DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yrt and dnr1

DIOPT Version :9

Sequence 1:	NP_650291.1	Gene:	yrt / 41656	FlyBaseID:	FBgn0004049	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	NP_001261137.1	Gene:	dnr1 / 37575	FlyBaseID:	FBgn0260866	Length:	696	Species:	Drosophila melanogaster

Alignment Length:	917	Identity:	159/917 - (17%)
Similarity:	287/917 - (31%)	Gaps:	341/917 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 CRVILLDNTDLSIELSKKALGSFLYEQVFYALDII-EKDYFGLQFMDAN----HVKHWLDPTKPI 119
            |.|.|.:.|..:::...||.|....|:|..|::|| |.:||||:....|    ..:.|::    :
  Fly     3 CIVNLPNGTQQAVKWDPKANGQECLEKVCRAMNIICEMEYFGLEHWTPNQKESQTRQWIN----L 63

  Fly   120 KKQVK-------IGPPYTFRLKVKFYSSEPNTLREELTRYLFFLQLKQDLLEGRLDCPE-DKATE 176
            :.::.       .|......|:|||:......|:|.: |.||::|.::|||||||..|: ..|.:
  Fly    64 RNRLSGDSGSSGSGIQLMLALRVKFWVPVHFILQESV-RNLFYMQARRDLLEGRLTAPDWSGAAK 127

  Fly   177 LCALALQSELGDYDNQEHSAATVSEFRFVPEQTEDLEIAILDEYKTCRGLTPAQAETAFLNKAKW 241
            |.||..|::...::.....|......|                    |.|...|.:.
  Fly   128 LAALLCQADGLRFNESSLKADCPMRMR--------------------RELAQQQQQQ-------- 164

  Fly   242 LDMYGVDMHTVLGKDGCEYHLGLTPTGILVFERDQKIGLFFWPKISKLDFKKKKLTLIVIEDDDE 306
                         :...:.|                          :|:.::|
  Fly   165 -------------QQQAQQH--------------------------RLEQQRK------------ 178

  Fly   307 GREQEHTFVF---RLYNEKACKHLWKCAVEHHTFFRLRAPVKGPSARQNFFRMGSRFRYSGRTEF 368
              |:||...|   ||..:|:.:|:..|.:              |:|
  Fly   179 --EKEHVLSFKKRRLSKQKSMEHIEVCTL--------------PAA------------------- 208

  Fly   369 QTTQQSRARRTVQFERRPSQRFASRQSHLLRERQKASQEAAVSAVASVNARAAAAAAAAAASQSP 433
                     .|.....:||                    .:.||.||.:|.|:|:|:.:|.||:
  Fly   209 ---------STTSCSLQPS--------------------PSASASASASASASASASTSACSQT- 243

  Fly   434 APATPLVSSQVSTPTPNNDNNNDAFDSLISTDQFITVTPSPSVLTVIQNSAIIEPDAACSGSISS 498
                   .|..|:.:|:|.::....|..::::..           .:.....::|  :|.|...:
  Fly   244 -------HSNSSSSSPSNSSSQTGLDERLASNPL-----------RVYEEYFMQP--SCEGEPPA 288

  Fly   499 S--SQAAANFASLGRNSLKSNFSNEDPAYSKIGSIGKASGLTVKLDPDYTPPYSPNATKNFDETN 561
            .  .|.|.....|.    |...|.:...|..:.||....|...:|
  Fly   289 DYLRQIAVEHGKLA----KLQMSLKTAKYWLLKSIQDLEGYGEEL-------------------- 329

  Fly   562 PFRNATSSHHGSFGKASISSGQLSVKSGLSDKDRELDSLLKSIVKDPSPSVLANEAINDANSIRV 626
             |...|::...:....::.:..::|..|     .|..|:       |..::.|      |.|:|.
  Fly   330 -FSGVTTNESATRCDIAVGAHGITVCRG-----GEKQSI-------PFGAIAA------AKSLRR 375

  Fly   627 TINKTFDMDHNTETLKRLSNANEKPNNQVKLANVNTTALPPGNIKCNILKARVEEEL-------- 683
            |....:..||           |::...::|        ||...|...:.::..|...
  Fly   376 TFKLEYVDDH-----------NDRKELEIK--------LPKQPIAAGLYRSITERHAFYVCDKVR 421

  Fly   684 GAGGNAKLTNQ-----------MFVPAAHSSNMHTSNTNSSNNHAHSDGPDSLNATYISVGGDKL 737
            |.     :|||           ||:........:..:...:....|    |....|....|||.:
  Fly   422 GV-----VTNQFTRDLKGTIASMFMENTELGKRYVFDIQHTCREVH----DQARRTLHERGGDLV 477

  Fly   738 TLSIPEQKPSTGSSSSSSTSSTATTTTNGNGPYSNATFVSGFSAPLTPPSSLPANLNNTGSGCNT 802
            .      :.:.|.|:.:.....:.....|..|::.|         ||           ||:|.:.
  Fly   478 A------EGAEGCSAVAGGLGASAVGEPGVSPWAMA---------LT-----------TGAGGSM 516

  Fly   803 TLTSVTTISTPSSPTATVSTTASESVAPALSNASAAEILINEIF--INNII---------NN--N 854
            .......|....:..|.:.......::.|:......:..||.:|  ..::|         :|  |
  Fly   517 AGKIDLAIREKEAREAAIERCVDTRISEAMQCKICMDRAINTVFNPCCHVIACAQCAARCSNCPN 581

  Fly   855 ASGSITA----------ETAAKPAGSSTPSAGTLLFSTLSEQERLESQKTNQQMNQSLNLNQNHS 909
            ....||:          .|:...:|::|.|:     |::....::|.|...||::
  Fly   582 CRVKITSVVKIYLPPELRTSQTGSGATTTSS-----SSIMGDGQVEEQLLQQQLD---------- 631

  Fly   910 EVDAPPS 916
            |:.|.|:
  Fly   632 EISAAPA 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yrt	NP_650291.1	B41	60..250	CDD:214604	48/202 (24%)
		FERM_N	62..124	CDD:286467	18/66 (27%)
		FERM_M	143..250	CDD:278785	24/107 (22%)
		FERM_C_NBL4_NBL5	246..339	CDD:270007	12/95 (13%)
		FA	352..392	CDD:285894	3/39 (8%)
		PHA03255	771..>924	CDD:165513	29/169 (17%)
dnr1	NP_001261137.1	B41	3..>143	CDD:214604	43/144 (30%)
		FERM_N	5..67	CDD:286467	18/65 (28%)
		FERM_M	93..>143	CDD:278785	19/50 (38%)
		FERM_C_MYLIP_IDOL	325..435	CDD:270016	25/172 (15%)
		zf-C3HC4_3	544..589	CDD:290631	9/44 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455763
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23280
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940