DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yrt and epb41l3a

DIOPT Version :9

Sequence 1:	NP_650291.1	Gene:	yrt / 41656	FlyBaseID:	FBgn0004049	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	XP_021325820.1	Gene:	epb41l3a / 445478	ZFINID:	ZDB-GENE-040822-8	Length:	1177	Species:	Danio rerio

Alignment Length:	1067	Identity:	265/1067 - (24%)
Similarity:	421/1067 - (39%)	Gaps:	230/1067 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 VDNSREGGGATSSAVGVAGGG----GAITSGGSSQI------------------KPQRIVVNKNK 57
            :||......|.|:.|.....|    |.:..|..:|:                  .|.:|......
Zfish    25 LDNQLPPAAAHSTPVKKDQAGEREVGGVPQGKPNQLSAEDDGSSHWSSSSKLNRSPAKISKKPKN 89

  Fly    58 IDCRVILLDNTDLSIELSKKALGSFLYEQVFYALDIIEKDYFGLQFMDANHVKHWLDPTKPIKKQ 122
            :.|::.|||.:|.:..:.|:..|..|:::|...|:::||||||:.|.|..:.|:||||.|.:|||
Zfish    90 MQCKITLLDGSDYTCVVEKRDKGQVLFDKVCEHLNLLEKDYFGITFRDVENQKNWLDPAKDMKKQ 154

  Fly   123 VKIGPPYTFRLKVKFYSSEPNTLREELTRYLFFLQLKQDLLEGRLDCPEDKATELCALALQSELG 187
            :: |..:.|...||||..||..|.|::|||...|||:.|:..|||.|.....|.|.:..:|||||
Zfish   155 IR-GVAWNFSFNVKFYPPEPALLSEDITRYYLCLQLRDDISSGRLPCSFATHTVLGSYTVQSELG 218

  Fly   188 DYDNQEHSAATVSEFRFVPEQTEDLEIAILDEYKTCRGLTPAQAETAFLNKAKWLDMYGVDMH-- 250
            |:|.:|..:...|||||.|:||:::|..|:|.:|..:|:|||:||..||...|.|.|||||:|
Zfish   219 DHDPEECGSEYTSEFRFAPQQTKEMEEKIIDLHKNYKGMTPAEAEMHFLENVKKLSMYGVDLHHA 283

  Fly   251 TVLGK-------------DGCEYHLGLTPTGILVFERDQKIGLFFWPKISKLDFKKKKLTLIVIE 302
            .::|:             :|.|..||:..:|:|::....:|..|.|||:.|:.:|:....:.:..
Zfish   284 KLIGRFFHCFSPAKGEDSEGVEIMLGVCSSGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRP 348

  Fly   303 DDDEGREQEHTFVFRLYNEKACKHLWKCAVEHHTFFRLRAPVKGPSARQNFFRMGSRFRYSGRTE 367
            .:.|  :.|.|..|:|.|.:|.|.|||..|||||||||..|...|   :.|..:||:|||||||:
Zfish   349 GEFE--QFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLVLPETPP---KKFLTLGSKFRYSGRTQ 408

  Fly   368 FQTTQQSR--ARRTVQFERRPSQRFASRQSHLLRERQKASQEAAVSAVASVNARAAAAAAAAAAS 430
            .||.:.|.  .|....|:|..|:|:...:|  |......:...|...:| ::.............
Zfish   409 AQTRRASSQIVRPAPYFQRSSSKRYTMSRS--LDGEMGTALYGAAKGIA-MSDLITTVTPEKKVE 470

  Fly   431 QSPAPATPLVSSQVSTPTPNNDNNNDAFDSLISTDQFITVTPSPSVLTVIQNSAIIEPDAACSGS 495
            :.|.|.....:.:...|....:...|            |.|.:.:||  ::|..|:|.|...:.:
Zfish   471 EEPQPQKHTHADKQMQPQTETETETD------------THTQTQTVL--VENVMILEDDDETTRA 521

