DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yrt and si:dkey-178k16.1

DIOPT Version :9

Sequence 1:	NP_650291.1	Gene:	yrt / 41656	FlyBaseID:	FBgn0004049	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	XP_009294955.1	Gene:	si:dkey-178k16.1 / 569390	ZFINID:	ZDB-GENE-090312-61	Length:	1273	Species:	Danio rerio

Alignment Length:	1008	Identity:	263/1008 - (26%)
Similarity:	409/1008 - (40%)	Gaps:	249/1008 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 SSQIKPQRIVVNKNK------IDCRVILLDNTDLSIELSKKALGSFLYEQVFYALDIIEKDYFGL 101
            ||:..|.|:..:..|      :..:|:|||.:.....:.|...|..|.:.|...|:::|||||||
Zfish    33 SSEKTPSRMSRSPQKSKRPKTVPVKVLLLDGSAYESGVEKLCKGQVLLDMVCEHLNLLEKDYFGL 97

  Fly   102 QFMDANHVKHWLDPTKPIKKQVKIGPPYTFRLKVKFYSSEPNTLREELTRYLFFLQLKQDLLEGR 166
            .|.|....|:||||:|.||||:::| |:.|...||||..:|:.|.|::|||...|||::|:|.||
Zfish    98 SFSDTECQKNWLDPSKEIKKQIRVG-PWHFSFAVKFYPPDPSQLIEDITRYYLCLQLREDILSGR 161

  Fly   167 LDCPEDKATELCALALQSELGDYDNQEHSAATVSEFRFVPEQTEDLEIAILDEYKTCRGLTPAQA 231
            |.|.......|.:.|:|:||||||.:||....::||||.|.||.:||..:::.::|.||::||:|
Zfish   162 LPCSFVTHALLGSYAIQAELGDYDPEEHGPDYINEFRFAPNQTRELEERVMELHRTYRGMSPAEA 226

  Fly   232 ETAFLNKAKWLDMYGVDMHTVLGKDGCEYHLGLTPTGILVFERDQKIGLFFWPKISKLDFKKKKL 296
            |..||..||.|.|||||:|.....:|.:..||:..:|:|::....:|..|.||||.|:.:|:...
Zfish   227 EINFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCASGLLIYRDRLRINRFAWPKILKISYKRSNF 291

  Fly   297 TLIVIEDDDEGREQEHTFVFRLYNEKACKHLWKCAVEHHTFFRLRAPVKGPSARQNFFRMGSRFR 361
            .:.:...:.|  :.|.|..|:|.|.:|.|.|||..:||||||||.:|...|   :.|..:||:||
Zfish   292 YIKIRPGEYE--QFESTIGFKLPNHRASKRLWKVCIEHHTFFRLVSPEPPP---KGFLVIGSKFR 351

  Fly   362 YSGRTEFQTTQQSRA--RRTVQFERRPSQRF-ASR----QSHLLRERQKASQEAAVSAVASVNAR 419
            |||||:.|:.|.|..  |...||||..|:|: .||    :|.|.....:.||.
Zfish   352 YSGRTQAQSRQASALIDRPAPQFERSISRRYLLSRSIDGESALGDTMDRLSQH------------ 404

  Fly   420 AAAAAAAAAASQSPAPATPL--VSSQVSTPTPNNDNNNDAFDSLISTDQFITVTPSPSVLTVIQN 482
                     .|..|.|:.|.  :......|:.:.|.:.|       .:|              :.
Zfish   405 ---------TSSEPVPSLPRDELDQDYLEPSLDQDLDQD-------HEQ--------------EE 439

  Fly   483 SAIIEPDAACSGSISSSSQAAANFASLGRNSLKSNFSNEDPAYSKIGSIGKASGLTVKLDPDYTP 547
            ...:|.|:..|.::....:.|.:                 |..||           .:||.|.||
Zfish   440 EQRLESDSTPSKTVELKREEAGS-----------------PVDSK-----------TELDQDLTP 476

