           ....|..|..:|:|.....:.:|.|                :|||     .
  Fly   864 LGA-----------DQDYAYSSERSSDSTRYGTNKSSGA----------------SSGS-----H 896

  Fly   865 AKPAGSSTPSAGTLLFSTLSEQER----LESQKTNQQMNQSLNLNQNHSEVDAPPSEKKTPSNYP 925
            .|..||:..:...|:..|:|.|::    |.:|:..||.:.......:.|..:...|....|.:.|
  Fly   897 RKSGGSAGGNYNNLMQQTVSNQQQQQRSLFAQQQRQQKSTYKYATSSPSSTNPGSSSGLAPVHNP 961

  Fly   926 DSSRIPF----PSSSNSKDMVSP 944
            .||..|.    |:|:.:.:..||
  Fly   962 GSSSNPSSSQNPNSATNSNQQSP 984

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yrt	NP_650291.1	B41	60..250	CDD:214604	85/190 (45%)
		FERM_N	62..124	CDD:286467	23/61 (38%)
		FERM_M	143..250	CDD:278785	53/106 (50%)
		FERM_C_NBL4_NBL5	246..339	CDD:270007	39/92 (42%)
		FA	352..392	CDD:285894	17/41 (41%)
		PHA03255	771..>924	CDD:165513	33/158 (21%)
CG34347	NP_001368952.1	B41	13..204	CDD:214604	85/190 (45%)
		FERM_C_NBL4_NBL5	200..289	CDD:270007	39/92 (42%)
		FA	305..347	CDD:400882	17/42 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D241659at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23280
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.020