DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yrt and EPB41L4B

DIOPT Version :9

Sequence 1:	NP_650291.1	Gene:	yrt / 41656	FlyBaseID:	FBgn0004049	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	XP_011517092.1	Gene:	EPB41L4B / 54566	HGNCID:	19818	Length:	941	Species:	Homo sapiens

Alignment Length:	971	Identity:	333/971 - (34%)
Similarity:	454/971 - (46%)	Gaps:	239/971 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLRFLSR---RKVRNNY-----------VDNSREGG-------GATSSAVGVAGGGGAITSGGSS 44
            |||||.|   |:....|           :.:.|:||       .|:|||:..|.||....:||..
Human     1 MLRFLRRTFGRRSMQRYARGAAGRGAAGLGDERDGGPRGGPAAAASSSALPAAPGGSVFPAGGGP 65

  Fly    45 QIKPQRIV------VNKNKIDCRVILLDNTDLSIELSKKALGSFLYEQVFYALDIIEKDYFGLQF 103
            .:.....|      ..|..:.|||.|||.|::|::|.|.|.|..|::|:.|.||::|.|||||||
Human    66 LLTGGAAVHISAAGAAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQF 130

  Fly   104 MDANHVKHWLDPTKPIKKQVKIGPPYTFRLKVKFYSSEPNTLREELTRYLFFLQLKQDLLEGRLD 168
            :|:..|.||||..||||||:||||.|....:||:||||||.||||.|||||.|||:.|:|.|:|.
Human   131 LDSAQVAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLK 195

  Fly   169 CPEDKATELCALALQSELGDYDNQEHSAATVSEFRFVPEQTEDLEIAILDEYKTCRGLTPAQAET 233
            ||.:.|.||.||.||:|||:.:..||:...||||||:|.|||.:|..|...:|.|||.:|||||.
Human   196 CPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAEL 260

  Fly   234 AFLNKAKWLDMYGVDMHTVLGKDGCEYHLGLTPTGILVFERDQKIGLFFWPKISKLDFKKKKLTL 298
            ::|||||||:|||||||.|.|:|||||.|||||||||:||...||||||||||:|:||||.||||
Human   261 SYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLTL 325

  Fly   299 IVIEDDDEGREQEHTFVFRLYNEKACKHLWKCAVEHHTFFRLRAPVKGPSARQNFFRMGSRFRYS 363
            :|:||||:||||||||||||.:.:.||||||||||||.|||||.|....|.|.:|.|:|||||:|
Human   326 VVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRLGSRFRFS 390

  Fly   364 GRTEFQTTQQSRARRTVQFERRPSQRFASRQSHLLRERQKASQEAAVSAVASVNARAAAAAAAAA 428
            ||||:|.|..||.|||..|||:||:|:.||:....    |||
Human   391 GRTEYQATHGSRLRRTSTFERKPSKRYPSRRHSTF----KAS----------------------- 428

  Fly   429 ASQSPAPATPLVSSQVSTPT-PNNDNNNDAFDSLISTDQFITVTPSPSVLTVIQNSAIIEPDAAC 492
                    .|::::|:.:.| |...|....:...|...|......||:|...:.:..:...|...
Human   429 --------NPVIAAQLCSKTNPEVHNYQPQYHPNIHPSQPRWHPHSPNVSYPLPSPVLSSSDRLP 485

  Fly   493 SGSISSSSQAAANFASLGRNSLKSNFSNEDPAYSKIGSIGKASGLTVKLDPDYTPPYSPNATKNF 557
            .| |..:.......|:.||:..:....::...:|..       .|::.|:....|..|||::..
Human   486 FG-IEENGGTPFLTAASGRHHHQHQHQHQHQHHSNY-------SLSLTLENKEGPLRSPNSSSK- 541

  Fly   558 DETNPFRNATSSHHGSFGKASISSGQLSVKSGLSDKDRELDSLLKSIVKDPSPSVLANEAINDAN 622
                           |..|.|..:..|..::....|..||:::..:   .|.|
Human   542 ---------------SLTKLSPGTPALFSEAAAHLKKLELETVKAA---GPWP------------ 576

  Fly   623 SIRVTINKTFDMDHNTETLKRLSNANEKPNNQVKLANVNTTALP---PGNIKCNILKARVEEELG 684
            .:.:.|||                |.||   :|....:.|..||   ..::|||||||::|
Human   577 PLHININK----------------AEEK---KVSEKTLQTPLLPSPVADHVKCNILKAQLE---- 618

  Fly   685 AGGNAKLTNQMFVPAAHSSNMHTSNTNSSNNHAHSDGPDSLNATYISVGGDKLTLSIPEQKPSTG 749
                                                     ||:.:::.|.|      |:.|...
Human   619 -----------------------------------------NASRVNIQGGK------EESPFVN 636

  Fly   750 SSSSSSTSSTATTTTNGNGPYSNATFVSGFSAP-LTPP----------------SSLPANLN--- 794
            .:..||....:..:..   |....|.......| :.||                ..||.:|.
Human   637 INKKSSLQDASVRSPI---PIRVETAQPAVEKPEIKPPRVRKLTRQYSFNRSDEDDLPPDLAEAV 698

  Fly   795 --NTGSGCNTTLTSVTTISTPSSPTATVSTTASESVAPALSNASAAEILINEIFINNIINNNASG 857
              .|.:..||| |:.|.:|.|..             :|.:.|.|:..            .:...|
Human   699 GVTTSTTTNTT-TAATQVSVPLP-------------SPKVQNVSSPH------------KSEGKG 737

  Fly   858 SIT--AETAAKPAGSSTPSAGTLLFSTLSEQERLESQKTNQQMNQSLNLNQNHSEVDAPPS 916
            .::  |::.:...|:.|...|.||.. .:|...|...|...|:::.|          |||:
Human   738 LLSPGAKSPSDRGGAFTLEPGDLLMD-FTEATPLHWLKATPQLSRPL----------APPA 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yrt	NP_650291.1	B41	60..250	CDD:214604	113/189 (60%)
		FERM_N	62..124	CDD:286467	35/61 (57%)
		FERM_M	143..250	CDD:278785	64/106 (60%)
		FERM_C_NBL4_NBL5	246..339	CDD:270007	72/92 (78%)
		FA	352..392	CDD:285894	25/39 (64%)
		PHA03255	771..>924	CDD:165513	33/170 (19%)
EPB41L4B	XP_011517092.1	B41	87..277	CDD:214604	113/189 (60%)
		FERM_N	89..151	CDD:286467	35/61 (57%)
		FERM_M	170..277	CDD:278785	64/106 (60%)
		FERM_C_NBL4_NBL5	273..366	CDD:270007	72/92 (78%)
		FA	379..419	CDD:285894	25/39 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151640
Domainoid	1	1.000	160	1.000	Domainoid score	I4057
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D129183at33208
OrthoFinder	1	1.000	-	-		FOG0003429
OrthoInspector	1	1.000	-	-		otm41440
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23280
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4251
SonicParanoid	1	1.000	-	-		X2790
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.840