DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yrt and epb41l5

DIOPT Version :9

Sequence 1:	NP_650291.1	Gene:	yrt / 41656	FlyBaseID:	FBgn0004049	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	NP_956383.1	Gene:	epb41l5 / 368449	ZFINID:	ZDB-GENE-030616-450	Length:	772	Species:	Danio rerio

Alignment Length:	1014	Identity:	356/1014 - (35%)
Similarity:	476/1014 - (46%)	Gaps:	292/1014 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RFLSRRKVRNNYVDNS--REGGGATSSAVGVAGGGGAITSGGSSQIKPQRIVVNKNKIDCRVILL 65
            |.|.||.:| .:.:.:  ||...||:.          |.:.|.:          |:.|.|||.||
Zfish     7 RTLGRRSIR-KHAEKARLREAQRATTH----------IPAAGDA----------KSIITCRVSLL 50

  Fly    66 DNTDLSIELSKKALGSFLYEQVFYALDIIEKDYFGLQFMDANHVKHWLDPTKPIKKQVKIGPPYT 130
            |.||:|::|.|||.|:.|:||:.|.||::|||||||:|||:..|.||||.||.|||||||||||.
Zfish    51 DGTDVSVDLPKKAKGAELFEQIMYHLDVVEKDYFGLRFMDSAQVPHWLDVTKSIKKQVKIGPPYC 115

  Fly   131 FRLKVKFYSSEPNTLREELTRYLFFLQLKQDLLEGRLDCPEDKATELCALALQSELGDYDNQEHS 195
            ..::|||||||||.|.||||||||.||||||:|.|:|:||.|...||.:.|||:||||||..||.
Zfish   116 LHMRVKFYSSEPNNLHEELTRYLFVLQLKQDILSGKLECPFDTTVELASYALQAELGDYDPAEHG 180

  Fly   196 AATVSEFRFVPEQTEDLEIAILDEYKTCRGLTPAQAETAFLNKAKWLDMYGVDMHTVLGKDGCEY 260
            ...||||||:|.||||:|:||.:.:|.|||.||||||..:|||||||:|||||||.|..:||.||
Zfish   181 LDLVSEFRFIPNQTEDMEVAIYNAWKECRGQTPAQAEINYLNKAKWLEMYGVDMHMVKARDGNEY 245

  Fly   261 HLGLTPTGILVFERDQKIGLFFWPKISKLDFKKKKLTLIVIEDD-------DEGREQEHTFVFRL 318
            .|||||||:||||.:.||||||||||::|||||.||||:|:|||       :||:|||||||||:
Zfish   246 SLGLTPTGVLVFEGETKIGLFFWPKITRLDFKKCKLTLVVVEDDEQVMQETEEGKEQEHTFVFRM 310

  Fly   319 YNEKACKHLWKCAVEHHTFFRLRAPVKGPSARQNFFRMGSRFRYSGRTEFQTTQQSRARRTVQFE 383
            .:.||||||||||||||.|||||.||:..|||..|.||||||||||:||:|||:.::|||:..||
Zfish   311 DHPKACKHLWKCAVEHHAFFRLRGPVQKSSARSGFIRMGSRFRYSGKTEYQTTKANKARRSASFE 375

  Fly   384 RRPSQRFASRQSHLLRERQKASQEAAVSAVASVNARAAAAAAAAAASQSPAPATPLVSSQVSTPT 448
            ||||:|: ||::.|.|...|:|.........|:..:       ...::.|....|:|||..|.|.
Zfish   376 RRPSRRY-SRRTMLNRGPNKSSDNHNNGVSPSIEKK-------PTHTRPPWSGMPVVSSPPSAPG 432

  Fly   449 PNNDNNNDAFDSLISTDQFITVTPSPSVLTVIQNSAIIEPDAACSGSISSSSQAAANFASLGRNS 513
            |.               :..|:..||                       ..||:......:..:.
Zfish   433 PM---------------EIETLPRSP-----------------------GGSQSDKRSMPIVTDL 459

