DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yrt and Frmd5

DIOPT Version :9

Sequence 1:	NP_650291.1	Gene:	yrt / 41656	FlyBaseID:	FBgn0004049	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	XP_038962754.1	Gene:	Frmd5 / 311362	RGDID:	1561554	Length:	599	Species:	Rattus norvegicus

Alignment Length:	545	Identity:	160/545 - (29%)
Similarity:	258/545 - (47%)	Gaps:	99/545 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 ITSGGSSQIKPQRIVVNKNKIDCRVILLDNTDLSIELSKKALGSFLYEQVFYALDIIEKDYFGLQ 102
            :.||.|..:        :.:..|.|.|||:::.:..:.:.|.|.:|::.:.:.|:::||||||::
  Rat     5 LMSGSSRSL--------EREYSCTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIR 61

  Fly   103 FMDANHVKHWLDPTKPIKKQVKIGPPYTFRLKVKFYSSEPNTLREELTRYLFFLQLKQDLLEGRL 167
            |:|.:..:|||:.||.:.||::..||:|...:||||.::|..|:||:||||.|||:|:||..|||
  Rat    62 FVDPDKQRHWLEFTKSVVKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRL 126

  Fly   168 DCPEDKATELCALALQSELGDYDNQEHSAATVSEFRFVPEQTEDLEIAILDEYKT-CRGLTPAQA 231
            .|....|..|.|..||:|:||||..:|.....|:|:|.|:.:|.||..|.:.:|| ..|.|||.:
  Rat   127 LCKTSDAALLAAYILQAEIGDYDPGKHPEGYSSKFQFFPKHSEKLEKKIAEIHKTELSGQTPATS 191

  Fly   232 ETAFLNKAKWLDMYGVDMHTVLGKDGCEYHLGLTPTGILVFERDQKI------------------ 278
            |..||.||:.|:.||||.|......|....|..||.|.:|.:.::::
  Rat   192 ELNFLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKCILFASFTAAIHWA 256

  Fly   279 GLF-----------FWPKISKLDFKKKKLTLIVIEDDDEGREQEHTFVFRLYNEKACKHLWKCAV 332
            |.|           .|.:::||.|:.|...|.|.:.:    |::....:.....:||||||||.:
  Rat   257 GGFKDFSTITPKPLSWNEVTKLKFEGKTFYLYVSQKE----EKKIILTYFAPTPEACKHLWKCGI 317

  Fly   333 EHHTFFRLR--APVKGPSARQNFFRMGSRFRYSGRTEFQTTQQSR--ARRTVQFERR-------- 385
            |:..|::|.  :.|:..|:...||: |||||||||...:..:.|.  .|...:..|.
  Rat   318 ENQAFYKLEKSSQVRTVSSSNLFFK-GSRFRYSGRVAKEVMESSAKIKREPPEIHRAGMVPSRSC 381

  Fly   386 PSQRFASRQSHLLRERQKASQEAAVSAVASV--------------------NARAAAA----AAA 426
            ||.....|.|.:.|.|::|...:.:..:.|:                    :.|::.|    ..|
  Rat   382 PSITHGPRLSSVPRTRRRAVHISIMEGLESLRDSAHSTPVRSSSHGDTFLPHVRSSRADSNERVA 446

  Fly   427 AAASQSPAPATPLVSSQVSTPTPNNDNN----------NDAFDSLISTDQFITVTPSPSVLTVIQ 481
            ..|.::.:||..::      |||..:::          |.|..|:....:..|.||:.:....:.
  Rat   447 VIADEAYSPADSVL------PTPVAEHSLELMLLSRQINGATCSIEEEKESETSTPTSTEAEALG 505

  Fly   482 NSAIIEPDAACSGSISSSSQAAANF 506
            .    |..|.|.|...|..:....|
  Rat   506 G----ELRALCQGHGGSEQEQVNKF 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yrt	NP_650291.1	B41	60..250	CDD:214604	84/190 (44%)
		FERM_N	62..124	CDD:286467	23/61 (38%)
		FERM_M	143..250	CDD:278785	52/107 (49%)
		FERM_C_NBL4_NBL5	246..339	CDD:270007	30/121 (25%)
		FA	352..392	CDD:285894	16/49 (33%)
		PHA03255	771..>924	CDD:165513
Frmd5	XP_038962754.1	B41	19..210	CDD:214604	84/190 (44%)
		PH-like	191..324	CDD:418428	37/136 (27%)
		FA	338..383	CDD:400882	14/45 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345145
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740