  Fly   496 ISSSSQAAANFASLG-RNSL------------KSNFSNEDPAYSKIGSIGKASGLTVKLDPDYTP 547
            ...|..:.|..|.|. |..|            :|:..:|..|.:|              :.|.||
Zfish   522 TELSLPSPATPARLDTRTDLTDTAVDGELTATESDQEDESEAKTK--------------EADLTP 572

  Fly   548 PYSPNATKNFDETNPFRNATSSHHGSFGKASISSGQLSVKSGLSDKDRELDSL-LKSIVKDPSPS 611
            ........|..|..              :..:..|  :..:||::.::.|.|. |:|..::..|.
Zfish   573 DEQLKPQTNISELK--------------RTFLEGG--AEPAGLTEWEKRLSSSPLRSPRREEPPM 621

  Fly   612 V-------LANEAINDANSIRVT--INKTFDMDHNTETLKRLSNA----NEKPNNQVKLANVNT- 662
            :       :..|.:.:...:..|  :....|...|...:...|:.    |:.|..:...|.|.|
Zfish   622 IEPLELDEIKQEVVVETQEVAETQEVAAALDTQENNRKVDEESDGWVIINKVPPFEAHKAPVETR 686

  Fly   663 ------------TALPPG--------NIKCNIL-------------KARVEEELGAGGNAKLTNQ 694
                        .|.||.        ::....:             |..|||.|    ..|.|..
Zfish   687 DKSSIQPEIIVQDASPPAEPMKEFPEDVPAEKMDPEKTTKDEAPPEKTTVEEAL----PEKTTVD 747

  Fly   695 MFVPAAHSSNMHTSNTNSSNNHAHSDGPDSLNATYISVGGDKLTLSIPEQKPSTGSSSSSSTSST 759
            ..:|...:.:.................|:.:::........|:...:|.:.|....|||....|:
Zfish   748 EALPEKTTVDETPLEKTIEKTTVDETPPEKIHSEKTEDVPPKVPPKVPPKVPEKKHSSSYRFLSS 812

  Fly   760 ATTTTNGNGPYSNATFVSGFSAPLTPPSSLPANLNNTGSGCNTTLTSVTTISTPSSPTATVSTTA 824
            .:                  |||  ||||:.....:..:|      .::.....:||||.|...:
Zfish   813 MS------------------SAP--PPSSVRPRSEDLSAG------RISPALLRTSPTAKVPKPS 851

  Fly   825 SESVAPALS------------NASAAEILINEIFINNIINNNASGSITAETAA--KPAGSSTPSA 875
            .|.::|.|:            .|||:.            :.:||..:|...||  .|....:.|.
Zfish   852 FEEMSPELTALLQSARSWTPVPASASP------------SASASALVTPAPAALHTPQNQPSESV 904

  Fly   876 GTLLFSTLSEQERLESQKTNQQMNQSLNLNQNHSEVDAPPSEKKTPSNY---------PDSSRIP 931
            ...|...|:|:||...:..::            .:|.|||:....|..|         |.||...
Zfish   905 DEHLGKGLTEEERPADEPLDK------------PQVPAPPAGPLEPDGYYQACVACVEPLSSVRA 957

  Fly   932 FPSSSNSKDMVSPWLVSSEVVSAPKGR 958
            ...|.:..|......|:|..:..|..|
Zfish   958 LDESESDGDSSDSSSVNSTNLDGPLER 984

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yrt	NP_650291.1	B41	60..250	CDD:214604	85/189 (45%)
		FERM_N	62..124	CDD:286467	26/61 (43%)
		FERM_M	143..250	CDD:278785	50/106 (47%)
		FERM_C_NBL4_NBL5	246..339	CDD:270007	35/107 (33%)
		FA	352..392	CDD:285894	18/41 (44%)
		PHA03255	771..>924	CDD:165513	36/166 (22%)
epb41l3a	XP_021325820.1	B41	92..281	CDD:214604	85/189 (45%)
		FERM_C_4_1_family	276..384	CDD:270005	37/109 (34%)
		FA	393..434	CDD:312314	18/40 (45%)
		SAB	564..610	CDD:309500	11/75 (15%)
		DNA_pol3_delta2	<604..>780	CDD:331068	27/179 (15%)
		4_1_CTD	1064..1169	CDD:310467
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586175
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740