  Fly   514 LKSNFSNEDPAYSKIGSIGKASGLTVKLDPDYTPPYSPNATKNFDETNPFRNATSSHHGSFGKAS 578
            |::             .:.:....||           |.||  .:|..|....||:       :|
Zfish   460 LET-------------CVDEVLQATV-----------PMAT--VEEAGPGAAHTSA-------SS 491

  Fly   579 ISSGQLSVKSGLSDKDRELDSLLKSIVKDPSP-SVLANEAINDANSIRVTINKTFDMDHNTETLK 642
            ::...||:        .|..:.||.:..:.:| ||.|...:|      :.:|...|:...||  |
Zfish   492 VTEETLSL--------TEAAARLKQLEIENTPVSVPARTNVN------LNMNNQDDVVKLTE--K 540

  Fly   643 RLSNANEKP-NNQVKLANVNTTALPPGNIKCNILKARVE-------EELGAGGNAKLTNQMFVPA 699
            .|::.:..| .||:|         .|..:|.|||||:.|       :|||.
Zfish   541 SLNSVSSSPVLNQLK---------APDELKSNILKAQAEAALKDSRDELGL-------------- 582

  Fly   700 AHSSNMHTSNTNSSNNHAHSDGPDSLNATYISVGGDKL--TLSIPE-------------QKPSTG 749
                   |.:.|.:...|         |..::..|.::  |.|:|.             ::|...
Zfish   583 -------TPDKNCNLQEA---------AARLTGRGGRMGSTTSLPVSGRAERQESWDMLKQPGLL 631

  Fly   750 SSSSSSTSSTATTTTNGNGPYSNATFVSGFSA--------PLTPPSSLPANLNNTGSGCNTTLTS 806
            .||:||....|....:...|.|:.......|:        |||.|  |..||        ...|.
Zfish   632 PSSTSSLEEKADDFISSVPPLSSDPVNEAHSSKVKVEDPEPLTAP--LTDNL--------IDFTD 686

  Fly   807 VTTISTPSSPTATVSTTASESVAPALSNASAAEILINEIFINNIINNNASGSITAETAAKPAGSS 871
            ...:..|..||.|     ...:.|                                 |:.|..|.
Zfish   687 PLPVVPPPKPTIT-----PRWIIP---------------------------------ASAPTQSG 713

  Fly   872 TPSAGTLLFSTLSEQERLESQKTNQQMNQSLNLNQNHSEVDAPPSEKKTPSNYPDSSRIPFPSSS 936
            |.:.|.|                                 |.|   .|..|::|:.|..|.|..|
Zfish   714 TFTNGLL---------------------------------DCP---TKVSSHHPEGSVSPLPQLS 742

  Fly   937 NSKDMVSPWLVSSEVVS---APKGRESAIIRKSVITTQL 972
            .:.::::..:|:.....   .|||         ::||:|
Zfish   743 QTHNVIATSIVAHSTKDNNHKPKG---------LLTTEL 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yrt	NP_650291.1	B41	60..250	CDD:214604	127/189 (67%)
		FERM_N	62..124	CDD:286467	39/61 (64%)
		FERM_M	143..250	CDD:278785	71/106 (67%)
		FERM_C_NBL4_NBL5	246..339	CDD:270007	70/99 (71%)
		FA	352..392	CDD:285894	26/39 (67%)
		PHA03255	771..>924	CDD:165513	25/160 (16%)
epb41l5	NP_956383.1	B41	44..235	CDD:214604	127/190 (67%)
		FERM_N	47..109	CDD:286467	39/61 (64%)
		FERM_B-lobe	135..227	CDD:271216	59/91 (65%)
		FERM_C_NBL4_NBL5	231..331	CDD:270007	70/99 (71%)
		FA	344..>375	CDD:285894	19/30 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586173
Domainoid	1	1.000	159	1.000	Domainoid score	I4057
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D129183at33208
OrthoFinder	1	1.000	-	-		FOG0003429
OrthoInspector	1	1.000	-	-		oto39048
orthoMCL	1	0.900	-	-		OOG6_108300
Panther	1	1.100	-	-	LDO	PTHR23280
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2790
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	11	11.350