DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yrt and Epb41l2

DIOPT Version :9

Sequence 1:	NP_650291.1	Gene:	yrt / 41656	FlyBaseID:	FBgn0004049	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	XP_017445330.1	Gene:	Epb41l2 / 309557	RGDID:	1563977	Length:	1101	Species:	Rattus norvegicus

Alignment Length:	884	Identity:	235/884 - (26%)
Similarity:	372/884 - (42%)	Gaps:	152/884 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 EGGGATSSAVGVAGGGGAITSGGSSQIKPQRIVVNKNKIDCRVILLDNTDLSIELSKKALGSFLY 84
            |||.|......|.      ||...:::..|:.......:..:|.|||.|:.|.:|.|:|.|..|:
  Rat   181 EGGAAKRETKEVQ------TSELKAEVASQKAAKKTKTVLAKVTLLDGTEFSCDLEKRAKGQALF 239

  Fly    85 EQVFYALDIIEKDYFGLQFMDANHVKHWLDPTKPIKKQVKIGPPYTFRLKVKFYSSEPNTLREEL 149
            ::|...|:::|||||||.|.:....|:||||.|.||:|:: ..|:.|...||||..:|:.|.|::
  Rat   240 DRVCEHLNLLEKDYFGLIFQEHPEQKNWLDPAKEIKRQLR-SLPWLFTFNVKFYPPDPSQLTEDI 303

  Fly   150 TRYLFFLQLKQDLLEGRLDCPEDKATELCALALQSELGDYDNQEHSAATVSEFRFVPEQTEDLEI 214
            |||...|||:||:..|||.|.......|.:..||:|.||||.:|:.:..:.:|:|.|...::||.
  Rat   304 TRYFLCLQLRQDISSGRLPCSFVTHALLGSYTLQAEHGDYDPEEYDSIDLGDFQFAPTHNKELEE 368

  Fly   215 AILDEYKTCRGLTPAQAETAFLNKAKWLDMYGVDMHTVLGKDGCEYHLGLTPTGILVFERDQKIG 279
            .:.:.:||.|||:||||::.||..||.|.|||||:|.....:|.:..||:...|:|:::...:|.
  Rat   369 KVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRIN 433

  Fly   280 LFFWPKISKLDFKKKKLTLIVIEDDDEGREQEHTFVFRLYNEKACKHLWKCAVEHHTFFRLRAPV 344
            .|.||||.|:.:|:....:.|...:.|  :.|.|..|:|.|.:|.|.|||..||||||:||.:|.
  Rat   434 RFAWPKILKISYKRSNFYIKVRPGELE--QFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPE 496

  Fly   345 KGPSARQNFFRMGSRFRYSGRTEFQTTQQSRA--RRTVQFERRPSQRFASR----------QSHL 397
            :.|..:  |..:||:|||||||:.||.:.|..  |...||||..|:| .||          ...|
  Rat   497 QPPKTK--FLTLGSKFRYSGRTQAQTREASTLIDRPAPQFERASSKR-VSRSLDGAPIGVVDQSL 558

  Fly   398 LRERQKASQEAAVSAVASVNARAAAAAAAAAASQSPAPATPLVS-SQVSTPTPNNDNNNDAFDSL 461
            :::......|.:|.....|:  ...........:||...|||:: .:.:|...:.||......:|
  Rat   559 MKDFPGPPGEGSVPGPGVVS--YTTVQDGRRDGKSPTKVTPLLAEGKKNTLRVDGDNIYVRHSNL 621

  Fly   462 ISTD--------------------QFITVTPSP-------------SVLTVIQNSAIIEPDAACS 493
            :..|                    .|:..||.|             |...:.:||..:..|...:
  Rat   622 MLEDLDKAQEAILKHQASVSELKRNFMESTPEPRPSEWEKRRVTPLSCQILARNSQTLFKDILSA 686

  Fly   494 GSISSSSQAAANFASLGRNSLKSN-----FSNEDPAYSKIGSIGKAS-----GLTVKLDPDYTP- 547
            ..:  |..|||........||:..     ||.:..::|...|...|:     |..|..:....|
  Rat   687 KLM--SQMAAARTPEEATQSLEEEITSILFSGQGFSHSVKASFPSATTWTAEGTVVNANAPREPL 749

  Fly   548 --------PYSPNATKNFDETNPFRNATSSHHGSFG------KASISSGQLSVKSGLSDKD---- 594
                    |.:|.|..:.......|:|..|.|.:..      :|.:..|:..:...::.|:
  Rat   750 SSAPFSRLPETPRALVSEGPCTGTRDAVKSSHETLNVVEEKKRAEVGKGESVITEEMNGKELSPG 814

  Fly   595 ------RELDSLL----KSIVKDPSPSVLANEAINDANSI----RVTINKTFDMDHNTETLKRLS 645
                  |:::.:.    .|:..:.|.|  ::|:..|....    |||.....:.....|.|:
  Rat   815 SGPGETRKVEPMAHKDSTSLSSESSSS--SSESEEDVGEYQPHHRVTEGTIREEQEYEEELE--- 874

  Fly   646 NANEKPNNQVKLANVNTT---ALPPGNIKCNILKARVEEE--------LGAGGNAKLTNQMFVPA 699
               |:|....|:......   |:|......::|....|.:        .|..|..:.|.:..:..
  Rat   875 ---EEPGQGAKVVEREAAMPEAIPDRQAGASVLPVETEAQENVVAQKLPGEKGAHRGTAEQDMSE 936

  Fly   700 AHSSNMHTSNTNSSNNHAHSDG--------------------PDSLNATYIS------VGGDKLT 738
            ....:.|  ..|....|...||                    .|:...|.||      |..:..|
  Rat   937 EAEEDQH--RVNGEVPHLDIDGLPEIVCPSEPPVVKTEMVTISDASQRTEISTKEVPIVQTETKT 999

  Fly   739 LSIPEQKPSTGSSSSSSTSSTATTTTNGNGPYSNATFVS 777
            ::....:...|:...|....||.|.|:.:...:..|.::
  Rat  1000 ITYESPQIDGGAGGDSGVLLTAQTITSESASTTTTTHIT 1038

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yrt	NP_650291.1	B41	60..250	CDD:214604	84/189 (44%)
		FERM_N	62..124	CDD:286467	30/61 (49%)
		FERM_M	143..250	CDD:278785	47/106 (44%)
		FERM_C_NBL4_NBL5	246..339	CDD:270007	35/92 (38%)
		FA	352..392	CDD:285894	20/41 (49%)
		PHA03255	771..>924	CDD:165513	1/7 (14%)
Epb41l2	XP_017445330.1	PTZ00121	<4..>216	CDD:173412	8/40 (20%)
		B41	215..404	CDD:214604	84/189 (44%)
		FERM_C_4_1_family	399..492	CDD:270005	36/94 (38%)
		FA	502..545	CDD:400882	21/45 (47%)
		SAB	622..662	CDD:398195	5/39 (13%)
		4_1_CTD	989..1094	CDD:399118	9/50 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345147
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840