DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yrt and CG5022

DIOPT Version :9

Sequence 1:	NP_650291.1	Gene:	yrt / 41656	FlyBaseID:	FBgn0004049	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	NP_609384.1	Gene:	CG5022 / 34398	FlyBaseID:	FBgn0032225	Length:	572	Species:	Drosophila melanogaster

Alignment Length:	648	Identity:	178/648 - (27%)
Similarity:	259/648 - (39%)	Gaps:	172/648 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 CRVILLDNTD-LSIELSKKALGSFLYEQVFYALDIIEKDYFGLQFMDANHVKHWLDPTKPIKKQV 123
            |.|.|||::| |..|......|.:|.|.:...|:|.|||||||:::|::..:||||.:|.|.||.
  Fly    14 CTVRLLDDSDVLECEFQPFHKGIYLLEYLCGELEIKEKDYFGLRYVDSSKQRHWLDLSKSIIKQC 78

  Fly   124 KIGPPYTFRLKVKFYSSEPNTLREELTRYLFFLQLKQDLLEGRLDCPEDKATELCALALQSELGD 188
            |...|..|.|:||||.::|..|... .|.:.:.|||:||..|||.|...:|..|.||.:|.||||
  Fly    79 KEMDPLLFSLRVKFYPADPFRLTGN-ARIMLYQQLKRDLRHGRLYCSLGEAAALGALIVQEELGD 142

  Fly   189 YDNQEHSAATVSEFRFVPEQTEDLEIAILDEYKTCR-GLTPAQAETAFLNKAKWLDMYGVDMHTV 252
            |:...|..:.||.......|||.||..|::.:|... |...:.|...||..|:.|:.||:|.|.|
  Fly   143 YNEDVHVGSYVSSIELALRQTECLEKKIIELHKKREPGQNLSLAMDEFLGIARGLETYGIDPHPV 207

  Fly   253 LGKDGCEYHLGLTPTGILVFERDQKIGLFFWPKISKLDFKKKKLTLIVIEDDDEGREQEHTFVFR 317
            ....|.:.::|:..|||..|...::...|.|.:|.|::|:.|.....:...|.....::||..|:
  Fly   208 KDHRGSQQYVGINNTGISTFVAGKRSQHFRWNEIHKINFEGKMFIAHLSYTDASREPKKHTVGFK 272

  Fly   318 LYNEKACKHLWKCAVEHHTFFRL-----RAPVKGPSARQNFFRMGSRFRYSGRTEFQTTQQSRAR 377
            .....||::||:||:|...||.|     .|.:.|    ..||..|::|||:||||
  Fly   273 CPTGAACRYLWRCAIEQMLFFTLPNSQSAAVISG----GGFFSWGTKFRYTGRTE---------- 323

  Fly   378 RTVQFERRPSQRFASRQSHLLRERQKASQEAAVSAVASVNARAAAAAAAAAASQSPAPATPLVSS 442
                      :...:...:.|||::..|..:...|                   |..||||
  Fly   324 ----------REILTENINALREQKNNSNSSKRKA-------------------SSVPATP---- 355

  Fly   443 QVSTPTPNNDNNNDAFDSLISTDQFITVTPSPSVLTVIQNSAIIEP------------------D 489
                .:|..|.....:.||                   ..|.:.||                  |
  Fly   356 ----SSPQGDLAQIRYSSL-------------------PRSTMSEPLGYGMPNGHFYGHDHGMSD 397

  Fly   490 AACSGSIS-SSSQAAANFASLGRNSLKSNFSNEDPAYSKIGSI---------GKASGLTVKLDPD 544
            |  :|.|. ||.:.....|.|    ..||....:...|:||..         ...|||||
  Fly   398 A--NGGIQISSLEPVCEEARL----RSSNIDGVNYLASQIGGYAYRDSVEHSSTESGLTV----- 451

  Fly   545 YTPPYSPNATKNFDETNPFRNATSSHHGSFGKASISSGQLSVKSGLSDKDRELDSLLKSIVKDPS 609
                      ..:|  :|.::..:..|||: ..::..||   ..|..:.....||.|.:   |||
  Fly   452 ----------NGYD--HPRKHNEARQHGSY-SPNLYYGQ---SDGAVNSSSPADSFLHA---DPS 497

  Fly   610 -----------------PSV------LANEAINDANSIRVTINKTFDMDHNTETLKRLSNANE 649
                             |||      :|..|:             |.|:..:|..::|.|:.|
  Fly   498 TRKVKKFRKFHLLHAFVPSVIFVAFAMAGTAV-------------FIMESESEAFEQLRNSPE 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yrt	NP_650291.1	B41	60..250	CDD:214604	78/191 (41%)
		FERM_N	62..124	CDD:286467	28/62 (45%)
		FERM_M	143..250	CDD:278785	40/107 (37%)
		FERM_C_NBL4_NBL5	246..339	CDD:270007	28/92 (30%)
		FA	352..392	CDD:285894	10/39 (26%)
		PHA03255	771..>924	CDD:165513
CG5022	NP_609384.1	B41	13..205	CDD:214604	78/191 (41%)
		FERM_N	16..80	CDD:286467	28/63 (44%)
		FERM_M	108..205	CDD:278785	38/96 (40%)
		FERM_C_FRMD3_FRMD5	186..294	CDD:270013	34/107 (32%)
		FA	308..349	CDD:285894	15/79 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455760
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3530
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D39990at50557
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23280
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850