DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yrt and Epb41l4b

DIOPT Version :9

Sequence 1:	NP_650291.1	Gene:	yrt / 41656	FlyBaseID:	FBgn0004049	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	XP_038966499.1	Gene:	Epb41l4b / 500464	RGDID:	1562988	Length:	897	Species:	Rattus norvegicus

Alignment Length:	992	Identity:	347/992 - (34%)
Similarity:	466/992 - (46%)	Gaps:	256/992 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLRFLSR---RKVRNNY-----------VDNSREGG-------GATSS--------AVGVAGGGG 36
            |||||.|   |:....|           :.:.|:||       .|:||        :|..||||.
  Rat     1 MLRFLRRTFGRRSMQRYARGAAGRGAAGLGDERDGGPRGGPAAAASSSVLPAAPGGSVFPAGGGP 65

  Fly    37 AITSGGSSQIKPQRIVVNKNKIDCRVILLDNTDLSIELSKKALGSFLYEQVFYALDIIEKDYFGL 101
            .:|.|.:..|......  |..:.|||.|||.|::|::|.|.|.|..|::|:.|.||::|.|||||
  Rat    66 LLTGGAAVHISASGAA--KATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGL 128

  Fly   102 QFMDANHVKHWLDPTKPIKKQVKIGPPYTFRLKVKFYSSEPNTLREELTRYLFFLQLKQDLLEGR 166
            ||:|:..|.||||.:||||||:|:||.|....:||:||||||.||||.|||||.|||:.|:|.|:
  Rat   129 QFLDSAQVTHWLDHSKPIKKQMKVGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGK 193

  Fly   167 LDCPEDKATELCALALQSELGDYDNQEHSAATVSEFRFVPEQTEDLEIAILDEYKTCRGLTPAQA 231
            |.||.:.|.||.||.||:|||:.:..||:...||||||:|.|||.:|..|...:|..||.:||||
  Rat   194 LKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKEYRGKSPAQA 258

  Fly   232 ETAFLNKAKWLDMYGVDMHTVLGKDGCEYHLGLTPTGILVFERDQKIGLFFWPKISKLDFKKKKL 296
            |.::|||||||:|||||||.|.|:|||||.|||||||||:||...||||||||||:|:||||.||
  Rat   259 ELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKL 323

  Fly   297 TLIVIEDDDEGREQEHTFVFRLYNEKACKHLWKCAVEHHTFFRLRAPVKGPSARQNFFRMGSRFR 361
            ||:|:||||:||||||||||||.:.:.||||||||||||.|||||.|....|||.:|.|:|||||
  Rat   324 TLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPSNSKSARSDFIRLGSRFR 388

  Fly   362 YSGRTEFQTTQQSRARRTVQFERRPSQRFASRQSHLLRERQKASQEAAVSAVASVNARAAAAAAA 426
            :|||||:|.|..||.|||..|||:||:|:.||:....    |||
  Rat   389 FSGRTEYQATHGSRLRRTSTFERKPSKRYPSRRHSTF----KAS--------------------- 428

  Fly   427 AAASQSPAPATPLVSSQVSTPT-PNNDNNNDAFDSLISTDQFITVTPSPSVLTVIQNSAIIEPDA 490
                      .|::::|:.:.| |...|....|...:...|......||:|...:.:.|:...:.
  Rat   429 ----------NPVIAAQLCSKTNPEVHNYQPQFHPNVHPSQPRWRPHSPNVSYPLPSPALSPTER 483

  Fly   491 ACSGSISSSSQAAANFASLGRNSLKSNFSNEDPAYSKIGSIGKASGLTVKLDPDYTPPYSPNATK 555
            ...|...:.....|..||...:....:.||              .||::.|:....|..|||::|
  Rat   484 LPFGLEENGGTPFAPKASGRHHHQHQHHSN--------------YGLSLTLENKEAPLRSPNSSK 534

  Fly   556 NFDETNPFRNATSSHHGSFGKASISSGQLSVKSGLSDKDRELDSLLKSIVKDPSPSVLANEAIND 620
            ...:.:|         |:....|.::..|        |..|||::..:   .|.|
  Rat   535 ALTKLSP---------GAPALYSEAAAHL--------KKLELDTVKAA---GPWP---------- 569

  Fly   621 ANSIRVTINKTFDMDHNTETLKRLSNANEKPNNQVKLANVNTTALP---PGNIKCNILKARVEEE 682
              ::.:.|||                |.||   :|....:.|..||   ..::|||||||::|..
  Rat   570 --ALHININK----------------AEEK---KVSEKTLQTPLLPSPVADHVKCNILKAQLENA 613

  Fly   683 LGAGGNAKLTNQMFVPAAHSSNMHTSNTNS------------------------------SNNHA 717
            .............||.....|::..:|..|                              |.|.:
  Rat   614 SRVNAQIGKEEPSFVNINKKSSLQDTNVRSPIPIRVEAAQPAVEKPEIKPPRVRRLTRQYSFNRS 678

  Fly   718 HSDG--PD---------------SLNATYISV--GGDKL-TLSIPEQKP-----STGSSSSSSTS 757
            ..|.  ||               :::||.:||  ...|: .:|.|::..     |.|:.|.|...
  Rat   679 DEDDLPPDLAEAVGATTATTTNTTMSATQVSVSLASPKIQQVSSPQKSEVKSPLSPGAKSPSDHG 743

  Fly   758 STATTTTNGNGP------YSNAT-FVSGFSAP------LTPPSSLPANLNNTGSGC--------- 800
            .|.|.     ||      ::.|| .....|:|      .:||.|||.....||. |
  Rat   744 GTFTL-----GPGDLLMDFTEATPLAEPASSPHCAHSRCSPPLSLPMKEETTGV-CMYPPIKTRL 802

  Fly   801 ----------------------------NTTLTSVTTISTPSSPTATVSTTASESVAPA------ 831
                                        ...|......|:|..||||: ...:|:||..
  Rat   803 IKTFPAEPMMNPFPDPFATGPQFAADFRENKLQCCPGQSSPLIPTATL-RPLTETVATVQTIYTS 866

  Fly   832 ---LSNASAAEILINEI 845
               :|.|::||.|..|:
  Rat   867 RKPVSLAASAETLRQEL 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yrt	NP_650291.1	B41	60..250	CDD:214604	111/189 (59%)
		FERM_N	62..124	CDD:286467	35/61 (57%)
		FERM_M	143..250	CDD:278785	63/106 (59%)
		FERM_C_NBL4_NBL5	246..339	CDD:270007	72/92 (78%)
		FA	352..392	CDD:285894	25/39 (64%)
		PHA03255	771..>924	CDD:165513	28/128 (22%)
Epb41l4b	XP_038966499.1	B41	87..277	CDD:214604	111/189 (59%)
		FERM_C_NBL4_NBL5	273..366	CDD:270007	72/92 (78%)
		FA	379..420	CDD:400882	25/40 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345133
Domainoid	1	1.000	160	1.000	Domainoid score	I3956
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D129183at33208
OrthoFinder	1	1.000	-	-		FOG0003429
OrthoInspector	1	1.000	-	-		otm45555
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23280
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2790
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.950