  Fly   548 PYSPNATKNFDETNPFRNATSSHHGSFGK-------------------ASISSGQLSVKSGLSDK 593
              .|...:..|:.   .:....|..|..:                   :..|||....|...|::
Zfish   477 --RPKQEQFLDKP---EDVLQKHQASINELKRALREPNSKLVHREKRLSGASSGSTPEKKSASEE 536

  Fly   594 ----------DRELDSLLKSIVKDPSPSVLA---------NEAINDANSIRVTINKTFDMDHNTE 639
                      .|:| .|.|...|..||.|.:         ::.:.:.|.|.|.
Zfish   537 SLLIEKQDGCQRDL-PLSKKDEKSRSPRVASLATGFNRETDDRVREKNIISVA------------ 588

  Fly   640 TLKRLSNAN----EKP-NNQVKLANVNTTALPPGNIKCNILKARVEEELGAGGNAKLTNQMFVPA 699
              ||.|..|    ||| .|:.|     :.||...:.:               |...|..:.:
Zfish   589 --KRTSTENILSPEKPLRNRAK-----SPALRYNHFQ---------------GINSLDEKAY--- 628

  Fly   700 AHSSNMHTSNTNSSNNHAHSDGPDSLNATYIS--VGGDKLTLSIPEQKPSTGSSSSSSTSSTATT 762
               .|.|:.:...|.|..|::|.|    ||.:  :.|||..:.:              |:....|
Zfish   629 ---DNGHSHDRPLSENVIHTNGCD----TYATERLWGDKKYMGV--------------TNIEHET 672

  Fly   763 TTNGNGPYSNATFVSGFSAPLTPPSSLPANLNNTGSGC----------NT--TLTSVTTISTPSS 815
            |......|...:|  |.::|.........:..|. |.|          ||  ||...|:.:.|..
Zfish   673 TNQDLARYVERSF--GEASPNAAMDKYMRDRYNE-SRCERQSYEKEPENTRATLLKQTSKADPKG 734

  Fly   816 PTATV---STTASES-------VAP--------------ALSNASAAEILINEIFINNIINNNAS 856
            ..:|:   .:|||::       :.|              |......:|..|:..|..:...|:..
Zfish   735 KGSTIQRHDSTASDTSQSELKRIVPLKPERSKKLKDRKGAKLQGQPSERSISGSFDESEGINSKE 799

  Fly   857 GSITAETAAKPAGSSTPSAGTLLFSTLSEQE---RLESQKTNQQMNQSL----NLNQNHSEVDAP 914
            ..:..|.|......|..||......|.::|:   ...:.:|.:.:.||:    .|....:.:|..
Zfish   800 DQVVFENALDTLSQSKNSATLESIGTFAKQDWASNYHNWETREYIRQSVQDRPQLRDLKNNIDHR 864

  Fly   915 PSEKKTPSNYPDS-SRIPFPSSSN--SKDMVSP 944
            .|.::....:.|. ....||::|.  :.|.::|
Zfish   865 LSIEQDQFLFDDPLFMFDFPTNSTFPAFDQIAP 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yrt	NP_650291.1	B41	60..250	CDD:214604	87/189 (46%)
		FERM_N	62..124	CDD:286467	28/61 (46%)
		FERM_M	143..250	CDD:278785	51/106 (48%)
		FERM_C_NBL4_NBL5	246..339	CDD:270007	33/92 (36%)
		FA	352..392	CDD:285894	20/42 (48%)
		PHA03255	771..>924	CDD:165513	35/195 (18%)
si:dkey-178k16.1	XP_009294955.1	B41	56..245	CDD:214604	87/189 (46%)
		FERM_N	58..120	CDD:286467	28/61 (46%)
		FERM_M	138..245	CDD:278785	51/106 (48%)
		FERM_C_4_1_family	240..333	CDD:270005	35/94 (37%)
		FA	342..383	CDD:285894	20/40 (50%)
		SAB	482..522	CDD:282265	3/42 (7%)
		4_1_CTD	<1210..1261	CDD:283537
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910